Journals / JAREM / 2018 / Cilt: 8 - Sayı: 2

Procalcitonin-Guided Antibiotic Treatment in Lower Respiratory Tract Infections

Prokalsitonin Rehberliğinde Alt Solunum Yolu Enfeksiyonları Antibiyotik Tedavisi

Journal
JAREM
Pages
72–78
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In theCAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presenceof infection.
📊
Key Findings & Data:The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections.Methods: A total of 78 patients with community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD) exacerbations, andhealthy controls were evaluated.
💡
Conclusion & Impact:In theCAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Procalcitonin (PCT), C-reactive protein (CRP), and leukocyte count are important host response biomarkers to determine the presenceof infection. The aim of the present study was to evaluate the usefulness of PCT with other markers in lower respiratory tract infections.Methods: A total of 78 patients with community-acquired pneumonia (CAP), chronic obstructive pulmonary disease (COPD) exacerbations, andhealthy controls were evaluated. Baseline serum levels of PCT and CRP and leukocyte counts were assessed and repeated on day 7 of antibiotictreatment.Results: Procalcitonin levels and absolute neutrophil counts (ANCs) were higher in the CAP and COPD groups than in the control group. In theCAP and COPD exacerbation groups, the leukocyte count, ANC, and CRP and PCT levels decreased on day 7 of the treatment (p

Özet

Amaç: Prokalsitonin (PCT), C-reaktif protein (CRP) ve lökosit sayısı gibi enfeksiyon durumunda serumda artış gösteren önemli bir biyo-belirteçtir. Ancak alt solunum yolu enfeksiyonlarının ayırıcı tanısında PCT’nin değeri tam bilinmemektedir. Alt solunum yolu enfeksiyonlarında antibiyotik başlama ve sonlandırma konusunda PCT ve diğer biyo-belirteçlerin yerini irdelemeyi amaçladık. Yöntemler: Yetmiş sekiz hasta (30 pnömoni, 24 kronik obstrüktif akciğer hastalığı [KOAH] alevlenme, 24 sağlıklı kontrol) değerlendirildi. Demografik ve klinik özellikler, laboratuar sonuçları değerlendirildi. Bazal PCT, lökosit, CRP sonuçlarına bakıldı ve bu sonuçlar tedavinin 7. gününde tekrarlandı. Bulgular: Kontrol grubuyla kıyaslandığında nötrofil sayısı, lökosit sayısı ve PCT değeri daha yüksek bulunmuştur. Pnomoni ve KOAH alevlenme grubunda 7. günün sonunda lökosit sayısı, CRP ve PCT değerinde anlamlı ölçüde düşme olduğu gözlendi (p

🔖

Cite This Article

BALCAN, B., BALCI, M. K., CEYHAN, B., YILDIZELİ, Ş. O. (2022). Procalcitonin-Guided Antibiotic Treatment in Lower Respiratory Tract Infections. JAREM, Cilt: 8 - Sayı: 2, 72–78. https://ajindex.com/articles/558234

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (2)

  1. Mizgerd JP. Acute lower respiratory tract infection. N Engl J Med. 2008;358:716-27. [CrossRef] Welte T, Torres A, Nathwani D. Clinical and economic burden of community-acquired pneumonia among adults in Europe. Thorax. 2012;67:71-9. [CrossRef] Niederman MS, Mandell LA, Anzueto A, Bass JB, Broughton WA, Campbell GD, Dean N, File T, Fine MJ, Gross PA, et al. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med. 2001;163:1730-54. [CrossRef] Irfan M, Farooqi J, Hasan R. Community-acquired pneumonia. Curr Opin Pulm Med. 2013;19:198-208. [CrossRef] Wenzel RP. The antibiotic pipeline--challenges, costs, and values. N Engl J Med. 2004;351:523-6. [CrossRef] Marras TK, Gutierrez C, Chan CK. Applying a prediction rule to identify low-risk patients with community-acquired pneumonia. Chest. 2000;118:1339-43. [CrossRef] Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, Lewis SA, Macfarlane JT. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003;58:377-82. [CrossRef] Chalmers JD, Mandal P, Singanayagam A, Akram AR, Choudhury G, Short PM, Hill AT. Severity assessment tools to guide ICU admission in community-acquired pneumonia: systematic review and metaanalysis. Intensive Care Med. 2011;37:1409-20. [CrossRef] Prkno A, Wacker C, Brunkhorst FM, Schlattmann P. Procalcitoninguided therapy in intensive care unit patients with severe sepsis and septic shock--a systematic review and meta-analysis. Crit Care. 2013;17:R291. [CrossRef] Le Moullec JM, Jullienne A, Chenais J, Lasmoles F, Guliana JM, Milhaud G, Moukhtar MS. The complete sequence of human preprocalcitonin. FEBS Lett. 1984;167:93-7. [CrossRef] Muller B, Becker KL. Procalcitonin: how a hormone became a marker and mediator of sepsis. Swiss Med Wkly. 2001;131:595-602.
  2. Muller B, Becker KL, Schachinger H, Rickenbacher PR, Huber PR, Zimmerli W, Ritz R. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med. 2000;28:977-83. [CrossRef] Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med. 2006;34:1996-2003. [CrossRef] Weidner W, Wagenlehner FM. Re: Procalcitonin as a diagnostic marker for sepsis: a systematic