Journals / Journal of Applied Biological Sciences / 2008 / Cilt: 2 - Sayı: 3

Histopathological effects of malathion and endosulfan on blood cells of wistar albino rats (Rattus norvegicus)

Pages
105–108
Publication Date
2022-10-18
DOI
—
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In conclusion, we have observed deformations in nucleus and cytoplasms of blood cells caused by different doses of malathion and endosulfan.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study is an investigation of histopathological effects of malathion and endosulfan such as widely used insecticides in Turkey, on blood cells of wistar albino rats.
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Key Findings & Data:In this study, we have used 20 wistar albino rats.
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Conclusion & Impact:In conclusion, we have observed deformations in nucleus and cytoplasms of blood cells caused by different doses of malathion and endosulfan.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study is an investigation of histopathological effects of malathion and endosulfan such as widely used insecticides in Turkey, on blood cells of wistar albino rats. In this study, we have used 20 wistar albino rats. These studies showed that erythrocyte cells have structural defects, degenerative cell size and surface shapes and also discomformity on membrane surfaces in rats administered endosulfan and malathion. It was also observed that these histopathological defects are related to dose increments. It has been demonstrated that the disconformity of leukocyte membranes is more pronounced when compared to erytrocyte membranes. It was also observed that the blood cells (leukocytes and erythrocytes) of rats in control group have a normal histological appearance. In conclusion, we have observed deformations in nucleus and cytoplasms of blood cells caused by different doses of malathion and endosulfan.

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Cite This Article

KAYHAN, F. E., SESAL, C., KOÇ, N. D., MUŞLU, M. N. (2022). Histopathological effects of malathion and endosulfan on blood cells of wistar albino rats (Rattus norvegicus). Journal of Applied Biological Sciences, Cilt: 2 - Sayı: 3, 105–108. https://ajindex.com/articles/560280

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References (1)

  1. . Kurutaş EB, Doran F. 2001. The effect of endosulfan on hematologic parameters in Mus musculus. T Klin J Med Sci. 21:150-154. [2]. Yavaşoğlu A, Sayım F, Uyanıkgil Y, Turgut M, Karabay- Yavaşoğlu NÜ. 2006. The pyrethroid cypermethrininduced biochemical and histological alterations in rat liver. Journal of Health Science. 52(6):774-780. [3]. Tos-Luty S, Obuchow-Przebirowska D, Latuszynska J, Tokarsa-Rodak M, Haratym-Maj A. 2003. Dermal and oral toxicity of malathion in rats. Ann Agric Environ Med. 10:101-106. [4]. Timur S, Önal S, Karabay NÜ, Sayım F, Zihnioğlu F. 2003. In vivo effects of malathion of glutathione-S transferase and acetylcholinesterase activities in various tissues of neonatal rats. Turk J Zool. 27:247-252. [5]. Berkarda B, Eyupoglu H. 1983. Giemsa boyama tekniği hematoloji laboratuar yöntemleri. İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi. 78-80 [6]. Çömelekoğlu Ü, Mazmancı B, Arpacı A. 2000. Investigation of the liver functions in agricultural workers chronically exposed to pesticides. (in Turkish) Turk J Biol. 24:461-466. [7]. Nikinmaa M. 1992. How does environmental pollution effect red cell function in fi sh? Aquatic Toxicology. 22: 227-238. [8]. Gill ST, Pant CJ. 1985. Mercury-induced blood anomalities in the freshwater teleost Barbus conchoniuc Hamsters. Water, Air and Soil Poll. 24:165-171. [9]. Konuk T. 1981. Pratik Fizyoloji. Ankara Üniversitesi, Veteriner Fakültesi Yayınları. Sayfa: 378. [11]. Güney M, Demirin H, Oral B, Take G, Giray SG, Delibaş N, Mungan T. 2007. Protective effects of vitamins E and C against dichlorvos-induced fallopian damage in rats. Türk Jinekoloji ve Obstetrik Derneği Dergisi. 4(4):259- 266. [12]. Gupta M, Bagchi G, Bandyopadhyay S, Samsla D, Chatterjee T, Dey SN. 1982. Heamatological changes produced in mice by nuvacron and furadan toxicology. 25(2-3):255-260. [13]. Hazarika A, Saklar SN, Hajare S, Kataria M, Malik M.K. 2003. Infl uence of malathion pretreatment on the toxicity of anilofos in male rats: A biochemical interaction study. Toxicology. 185:1-8. [14]. Gultekin F, Delibas N, Yasar S, Kilinc I. 2001. In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin E on oxidative damage in erythrocytes induced by chlorpyrifos-ethyl in rats. Arch Toxicol. 75:88-96. [15]. Farrag ARH, Shalby SM. 2007. Comparative haematological and hepatorenal toxicity of IGR, lufenuron and profenos insecticide on albino rats. Journal of Applied Sciences Research. 3(5):377-38