Journals / İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi / 2019 / Cilt: 9 - Sayı: 3

Comparison of the Efficacy of Daily and Weekly Oral Alendronate Treatment in Patients with Secondary Osteoporosis

Sekonder Osteoporozlu Hastalarda Günlük ve Haftalık Oral Alendronat Tedavisinin Etkinliğinin Karşılaştırılması

Pages
191–198
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

BMD z-score increased from-3.41±0.50 to -0.50±0.67 in the group receiving daily treatment (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The use of alendronate, one of the bisphosphonates that can be used orally in the treatment ofosteoporosis, has become widespread in recent years.
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Key Findings & Data:Clinical and laboratory features,bone mineral density (BMD) measurements of cases were retrieved from file records.Results: This study included 28 children who were diagnosed with secondary osteoporosis due to variouschronic diseases and who received weekly (n=15) or daily (n=13) alendronate.
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Conclusion & Impact:BMD z-score increased from-3.41±0.50 to -0.50±0.67 in the group receiving daily treatment (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The use of alendronate, one of the bisphosphonates that can be used orally in the treatment ofosteoporosis, has become widespread in recent years. In this study, we aimed to compare the efficacy ofthese two different treatment regimens such as weekly and daily oral alendronate in patients with secondary osteoporosis.Method: Twenty-eight children and adolescent who were treated with oral daily or weekly alendronatewith the diagnosis of secondary osteoporosis were included in this study. Clinical and laboratory features,bone mineral density (BMD) measurements of cases were retrieved from file records.Results: This study included 28 children who were diagnosed with secondary osteoporosis due to variouschronic diseases and who received weekly (n=15) or daily (n=13) alendronate. BMD z-score increased from-3.41±0.50 to -0.50±0.67 in the group receiving daily treatment (p

Özet

Amaç: Osteoporoz tedavisinde oral olarak kullanılabilen bisfosfonatlardan biri olan alendronatın kullanımı son yıllarda yaygınlaşmıştır. Bu çalışmada, sekonder osteoporozlu hastalarda, haftalık ve günlük oral alendronat tedavi rejimlerinin etkinliğini karşılaştırmayı amaçladık. Yöntem: Sekonder osteoporoz tanısı ile günlük veya haftalık alendronat ile tedavi edilen 28 çocuk ve adolesan çalışmaya dahil edildi. Dosya kayıtlarından klinik ve laboratuvar özellikleri, kemik mineral yoğunluğu (KMY) ölçümleri kaydedildi. Bulgular: Çalışmaya çeşitli kronik hastalıklara bağlı sekonder osteoporoz tanısı konulan ve haftalık (n=15) veya günlük (n=13) alendronat tedavisi alan 28 çocuk alındı. KMY z-skorları, günlük tedavi alan grupta -3,41±0,50’den -0,50±0,67’ye (p

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Cite This Article

DEMİR, K., ABACI, A., ACAR, S., BÖBER, E., PAKETÇİ, A. (2022). Comparison of the Efficacy of Daily and Weekly Oral Alendronate Treatment in Patients with Secondary Osteoporosis. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, Cilt: 9 - Sayı: 3, 191–198. https://ajindex.com/articles/557675

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References (9)

  1. Ward L, Tricco AC, Phuong P, et al. Bisphosphonate therapy for children and adolescents with secondary osteoporosis. Cochrane Database Syst Rev. 2007;4:CD005324.
  2. Ward LM, Konji VN, Ma J. The management of osteoporosis in children. Osteoporos Int. 2016;27:2147-79.
  3. Paksu MS, Vurucu S, Karaoglu A, et al. Osteopenia in children with cerebral palsy can be treated with oral alendronate. Childs Nerv Syst. 2012;28:283-6.
  4. Unal E, Abaci A, Bober E, Buyukgebiz A. Efficacy and safety of oral alendronate treatment in children and adolescents with osteoporosis. J Pediatr Endocrinol Metab. 2006;19:523-8
  5. Apkon S, Coll J. Use of weekly alendronate to treat osteoporosis in boys with muscular dystrophy. Am J Phys Med Rehabil. 2008;87:139-43.
  6. Chesnut CH, McClung MR, Ensrud KE, et al. Alendronate treatment of the postmenopausal osteoporotic woman: effect of multiple dosages on bone mass and bone remodeling. Am J Med. 1995;99:144-52.
  7. Liberman UA, Weiss SR, Broll J, et al. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med. 1995;333:1437-43.
  8. Sağlam H, Eren E, Papatya Çakır ED, Özboyacı E, Özgür T, Tarım Ö. The efficacy of alendronate in shildren with secondary osteoporosis. J Curr Pediatr. 2010;8:86-9. Available from:http:// http://www.guncelpediatri.com/ makale_830/Sekonder-Osteoporozlu-CocuklardaAlendronat-Tedavisinin-Etkinligi-Ozgun-Arastirma.html 9. Bianchi ML, Cimaz R, Bardare M, et al. Efficacy and safety of alendronate for the treatment of osteoporosis in diffuse connective tissue diseases in children: a prospective multicenter study. Arthritis Rheum. 2000;43:1960-6. https://doi.org/10.1002/1529-0131(200009)43:9 3.0.CO;2-J 10. Rudge S, Hailwood S, Horne A, Lucas J, Wu F, Cundy T. Effects of once-weekly oral alendronate on bone in children on glucocorticoid treatment. Rheumatology (Oxford). 2005;44:813-8.
  9. Baim S, Leonard MB, Bianchi ML, et al. Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Pediatric Position Development Conference. J Clin D