Journals / İstanbul Medical Journal / 2013 / Cilt: 14 - Sayı: 4

The Relationship between Microalbuminuria, Insulin Resistance and Renal Blood Flow in Patients with Primary Hypertension

Esansiyel Hipertansiyonu Olan Hastalarda Mikroalbüminüri, İnsülin Direnci ve Renal Kan Akımı Arasındaki İlişkinin İrdelenmesi

Pages
266–270
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, therewas no relationship between RI and gender, microalbuminuria or insulinresistance.

📌 3 Key Takeaways

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Objective & Hypothesis:Prevalence of hypertension is increasing and it is a commonhealth problem which leads to damage in several organs.
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Key Findings & Data:Also the effect of age and gender on RIvalue was studied.Results: A total of 42 women and 38 men with hypertension were studied.Mean age of the patients was 51.9±9.5; 49 of them were over 50 years.Thirty two patients had microalbuminuria and 17 of these patients wereover 50 years.
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Conclusion & Impact:However, therewas no relationship between RI and gender, microalbuminuria or insulinresistance.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Prevalence of hypertension is increasing and it is a commonhealth problem which leads to damage in several organs. High blood pressureaffects several organ systems; one of which is the kidney. Currentlymicroalbuminuria is increasingly used as an indicator of renal damage.Insulin resistance is one of the factors that plays a role in the pathogenesisof hypertension. There is an inverse relationship between renal blood flowand resistivity index by renal doppler untrosonography. The aim of thisstudy is to examine the relationship between microalbuminuria, insulinresistance and renal blood flow- RI in patients with primary hypertension.Methods: Eighty patients with essential hypertension were included inour study. Microalbuminuria was measured on spot urine. Homa-IR forinsulin resistance was calculated by glucose and insulin levels at fastingblood glucose. RI was investigateded by renal doppler ultrasonography.RI values were compared in patients with/without microalbuminuria andwith/ without insulin resistance. Also the effect of age and gender on RIvalue was studied.Results: A total of 42 women and 38 men with hypertension were studied.Mean age of the patients was 51.9±9.5; 49 of them were over 50 years.Thirty two patients had microalbuminuria and 17 of these patients wereover 50 years. An elevated RI value was observed in 7 patients and allof them were over 50 years. There was no correlation between RI andmicroalbuminuria.Conclusion: We found elevated RI values in older patients. However, therewas no relationship between RI and gender, microalbuminuria or insulinresistance.

Özet

Hipertansiyon birçok organda hasara neden olan ve prevalansı giderek artan bir sağlık sorunudur. Organizmada bir çok sistemi etkiler; bunlardan biri de böbreklerdir. Renal hasarın öngörülmesinde son zamanlarda mikroalbuminüri yaygın olarak kullanılmaktadır. İnsülin direnci hipertansiyon potogenezinde rol oynayan faktörlerdendir. Renal dopplerle bakılan resistivite indeksi (RI) ile renal akımı arasında ters orantılı bir ilişki vardır. Biz de çalışmamızda esansiyel hipertansiyonlu olgularda renal kan akımı -RI, insülin direnci ve mikroalbuminüri arasındaki ilişkiyi irdelemeyi amaçladık. Yöntemler: Esansiyel hipertansiyonu olan 80 hasta çalışmaya alındı. Spot idrarda mikroalmüminüri bakıldı, açlık kanında insülin glukoz ölçülerek HOMA-IR ile insülin direnci hesaplandı ve RI değerinin tespiti için renal doppler untrosonografi yapıldı. Mikroalbuminürisi olan ve olmayan, insü- lin direnci olan ve olmayan hastaların RI değerleri karşılaştırdı, ayrıca yaş ve cinsiyetin de RI değerine olan etkilerine bakıldı. Bulgular: Hastaların 42'si kadın 38'i erkekti. Yaş ortalamaları 51,9±9,5 olup hastaların 49'unun yaşı 50'nin üzerinde idi. Hastaların 32'inde mikroalbuminüri tespit edildi. Mikroalbumnürisi olanların 17'sinin yaşı 50'den büyüktü. Yedi hastada RI yüksek bulundu ve bu hastaların yaşları 50'nin üzerinde idi. Mikroalbuminüri ile RI arasında anlamlı bir korelasyon gözlenmedi. Sonuç: RI değerinin ileri yaşta daha yüksek olduğu ancak cinsiyet, mikroalbuminüri ve insülin direnci ile RI arasında anlamlı bir ilişki olmadığı görüldü.

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Cite This Article

BARUT, Y., ALTUNOĞLU, E. G., ÖZBAŞ, N., RAKICI, İ. T. (2022). The Relationship between Microalbuminuria, Insulin Resistance and Renal Blood Flow in Patients with Primary Hypertension. İstanbul Medical Journal, Cilt: 14 - Sayı: 4, 266–270. https://ajindex.com/articles/552290

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