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Journals / İstanbul Medical Journal / 2020 / Cilt: 21 - Sayı: 1

The Evaluation of Thrombospondin 1 Levels in Patients with Acromegaly

Akromegali Hastalarında Thrombospondin 1 Düzeylerinin Değerlendirilmesi

Ayfer Çolak
Mustafa Demirpençe
Hamiyet Yılmaz
Merve Zeytinli
Barış Önder Pamuk
Demet İnce
Pages
13–17
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fifty-twopatients with active acromegaly with GH

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Acromegaly is a rare disease caused byoverproduction of growth hormone (GH) secreted froma benign pituitary adenoma.
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Key Findings & Data:It has been shown in manystudies that the incidence of cancer is increased in patientswith acromegaly with increased GH and insulin-like growthfactor-1 (IGF-1).
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Conclusion & Impact:Fifty-twopatients with active acromegaly with GH
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Acromegaly is a rare disease caused byoverproduction of growth hormone (GH) secreted froma benign pituitary adenoma. It has been shown in manystudies that the incidence of cancer is increased in patientswith acromegaly with increased GH and insulin-like growthfactor-1 (IGF-1). Especially, colon cancer is more common.Thrombospondin-1 (TSP-1) is a glycoprotein that is thought toplay an important role in cancer formation. This study aimedto evaluate circulating TSP-1 levels in patients with acromegaly.Methods: This study was a case-control study. Fifty-twopatients with active acromegaly with GH

Özet

Amaç: Akromegali genellikle iyi huylu hipofiz adenomundan salgılanan büyüme hormonunun (BH) aşırı üretimi sonucu ortaya çıkan nadir bir hastalıktır. Akromegali hastalarında artmış BH ve insülin benzeri büyüme faktörü-1 (IGF-1) ile kanser görülme sıklığının da arttığı birçok çalışmada gösterilmiştir. Özellikle kolon kanserleri daha sık görülmektedir. Trombospondin-1 (TSP-1) kanser oluşumunda önemli bir rol oynadığı düşünülen bir glikoproteindir. Bu çalışmada akromegali hastalarında dolaşımdaki TSP-1 düzeylerinin değerlendirilmesi amaçlanmıştır. Yöntemler: Bu bir olgu kontrol çalışmasıdır. Çalışmamıza takip altında olan BH

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Cite This Article

Çolak, A., Demirpençe, M., Yılmaz, H., Zeytinli, M., Pamuk, B. Ö., İnce, D. (2022). The Evaluation of Thrombospondin 1 Levels in Patients with Acromegaly. İstanbul Medical Journal, Cilt: 21 - Sayı: 1, 13–17. https://ajindex.com/articles/552313

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