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Journals / Journal of Basic and Clinical Health Sciences / 2021 / Cilt: 5 - Sayı: 1

ORGANOID AS A NOVEL TECHNOLOGY FOR DISEASE MODELING

Tolga SEVER
Ilgın ÇEVİK
Ender Berat ELLİDOKUZ
Gizem ÇALIBAŞI KOCAL
Yasemin BAŞBİNAR
Pages
94–101
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thereview describes the recent development of organoid disease modeling approaches.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The organoid technology is capable to create more real-like in vitro models in terms of structure andfunction of the origin of the tissue.
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Key Findings & Data:Since the three-dimensional model is able to illustrate diseasepathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promisingdisease model to fill the gap between conventional two-dimensional, and in vivo disease models.
💡
Conclusion & Impact:Thereview describes the recent development of organoid disease modeling approaches.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The organoid technology is capable to create more real-like in vitro models in terms of structure andfunction of the origin of the tissue. Since the three-dimensional model is able to illustrate diseasepathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promisingdisease model to fill the gap between conventional two-dimensional, and in vivo disease models. Thereview describes the recent development of organoid disease modeling approaches.

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Cite This Article

SEVER, T., ÇEVİK, I., ELLİDOKUZ, E. B., KOCAL, G. Ç., BAŞBİNAR, Y. (2022). ORGANOID AS A NOVEL TECHNOLOGY FOR DISEASE MODELING. Journal of Basic and Clinical Health Sciences, Cilt: 5 - Sayı: 1, 94–101. https://ajindex.com/articles/560514

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References (16)

  1. Duval K, Grover H, Han LH, et al. Modeling physiological events in 2d vs. 3d cell culture. Physiology (bethesda) 2017; 32(4):266-277
  2. Byrne AT, Alférez DG, Amant F, et al. Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nat Rev Cancer 2017; 17(4):254-268
  3. Haycock JW. 3D cell culture: a review of current approaches and techniques. Methods Mol Biol 2011; 695:1-15
  4. Mahe MM, Aihara E, Schumacher MA, et al. Establishment of gastrointestinal epithelial organoids. Curr Protoc Mouse Biol 2013; 3(4):217- 240
  5. Takebe T, Zhang RR, Koike H, et al. Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nat Protoc 2014; 9(2):396-409
  6. Schreurs RRCE, Baumdick ME, Sagebiel AF, et al. Human fetal tnf-α-cytokine-producing cd4+ effector memory T cells promote intestinal development and mediate inflammation early in life. Immunity 2019; 50(2):462-476
  7. Noel G, Baetz NW, Staab JF, et al. A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and hostpathogen interactions. Sci Rep 2017; 7:45270
  8. Koike H, Iwasawa K, Ouchi R, et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature 2019; 574(7776):112-116
  9. Fujii M, Matano M, Nanki K, Sato T. Efficient genetic engineering of human intestinal organoids using electroporation. Nat Protoc 2015; 10(10):1474-1485
  10. Dutta D, Heo I, Clevers H. Disease modeling in stem cell-derived 3d organoid systems. Trends Mol Med 2017; 23(5):393-410
  11. Liu B, Song Y, Liu D. Recent development in clinical applications of PD-1 and PD-L1 antibodies for cancer immunotherapy. J Hematol Oncol 2017; 10(174)
  12. Pang Y, Hou X, Yang C, Liu Y, Jiang G. Advances on chimeric antigen receptor-modified t-cell therapy for oncotherapy. Mol Cancer 2018; 17(1):91
  13. Zhou J, Su J, Fu X, Zheng L, Yin Z. Microfluidic device for primary tumor spheroid isolation. Exp Hematol Oncol 2017; 6:22
  14. Ben-David U, Ha G, Tseng YY, et al. Patientderived xenografts undergo mouse-specific tumor evolution. Nat Genet 2017; 49(11):1567- 1575
  15. Na JC, Kim JH, Kim SY, et al. Establishment of patient-derived three-dimensional organoid culture in renal cell carcinoma. Investig Clin Urol 2020; 61(2):216-223. 16. van de Wetering M, Francies HE, Francis JM, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 2015; 161(4):933-945
  16. Weeber F, van de W