Journals / İstanbul Medical Journal / 2015 / Cilt: 16 - Sayı: 1

Effect of Embryo Transfer on Days 2 and 3 on Pregrancy Rates in Patients Undergoing Controlled Ovarian Hyperstimulation / Intracytoplasmic Sperm Injection

Kontrollü Ovarian Hiperstimülasyon / İntrastoplazmik Sperm İnjeksiyonu Yapılan Hastalarda 2 ve 3. Gün Embriyo Transferlerinin Gebelik Oranlarına Etkisi

Pages
1–4
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Embryo transfer may be performed either on day 2 or 3 according to the work program of the clinic.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study is to investigate the effect of embryo transfer of days 2 and 3 on pregnancy rates in patients undergoing controlled ovarian hyperstimulation/ intracytoplasmic sperm injection.
📊
Key Findings & Data:Methods: Individuals admitted to our clinic due to of male factor infertility between February 2006 and May 2010 and who underwent ICSI with the antagonist protocol were included in this study.
💡
Conclusion & Impact:Embryo transfer may be performed either on day 2 or 3 according to the work program of the clinic.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to investigate the effect of embryo transfer of days 2 and 3 on pregnancy rates in patients undergoing controlled ovarian hyperstimulation/ intracytoplasmic sperm injection. Methods: Individuals admitted to our clinic due to of male factor infertility between February 2006 and May 2010 and who underwent ICSI with the antagonist protocol were included in this study. Pregnancy rates between days 2 and 3 after embryo transfer were compared. Results: Embryo qualities were similar between groups (p=0,828). Although pregnancy rates tended to be higher in the 2-day transfer group, it was not statistically significant (p=0,18). Azoospermia and the number of retrieved oocytes were predictive factors for a favorable outcome (p=0,001). Conclusion: Retaining the embryos in culture for 3 days had no negative influence on pregnancy outcomes. Embryo transfer may be performed either on day 2 or 3 according to the work program of the clinic.

Özet

Amaç: Bu çalışmanın amacı kontrollü ovarian hiperstimülasyon (KOH)+ İntrasitoplazmik sperm injeksiyonu (İCSİ) uygulanan hastalarda 2 ve 3. gün embriyo transferinin (ET) gebelik oranlarına etkisinin araştırılması. Yöntemler: Kliniğimize Şubat 2006 ile Mayıs 2010 tarihleri arasında erkek faktörü nedeniyle başvuran ve antagonist protokol ile İCSİ uygulanan hastalar çalışmaya alındı. İkinci ve 3. gün ET yapılan hasta gruplarının gebelik oranları karşılaştırıldı. Bulgular: İkinci ve 3. gün transfer yapılan hasta gruplarında embriyo kaliteleri benzerdi (p=0,828). İkinci gün transfer yapılan grupta gebelik oranları daha yüksek olmasına rağmen istatistiki olarak anlamlı bir fark saptanmadı (p=0,18). Gebe kalmaya etki eden faktörler azoospermi (p=0,02) ve toplanan oosit sayısı (-p=0,001) olarak bulundu. Sonuç: Embriyoların kültürde 3 gün bekletilmesinin gebelik sonuçları üzerine olumsuz bir etkisi yoktur. ET kliniğin çalışma programına ve hastanın durumuna göre 2. veya 3. gün yapılabilir.

🔖

Cite This Article

ÇELİK, S., GÜRBÜZ, B., PURİSA, S., ÇELİK, D. C. (2022). Effect of Embryo Transfer on Days 2 and 3 on Pregrancy Rates in Patients Undergoing Controlled Ovarian Hyperstimulation / Intracytoplasmic Sperm Injection. İstanbul Medical Journal, Cilt: 16 - Sayı: 1, 1–4. https://ajindex.com/articles/552169

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (2)

  1. Edwards RG, Steptoe PC, Purdy JM. Establishing full-term human pregnancies using cleaving embriyos grown in vitro. Br J Obstet Gyne- col 1980; 87: 737-56. [CrossRef] Gardner DK, Vella P, Lane M, Wagley T, Schlenker T, Schoolcraft WB. Culture and transfer of human blastocyst increases implantation ra- tes and reduces the need for multiple embriyo transfer. Fertil Steril 1998; 69: 84-8. [CrossRef] Källén B, Finnström O, Lindam A, Nilsson E, Nygren KG, Olausson PO. Blastocyst versus cleavage stage transfer in in vitro fertilization: diffe- rences in neonataloutcome? Fertil Steril 2010; 94: 1680-3. [CrossRef] Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embriyo transfer in assisted reproductive technology. Cochrane Database Syst Rev 2012; 7: CD002118. [CrossRef] Braude P, Bolton V, Moore S. Human gene expression first occurs bet- ween the four and eight cell stages of preimplantation development. Nature 1988; 332: 458-61. [CrossRef] Ertzeid G, Dale PO, Tanbo T, Storeng R, Kjekshus E, Abyholm T. Clini- cal outcome of day 2 versus day 3 embriyo transfer using serum-free culture media: A prospective randomized study. J Assist Reprod Genet 1999; 16: 529-34. [CrossRef] Oatway C, Gunby J, Daya S. Day three versus day two embriyo transfer following in vitro fertilization or intracytoplasmic sperm injection. Cochrane Database Syst Rev 2004; 2: CD004378. Dawson KJ, Conaghan J, Ostera GR, Winston ML R, Hardy K. Delaying transfer to the third post-insemination, to select non-arrested emb- riyos, increases development to the fetal heart stage. Hum Reprod 1995; 10: 177-82. [CrossRef] Ashrafi M, Kiani K, Mirzaagha E, Shabani F.The Pregnancy Outcomes of Day 2 versus Day 3 Embriyo Transfer: A Cross-Sectional Study. Irani- an Journal of Fertility and Sterility 2007; 1(2): 47-54.
  2. Hardarson T, Hanson C, Sjögren A, Lundin K. Human embriyos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation. Hum Reprod 2001; 16: 313-8. [CrossRef] Urman B, Yakin K, Ata B, Isiklar A, Balaban B. Effect of hyaluronan- enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embriyo transfers: a prospective randomized study. Fertil Steril 2008; 90: 604-12. [CrossRef] Edwards RG, Fishel SB, Cohen J, Fehilly CB, Purdy JM, Slater JM, Steptoe PC, Webster JM. Factors influencing the success of in vitro fertilizati- on for alleviating human infertility. J In Vitro Fertil.