Journals / The Anatolian Journal of Cardiology / 2022 / Cilt: 26 - Sayı: 1

Kounis syndrome associated with BNT162b2 mRNA COVID-19 vaccine presenting as ST-elevation acute myocardial infarction

Pages
72–74
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This syndrome has been reported with different SARS-CoV-2 vaccines (4, 5); and to the best of our knowledge, we present the first Kounis syndrome after an mRNA vaccine.

📌 3 Key Takeaways

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Objective & Hypothesis:Vaccination is considered the key process of immunization against the ongoing pandemic.
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Key Findings & Data:Because of the accelerating vaccination efforts worldwide, the possibility of rare adverse effects happening has increased.
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Conclusion & Impact:This syndrome has been reported with different SARS-CoV-2 vaccines (4, 5); and to the best of our knowledge, we present the first Kounis syndrome after an mRNA vaccine.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Vaccination is considered the key process of immunization against the ongoing pandemic. The mass vaccination process has started with different vaccine types, varying globally. Because of the accelerating vaccination efforts worldwide, the possibility of rare adverse effects happening has increased. Over 100 million COVID-19 vaccine doses has been administrated in Turkey (1). Although it is known that the adverse effects of COVID-19 vaccines have low incidence (2), allergic side effects are possible similar to any other medication. Although a wide spectrum of symptoms can be seen, from mild allergic complaints to angioedema, Kounis syndrome is one with undesirable effects. Hypersensitivity coronary disorder was originally described in 1991 by Kounis as acute coronary syndrome associated with an allergic reaction (3). This syndrome has been reported with different SARS-CoV-2 vaccines (4, 5); and to the best of our knowledge, we present the first Kounis syndrome after an mRNA vaccine.

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Cite This Article

ŞANCI, E., ÖZEN, M. T., ÇELİK, O. M., BOZYEL, S., ÖRÇEN, C. (2022). Kounis syndrome associated with BNT162b2 mRNA COVID-19 vaccine presenting as ST-elevation acute myocardial infarction. The Anatolian Journal of Cardiology, Cilt: 26 - Sayı: 1, 72–74. https://ajindex.com/articles/407469

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References (3)

  1. Ministry of Health, Turkey. COVID-19 Vaccination information platform [accessed 13 September 2021]. Available from: URL:
  2. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al.; C4591001 Clinical Trial Group. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med 2020; 383: 2603-15. [Crossref] 3. Kounis NG, Zavras GM. Histamine-induced coronary artery spasm: the concept of allergic angina. Br J Clin Pract 1991; 45: 121-8
  3. Özdemir İH, Özlek B, Özen MB, Gündüz R, Bayturan Ö. Type 1 Kounis Syndrome Induced by Inactivated SARS-COV-2 Vaccine. J Emerg Med 2021; 61: e71-6. [Crossref] 5. Maadarani O, Bitar Z, Elzoueiry M, Nader M, Abdelfatah M, Zaalouk T, et al. Myocardial infarction post COVID-19 vaccine - coincidence, Kounis syndrome or other explanation - time will tell. JRSM Open 2021; 12: 20542704211025259. [Crossref] 6. Boivin Z, Martin J. Untimely Myocardial Infarction or COVID-19 Vaccine Side Effect. Cureus 2021; 13: e13651. [Crossref] 7. Kounis NG. Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm? Int J Cardiol 2006; 110: 7-14. [Crossref] 8. Kounis NG. Coronary hypersensitivity disorder: the Kounis syndrome. Clin Ther 2013; 35: 563-71. [Crossref]