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Journals / İstanbul Medical Journal / 2021 / Cilt: 22 - Sayı: 4

Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

Kür Sağlanan Hodgkin Lenfoma Hastalarının Uzun Dönem Takibinde Sol Ventrikül Fonksiyonlarının İki Boyutlu Strain Ekokardiyografi ile Değerlendirilmesi

Meliha NALÇACI
Adem ATICI
Pelin KARACA ÖZER
Berrin UMMAN
Mustafa ALTINKAYNAK
Rafet BAŞAR
Nida ÖZTOP
Pages
300–305
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up.
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Key Findings & Data:Methods: This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or withoutmediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers.
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Conclusion & Impact:The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up. Methods: This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or withoutmediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers. To assess long-term cardiac complications, we performed 12-lead electrocardiography and 2D transthoracic echocardiography. In addition to conventional echocardiographic parameters, we used tissue Doppler echocardiography for LV diastolic functions and 2D-STE for evaluating the global longitudinal strain (GLS) of the LV myocardium. Results: The mean age of the HL survivors was 40±15 years and the female sex was predominant (11/21). The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p

Özet

Amaç: İki boyutlu strain ekokardiyografi (2D-STE) sol ventrikül (SV) sistolik fonksiyonlarının ölçümünde hassas bir ölçüm yöntemidir. Hodgkin lenfoma (HL) hastalarının takibinde ortaya çıkabilecek geç kardiyak yan etkilerin değerlendirilmesinde kullanılabilir. Yöntemler: Bu çalışma antrasiklin (n=21) ± mediasten (8/21)/ mediasten dışı (8/21) ışın tedavisi alan, en az 3 yıl takipte nüks saptanmamış 21 HL hastası ve yaşları eşleştirilmiş 43 sağlıklı bireyin karşılaştırıldığı kesitsel çalışmadır. Bireylerin kardiyak komplikasyonları 12 derivasyonlu elektrokardiyografi ve konvansiyonel ekokardiyografi ile değerlendirildi. SV diyastolik fonksiyonu için doku Doppler ekokardiyografi, SV miyokardiyumun global longitudinal strain (GLS) değerlendirmesi için 2D-STE kullanıldı. Bulgular: HL hastalarının ortalama yaşı 40±15 saptandı ve çoğunlukla kadındı (11/21). HL hastalarında kontrol grubuna göre ortalama PR mesafesi anlamlı derecede artmış (154,7±19,6 ms vs 133,8±13,9 ms, p

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Cite This Article

NALÇACI, M., ATICI, A., ÖZER, P. K., UMMAN, B., ALTINKAYNAK, M., BAŞAR, R., ÖZTOP, N. (2022). Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up. İstanbul Medical Journal, Cilt: 22 - Sayı: 4, 300–305. https://ajindex.com/articles/551816

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References (13)

  1. RS S. Hodgkin’s disease. In: Lee RG, Foerster J, Lukens J (eds). Wintrobe’s Clinical Hematology. Egypt, Mass Pub; 1999; p. 2538-71
  2. Boyd A, Stoodley P, Richards D, Hui R, Harnett P, Vo K, et al. Anthracyclines induce early changes in left ventricular systolic and diastolic function: A single center study. PLoS One 2017; 12: e0175544
  3. Smiseth OA, Torp H, Opdahl A, Haugaa KH, Urheim S. Myocardial strain imaging: how useful is it in clinical decision making? Eur Heart J 2016; 37: 1196-207
  4. Kang Y, Cheng L, Li L, Chen H, Sun M, Wei Z, et al. Early detection of anthracycline-induced cardiotoxicity using two-dimensional speckle tracking echocardiography. Cardiol J 2013; 20: 592-9
  5. Hodges M. Bazett’s QT correction reviewed: evidence that a linear QT correction for heart rate is better. J Am Coll Cardiol 1983; 1: 694
  6. Nagueh SF, Smiseth OA, Appleton CP, Byrd BF, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Echocardiogr 2016; 17: 1321-60
  7. Yingchoncharoen T, Agarwal S, Popović ZB, Marwick TH. Normal ranges of left ventricular strain: a meta-analysis. J Am Soc Echocardiogr 2013; 26: 185-91
  8. Lipshultz SE, Landy DC, Lopez-Mitnik G, Lipsitz SR, Hinkle AS, Constine LS, et al. Cardiovascular status of childhood cancer survivors exposed and unexposed to cardiotoxic therapy. J Clin Oncol 2012; 30: 1050-7
  9. Benetou DR, Stergianos E, Geropeppa M, Ntinopoulou E, Tzanni M, Pourtsidis A, et al. Late-onset cardiomyopathy among survivors of childhood lymphoma treated with anthracyclines: a systematic review. Hellenic J Cardiol 2019; 60: 152-64
  10. Feijen EA, Leisenring WM, Stratton KL, Ness KK, van der Pal HJ, van Dalen EC, et al. Derivation of anthracycline and anthraquinone equivalence ratios to doxorubicin for late-onset cardiotoxicity. JAMA Oncol 2019; 5: 864-71
  11. Coccia PF, Altman J, Bhatia S, Borinstein SC, Flynn J, George S, et al. Adolescent and young adult oncology. J Natl Compr Canc Netw 2012; 10: 1112-50
  12. Morandi P, Ruffini P, Benvenuto G, La Vecchia L, Mezzena G, Raimondi R. Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m(2)) cyclophosphamide. Bone Marrow Transplant 2001; 28: 277-82
  13. Kishi S, Yoshida A, Yamauchi T, Tsutani H, Lee J, Nakamura T, et al. Torsade de point