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Journals / İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası / 2004 / Cilt: 67 - Sayı: 3

Hypertension and body fat amount and distribution in obese women

Fazla kilolu şişman kadınlarda hipertansiyon sıklığı ve metabolik sendrom

Sertkaya Ayşe ÇIKIM
Ferhan MANTAR
Neşe ÖZBEY
Yusuf ORHAN
Pages
140–144
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The high levels of insulin and HOMA in hypertensive patients have suggested that insulin resistance could play a role in the pathogenesis of this syndrome.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study is to examine incidence of hypertension and its relationship with body fat amount and distribution in obese women.
📊
Key Findings & Data:Hypertension was defined as blood pressure > 140/90 mm Hg.
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Conclusion & Impact:The high levels of insulin and HOMA in hypertensive patients have suggested that insulin resistance could play a role in the pathogenesis of this syndrome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The aim of this study is to examine incidence of hypertension and its relationship with body fat amount and distribution in obese women. Hypertension was defined as blood pressure > 140/90 mm Hg. Study group consisted of 646 overweight (body mass index, BMI >25 kg/m2) and 2539 obese (body mass index, BMI > 30 kg/m2) women. Hypertension was found in 1388 (%43.61) women. Age (43.04 ± 12.44 vs 36.41 ± 11.28 years), weight (93.38 ± 18.11 vs 84.78 ve 14.36 kg), BMI (37.94 ± 7.15 vs 34.07 + 6.94 kg/m2), waist circumference (103.20 ± 13.38 vs 95.90 + 11.80 cm), hip circumference (123.96 + 13.78 vs 118.20 ± 11.40 cm), waist-to-hip ratio (0.834 ± 0.077 vs 0.811 ± 0.066), glucose (106.22 ± 32.76 vs 96.14 ± 22.63 mg/dL), uric acid (4.77 ± 1.36 vs 4.24 + 1.13 mg/dL), cholesterol (217.17 + 45.89 vs 201.29 ± 43.63 mg/dL), triglyceri-de (178.64 + 140.53 vs 145.00 ± 103.78 mg/dL), insulin (17.67 ± 16.40 vs 13.60 ± 11.51 uU/dL), HOMA (4.68 ± 4.83 vs 3.21 ± 3.22), gamma GT (23.55 + 18.42 vs 20.68 ± 15.01 U/dL) and total risk score (1.89 ± 1.15 vs 1.34 + 1.06) levels were significantly higher in hypertensive groups than thosein normotensives (p < 0.001 for gamma GT and p < .0001 for others). These metabolic anomalies that constitute a cluster of phenomena are known as pluri-metabolic syndrome. The high levels of insulin and HOMA in hypertensive patients have suggested that insulin resistance could play a role in the pathogenesis of this syndrome.

Özet

Bu çalışma şişman kadınlarda hipertansiyon sıklığını ve damar basıncı ile çeşitli risk göstergeleri arasındaki ilişkiyi incelemek amacıyla yapıldı. Damar basıncının 140/90 mm Hg in üzerinde olması hipertansiyon kriteri olarak kabul edildi. 646 fazla kilolu (beden kitle indeksi, body mass index, BMI > 25 kg/m2) ve 2537 şişman (BMI > 30 kg/m2) toplam 3183 kadından 1388 inde (%43.66) hipertansiyon saptandı. Hipertansif kadınlarda damar basıncı normal olanlara göre yaş (43.04 ± 12.44 ve 36.41 ± 11.28 yıl), ağırlık (93.38 + 18.11 ve 84.78 ve 14.36 kg), BMI (37.94 ± 7.15 ve 34.07 + 6.94 kg/m2), bel çevresi (103.20 ± 13.38 ve 95.90 + 11.80 cm), kalça çevresi (123.96 ± 13.78 ve 118.20 ± 11.40 cm), bel-kalça oranı (0.834 ± 0.077 ve 0.811 ± 0.066), glukoz (106.22 ± 32.76 ve 96.14 ± 22.63 mg/dL), ürik asit (4.77 ± 1.36 ve 4.24 ± 1.13 mg/dL), kolesterol (217.17 ± 45.89 ve 201.29 ± 43.63 mg/dL), trigliserit (178.64 + 140.53 ve 145.00 + 103.78 mg/dL), insülin (17.67 ± 16.40 ve 13.60 ± 11.51 uU/L), HOMA (4.68 ± 4.83 ve -3.21 ± 3.22), gama GT (23.55 ± 18.42 ve 20.68 ± 15.01 U/L) ve toplam risk değeri (1.89 ± 1.15 ve 1.34 ± 1.06) anlamlı daha yüksekti (p değeri gama GT için 0.001, diğerleri için 0.0001). HDL değerleri bakımından anlamlı bir farklılık bulunmadı. Hipertansif hastalarda diğer risk faktörlerinin birlikte bulunması metabolik sendrom varlığını destekler bulgu olarak kabul edildi. İnsülin ve. HOMA düzeylerinin yüksek bulunması metabolik sendrom pa-togenezinde insülin direncinin yer alabileceğini düşündürmektedir.

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Cite This Article

ÇIKIM, S. A., MANTAR, F., ÖZBEY, N., ORHAN, Y. (2022). Hypertension and body fat amount and distribution in obese women. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası, Cilt: 67 - Sayı: 3, 140–144. https://ajindex.com/articles/553655

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