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Journals / JAREM / 2020 / Cilt: 10 - Sayı: 2

Effects of Leptin, Resistin, and PPAR-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population

Akut Koroner Sendromu Bulunan Obez Türk Hastalarda Leptin, Rezistin ve PPAR-Gama Gen Varyantlarının Etkileri

Osman FAZLIOĞULLARI
Cem BAŞARAN
Akif ARAT
Ümit ZEYBEK
Nesibe YILMAZ
Faruk ÇELİK
Journal
JAREM
Pages
166–174
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Keywords: Acute coronary syndrome, leptin, resistin, PPAR-γ, gene polymorphism, PCR-RFLP

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years.
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Key Findings & Data:This study aimed to investigate the association of Leptin glutamine to arginine substitution (Gln223Arg), Resistin-420 Cytosine/Guanine (C/G), and proliferator-activated receptor-gamma (PPAR-γ) proline to alanine substitution (Pro12Ala) polymorphisms in obese patients with ACS in the Turkish population.
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Conclusion & Impact:Keywords: Acute coronary syndrome, leptin, resistin, PPAR-γ, gene polymorphism, PCR-RFLP
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Obesity and acute coronary syndrome (ACS) are common health problems of recent years. There are many candidate genes related to the genetic infrastructure of ACS and obesity. This study aimed to investigate the association of Leptin glutamine to arginine substitution (Gln223Arg), Resistin-420 Cytosine/Guanine (C/G), and proliferator-activated receptor-gamma (PPAR-γ) proline to alanine substitution (Pro12Ala) polymorphisms in obese patients with ACS in the Turkish population. Methods: Fifty obese patients concurrently diagnosed with ACS and 42 healthy controls were included in this study. These polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism and agarose gel electrophoresis methods. Results: The PPAR-γ Pro12Ala polymorphism Pro/Ala genotype (p=0.001) was found to be higher in the obese patients with ACS, while the (Proline/ Proline) genotype (p=0.001) was significantly higher in the control group. The GC genotype (p=0.045) distribution of Resistin-420 C/G was found to be significantly higher in the controls compared to the patient group. Conclusion: Our study presents new findings that the PPAR-γ Pro12Ala polymorphism Pro/Ala genotype is a risk factor for ACS in obese individuals, whereas Resistin-420 C/G polymorphism GC genotype and PPAR-γ Pro12Ala polymorphism Pro/Pro genotype may be protective factors for ACS in obese individuals. Keywords: Acute coronary syndrome, leptin, resistin, PPAR-γ, gene polymorphism, PCR-RFLP

Özet

Amaç: Obezite ve akut koroner sendrom (AKS) son yılların yaygın sağlık problemlerindendir. AKS ve obezitenin genetik altyapısı ile ilgili bir çok aday gen bildirilmektedir. Bu çalışmanın amacı, Türk popülasyonundaki AKS’li obez hastalarda Leptin glutamin-arginin substitution (Gln223Arg), Rezistin -420 Sitozin/Guanin (C/G) ve proliferatör ile aktive edilen reseptör gama (PPAR-γ) prolin-alanin substitution (Pro12Ala) polimorfizmlerinin etkilerini incelemektir. Yöntemler: Çalışmaya AKS tanısı konmuş 50 obez hasta ve 42 sağlıklı kontrol dahil edilmiştir. Polimorfizmler polimeraz zincir reaksiyonu-restriksiyon parça uzunluk polimorfizmi (PZR-RFLP) ve agaroz jel elektroforezi metotları kullanılarak analiz edildi. Bulgular: PPAR-γ Pro12Ala polimorfizmi için Pro/Ala (p=0,001) genotipi taşıma oranı hasta grubunda kontrol grubuna göre, Proline/Proline (Pro/Pro) genotipi (p=0,001) taşıma oranı ise hasta grubuna oranla kontrol grubunda anlamlı düzeyde daha yüksektir. Rezistin -420 C/G polimorfizminin GC genotip (p=0,045) dağılımı ise hasta grubu ile kıyaslandığında kontrol grubunda anlamlı olarak yüksek bulundu.

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Cite This Article

FAZLIOĞULLARI, O., BAŞARAN, C., ARAT, A., ZEYBEK, Ü., YILMAZ, N., ÇELİK, F. (2022). Effects of Leptin, Resistin, and PPAR-Gama Gene Variants on Obese Patients with Acute Coronary Syndrome in the Turkish Population. JAREM, Cilt: 10 - Sayı: 2, 166–174. https://ajindex.com/articles/558201

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