Journals / İzmir Tepecik Eğitim Hastanesi Dergisi / 2022 / Cilt: 32 - Sayı: 1

Effects of Anemia on Overall Survival in Muscle Invasive Bladder Cancer

Aneminin Kas İnvaziv Mesane Kanserinde Genel Sağkalım Üzerine Etkisi

Pages
115–121
Publication Date
2022-10-18
DOI
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Objective: The aim of this study was to investigate the effect of preoperative anemia on overall survival in patients with muscle-invasive bladder cancer.

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Objective & Hypothesis:Objective: The aim of this study was to investigate the effect of preoperative anemia on overall survival in patients with muscle-invasive bladder cancer.
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Key Findings & Data:Results: A statistically significant difference was found between the groups in terms of overall survival.
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Conclusion & Impact:We consider that preoperative anemia and pT stage are variables that can be used to predict overall survival
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the effect of preoperative anemia on overall survival in patients with muscle-invasive bladder cancer. Methods: We retrospectively analyzed the medical data of patients with a diagnosis of muscle-invasive bladder cancer who underwent consecutive cystectomy. The patients were divided into two groups as those with and without anemia before the operation. These two groups were compared in terms of age, gender, smoking status, American Society of Anesthesiologists score, the history of neoadjuvant chemotherapy, pathological tumor (pT) stage, pathological node stage, number of lymph nodes removed, positive surgical margin, concomitant carcinoma in situ (CIS) presence, lymphovascular invasion, perineural invasion, history of adjuvant chemotherapy, overall survival, recurrence status, urinary diversion type, tumor multiplicity and grade. Results: A statistically significant difference was found between the groups in terms of overall survival. There was no statistically significant difference between the groups in terms of other variables. Overall survival in group 1 was 61.8 months, and overall survival in group 2 was 32.6 months. Overall survival in all patients was 47.9 months. Five-year overall survival was 54% in group 1 and 20% in group 2. Conclusion: We detected that the presence of preoperative anemia was associated with poor overall survival rates in patients with muscle-invasive bladder cancer. We consider that preoperative anemia and pT stage are variables that can be used to predict overall survival

Özet

Amaç: Bu çalışmanın amacı kasa invaziv mesane kanserli hastalarda preoperatif aneminin genel sağkalıma etkisini araştırmaktır. Yöntem: Kas invaziv mesane kanseri tanısı olan ardışık sistektomi yapılan hastaların tıbbi verilerini geriye dönük olarak inceledik. Hastalar operasyon öncesi anemisi olanlar ve olmayanlar olarak iki gruba ayrıldı. Bu iki grup yaş, cinsiyet, sigara içme durumu, American Society of Anesthesiologists skoru, neoadjuvan kemoterapi öyküsü, patolojik tümör (pT) evresi, patolojik nod evresi, çıkarılan lenf nodu sayısı, cerrahi sınır, eşlik eden karsinoma in situ (CIS) varlığı, lenfovasküler invazyon, perinöral invazyon, adjuvan kemoterapi öyküsü, genel sağkalım, nüks durumu, üriner diversiyon tipi, tümör çokluğu ve derecesi açısından karşılaştırıldı. Bulgular: Genel sağkalım açısından gruplar arasında istatistiksel olarak anlamlı fark bulundu. Diğer değişkenler açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu. Grup 1’de genel sağkalım 61,8 ay ve grup 2’de genel sağkalım 32,6 ay idi. Tüm hastalarda genel sağkalım 47,9 aydı. Beş yıllık genel sağkalım grup 1’de %54 ve grup 2’de %20 idi. Sonuç: Kasa invaziv mesane kanserli hastalarda preoperatif anemi varlığının kötü genel sağkalım oranları ile ilişkili olduğunu saptadık. Preoperatif anemi ve pT evresinin genel sağkalımı tahmin etmek için kullanılabilecek değişkenler olduğunu düşünüyoruz.

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Cite This Article

YOLDAŞ, M., KARABACAK, M. C., KESKİN, M. Z., İLBEY, Y. Ö., YALÇIN, M. Y., MİÇOOĞULLARI, U., YÜCEL, E. E., SEZER, S. D. (2022). Effects of Anemia on Overall Survival in Muscle Invasive Bladder Cancer. İzmir Tepecik Eğitim Hastanesi Dergisi, Cilt: 32 - Sayı: 1, 115–121. https://ajindex.com/articles/558022

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