RELATIONSHIP BETWEEN CIRCULATING BETATROPHIN LEVELS AND INSULIN RESISTANCE IN PREDIABETIC SUBJECTS

Insulin resistance was evaluated usingthe HOMA-IR index.Results: Serum betatrophin levels were significantly higher in prediabetic subjects compared with normalglucose-tolerant subjects (p

📌 3 Key Takeaways

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Objective & Hypothesis:nroduction: Betatrophin [also known as RIFL, lipasin, ANGPTL8, TD26] is newly appreciated for its role as apotent inducer of beta cell proliferation in mice.

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Key Findings & Data:Its expression is increased upon insulin resistance.We here aimedto determine the serum levels of this hormone in prediabetic subjects and to investigate its relationship withmetabolic parameters.Material and Methods: The research was designed as a case-control study, in which 42 subjects withprediabetes and 37 with normal glucose tolerance were consecutively recruited, in an attempt to match thegroups for age, sex and body mass index (BMI).

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Conclusion & Impact:Insulin resistance was evaluated usingthe HOMA-IR index.Results: Serum betatrophin levels were significantly higher in prediabetic subjects compared with normalglucose-tolerant subjects (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

nroduction: Betatrophin [also known as RIFL, lipasin, ANGPTL8, TD26] is newly appreciated for its role as apotent inducer of beta cell proliferation in mice. Its expression is increased upon insulin resistance.We here aimedto determine the serum levels of this hormone in prediabetic subjects and to investigate its relationship withmetabolic parameters.Material and Methods: The research was designed as a case-control study, in which 42 subjects withprediabetes and 37 with normal glucose tolerance were consecutively recruited, in an attempt to match thegroups for age, sex and body mass index (BMI). Serum betatrophin, insulin, C-peptide, fasting blood glucose,HbA1c, high-sensitivity C-reactive protein, and lipid levels were measured. Insulin resistance was evaluated usingthe HOMA-IR index.Results: Serum betatrophin levels were significantly higher in prediabetic subjects compared with normalglucose-tolerant subjects (p

Özet

Giriş: Betatrophin farelerde beta hücrelerinde proliferasyona neden olmakta ve insulin direnci ile sentezi artmaktadır. Araştırmamızda prediyabetik hastalarda serum betatrophin düzeyini incelemeyi ve betatrophinin metabolik parametreler ile ilişkisini incelemeyi amaçladık. Gereç ve Yöntem: Vaka kontrollü olarak planladığımız araştırmamıza; 42 prediyabetik hasta ve yaşı, çinsiyeti ve vücut kitle indexi (VKİ) uygun olan 37 gönüllü glukoz metabolizması normal olan birey alındı. Araştırmaya dâhil edilen bireylerin betatrophin, insulin, C-peptit, açlık kan glikozu, HbA1c, hs-CRP ve lipid düzeyleri ölçüldü. Bireylerin insulin dirençleri HOMA-IR indexi ile hesaplandı. Bulgular: Serum betatrophin düzeyi prediyabetik bireylerde kontrol grubundaki bireylere göre istatistiksel olarak anlamlı yüksek bulundu (p

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Cite This Article

ARKAN, T., ÇALAN, M., BAYINDIR, A. G., IŞIL, A. M., YEŞİL, P., DOKUZLAR, Ö., BAYRAKTAR, F., KÜME, T. (2022). RELATIONSHIP BETWEEN CIRCULATING BETATROPHIN LEVELS AND INSULIN RESISTANCE IN PREDIABETIC SUBJECTS. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 21 - Sayı: 2, 29–36. https://ajindex.com/articles/557793

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