Journals / JAREM / 2021 / Cilt: 11 - Sayı: 2

Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis

Juvenil İdiyopatik Artrit Aktivitesi ile İlişkili Serum Visfatin ve Adiponektin Düzeylerinin Değerlendirilmesi

Journal
JAREM
Pages
120–125
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Significant differences were found in serum visfatin levels between the active and the control groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to investigate the possible relationship of serum adiponectin and visfatin levels that are derived from the adipose tissue in patients with juvenile idiopathic arthritis (JIA), in accordance with the routinely used biochemical parameters, to evaluate the management of therapy and assessment of disease activity.
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Key Findings & Data:Complete blood count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were routinely measured.
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Conclusion & Impact:Results: Significant differences were found in serum visfatin levels between the active and the control groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to investigate the possible relationship of serum adiponectin and visfatin levels that are derived from the adipose tissue in patients with juvenile idiopathic arthritis (JIA), in accordance with the routinely used biochemical parameters, to evaluate the management of therapy and assessment of disease activity. Methods: According to the Wallace criteria, the study population was divided into active, remission and control groups. Serum adiponectin and visfatin levels were measured by the enzyme-linked immunosorbent assay method. Complete blood count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were routinely measured. Neutrophil/lymphocyte ratio (NLR) was calculated. Results: Significant differences were found in serum visfatin levels between the active and the control groups (p

Özet

biyokimyasal parametrelerle karşılaştırarak değerlendirmek ve hastalık aktivitesi ile tedavinin izlenmesinde bu iki parametrenin rolünü araştırmaktır. Yöntemler: Wallace kriterlerine göre; çalışma grubu aktif, remisyon ve kontrol gruplarından oluşmaktadır. Serum adiponektin ve visfatin seviyeleri enzime bağlı immunosorbent test yöntemi ile analiz edilmiştir. Tam kan sayımı, eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) rutin olarak ölçüldü. Nötrofil/lenfosit oranı (NLO) hesaplandı. Bulgular: Aktif ve kontrol grupları arasında serum visfatin düzeylerinde istatistiksel olarak anlamlı farklılık bulunurken (p

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Cite This Article

BARUT, K., ŞAHİN, S., KASAPÇOPUR, Ö., YILDIZ, A. A., DÜMÜR, Ş., KUCUR, M., EKMEKÇİ, H., ÇALIŞKAN, O., GÜNGÖR, Z. B., EKMEKÇİ, Ö. B. (2022). Evaluation of the Serum Visfatin and Adiponectin Levels Related with the Activity of Juvenile Idiopathic Arthritis. JAREM, Cilt: 11 - Sayı: 2, 120–125. https://ajindex.com/articles/558153

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References (13)

  1. Barut K, Adrovic A, Şahin S, Kasapçopur Ö. Juvenile idiopathic arthritis. Balkan Med J 2017; 34: 90-101
  2. Wallace CA, Huang B, Bandeira M, Ravelli A, Giannini EH. Patterns of clinical remission in select categories of juvenile idiopathic arthritis. Arthritis Rheum 2005; 52: 3554-62
  3. Kessel C, Holzinger D, Foell D. Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers. Clin Immunol 2013; 147: 229-41
  4. Frizinsky S, Haj-Yahia S, Machnes Maayan D, Lifshitz Y, Maoz-Segal R, Offengenden I, et al. The innate immune perspective of autoimmune and autoinflammatory conditions. Rheumatology (Oxford) 2019; 58(Suppl 6): vi1-8
  5. Shoop-Worrall SJW, Kearsley-Fleet L, Thomson W, Verstappen SMM, Hyrich KL. How common is remission in juvenile idiopathic arthritis: a systematic review. Semin Arthritis Rheum 2017; 47: 331-7
  6. Naz S, Aslam R, Ullah E, Shahzad F, Mushtaq A, Ahmad TM, et al. Association of erythrocyte sedimentation rate and c-reactive proteins with active disease in Juvenile Rheumatoid Arthritis. Pak Pediatr J 2014; 38: 24-30. 7. Żółkiewicz J, Stochmal A, Rudnicka L. The role of adipokines in systemic sclerosis: a missing link? Arch Dermatol Res 2019; 311: 251-63
  7. Landecho MF, Tuero C, Valentí V, Bilbao I, de la Higuera M, Frühbeck G. Relevance of leptin and other adipokines in obesity-associated cardiovascular risk. Nutrients 2019; 11: 2664
  8. Fatel ECS, Rosa FT, Simão ANC, Dichi I. Adipokines in rheumatoid arthritis. Adv Rheumatol 2018; 58: 25
  9. Scotece M, Conde J, López V, Lago F, Pino J, Gómez-Reino JJ, et al. Adiponectin and leptin: new targets in inflammation. Basic Clin Pharmacol Toxicol 2014; 114: 97-102
  10. Abella V, Scotece M, Conde J, López V, Lazzaro V, Pino J, et al. Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res 2014; 2014: 343746. doi: 10.1155/2014/343746
  11. Moschen AR, Kaser A, Enrich B, Mosheimer B, Theurl M, Niederegger H, et al. Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol 2007; 178: 1748-58
  12. Kim SR, Bae YH, Bae SK, Choi KS, Yoon KH, Koo TH, et al. Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NFKB activation in endothelial cells. Biochim Biophys Acta 2008; 1783: 886-95
  13. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of