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Journals / Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi / 2012 / Cilt: 9 - Sayı: 34

Polikistik over hastalarında insulin direnci, metabolik durum ve metabolik parametreler arasındaki ilişki

Insulin resistance, metabolic status and relation between metabolic parameters in polycystic ovary syndrome patients

Gülnur ÖZAKŞİT
Elif Gül EYİ YAPAR
Yunus YILDIZ
Hasan ENERGİN
Emre ÖZGÜ
Bekir Serdar ÜNLÜ
Pages
1413–1420
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results : On Body Mass Index (BMI) match tests; serum levels of fasting glucose, fasting insulin and 2. hour 75 gr OGTT results were significantly higher in patients with BMI>25 (n=32 %39,5) (p25 (n=49 %60,5) serum levels of triglyseride were significantly higher than patients with BMI

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: to investigate the hormonal status, insulin resistance, clinical and metabolic parameters and their correlation in polycystic ovary syndrome (PCOS) patients.
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Key Findings & Data:Material And Methods: The study was performed on a total of 81 patients with menstrual irregularity, hirsutism and obesity who were admitted to Zekai Tahir Burak Women s Health Educational and Research Hospital infertility and adolescent outpatient clinics between August 2010- August 2011.
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Conclusion & Impact:Results : On Body Mass Index (BMI) match tests; serum levels of fasting glucose, fasting insulin and 2. hour 75 gr OGTT results were significantly higher in patients with BMI>25 (n=32 %39,5) (p25 (n=49 %60,5) serum levels of triglyseride were significantly higher than patients with BMI
🔬Design:Modeling & Simulation
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: to investigate the hormonal status, insulin resistance, clinical and metabolic parameters and their correlation in polycystic ovary syndrome (PCOS) patients. Material And Methods: The study was performed on a total of 81 patients with menstrual irregularity, hirsutism and obesity who were admitted to Zekai Tahir Burak Women s Health Educational and Research Hospital infertility and adolescent outpatient clinics between August 2010- August 2011. The serum levels of fasting insulin and glucose, 75 g oral glucose tolerance test (OGTT), low density lipoproteins (LDL), triglyseride (TG), high density lipoproteins (HDL), 17-hydroxyprogesterone, dehydroepiandrostenedione, androstenedione, total and free testosterone, thyroid stimulan hormon (TSH) were investigated, and body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) scores were calculated for all participants. Results : On Body Mass Index (BMI) match tests; serum levels of fasting glucose, fasting insulin and 2. hour 75 gr OGTT results were significantly higher in patients with BMI>25 (n=32 %39,5) (p25 (n=49 %60,5) serum levels of triglyseride were significantly higher than patients with BMI

Özet

Amaç: Polikistik over sendromu(PCOS) tanısı konulmuş bireylerde klinik, metabolik ve hormonal parametreler, insülin direnci araştırması ve birbiri ile ilişkilerini incelemekti. Yöntem ve Gereçler: Ağustos 2010- ağustos 2011 tarihleri arasında Zekai Tahir Burak Kadın Sağlığı ve Hastalıkları Hastanesi İnfertilite ve Gençlik Merkezi Polikliniklerine adet düzensizliği, tüylenmede artış, obezite şikâyetleri ile başvuran toplam 81 hastada da yapıldı. Tüm hastalarda serum açlık insülin ve glukoz, 75 gr. oral glukoz tolerans test (OGTT), düşük dansiteli lipoprotein (LDL), trigliserid (TG), yüksek dansiteli lipoprotein (HDL), 17-hidroksiprogesteron, dehidroepiandrostenedion, androstenedion, total ve serbest testosteron, tiroid stimulan hormon (TSH) seviyeleri araştırıldı. Vücut kitle indeksi (VKI) ve Homeostasis Model Assessment of İnsulin Resistance (HOMA-IR) skorları hesaplandı. Bulgular: VKI değerlendirmesinde VKI>25 (n=32 %39,5) olan hastalarda HOMA-lR skoru, açlık insülin seviyesi ve 2.saat 75 gr OGTT değeri, VKI25 olan gruba göre anlamlı derecede yüksek idi (p

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Cite This Article

ÖZAKŞİT, G., YAPAR, E. G. E., YILDIZ, Y., ENERGİN, H., ÖZGÜ, E., ÜNLÜ, B. S. (2022). Polikistik over hastalarında insulin direnci, metabolik durum ve metabolik parametreler arasındaki ilişki. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, Cilt: 9 - Sayı: 34, 1413–1420. https://ajindex.com/articles/558977

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References (1)

  1. Farah, L., et al., Prevalence of polycystic ovary syndrome in women seeking treatment from community electrologists. Alabama Professional Electrology Association Study Group. J Reprod Med, 1999. 44(10): p. 870-4. 2.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod, 2004. 19(1): p. 41-7. 3.Azziz, R., et al., Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab, 2006. 91(11): p. 4237-45. 4.Barbieri, R.L. and M.D. Hornstein, Hyperinsulinemia and ovarian hyperandrogenism. Cause and effect. Endocrinol Metab Clin North Am, 1988. 17(4): p. 685-703. 5.Arlt, W., R.J. Auchus, and W.L. Miller, Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3beta -hydroxysteroid dehydrogenase. J Biol Chem, 2001. 276(20): p. 16767-71. 6.Dunaif, A., et al., Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 1989. 38(9): p. 1165-74. 7.Beamer, B.A., et al., Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes, 1998. 47(11): p. 1806-8. 8.Crave, J.C., et al., Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. J Clin Endocrinol Metab, 1995. 80(7): p. 2057-62. 9.De Leo, V., A. la Marca, and F. Petraglia, Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev, 2003. 24(5): p. 633-67. 10.Poretsky, L., et al., Distribution and characterization of insulin and insulin-like growth factor I receptors in normal human ovary. J Clin Endocrinol Metab, 1985. 61(4): p. 728-34. 11.Poretsky, L., et al., The insulin-related ovarian regulatory system in health and disease. Endocr Rev, 1999. 20(4): p. 535-82. 12.Azziz, R., Androgen excess is the key element in polycystic ovary syndrome. Fertil Steril, 2003. 80(2): p. 252-4. 13.Talbott, E., et al., Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: results of a casecontrol study. J Clin Epidemiol, 1998. 51(5): p. 415-22. 14.Speroff L, Fritz MA. Clinical Gynecologic Endocrinology and Infertility. Seventh edition. Lippincott Williams and Wilkins Philadelphia 2005.p.502-503,471,488-490 15.Balen, A.H., et al., Polycysti