Journals / İstanbul Medical Journal / 2021 / Cilt: 22 - Sayı: 2

The Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosis

İntravenöz Tromboliz ile Tedavi Edilen İskemik İnme Hastalarında Platelet/Lenfosit Oranının Mortalite, Disabilite ve Prognoz ile İlişkisi

Pages
161–167
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The lymphocyte count was low and the PLR was highin patients with a high level of initial disability (p

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The platelet/lymphocyte ratio (PLR) has beenstudied frequently to determine the prognosis of cardiovasculardiseases, chronic inflammatory diseases, and malignancies.Particularly, the PLR is an indicator of systemic inflammationand atherosclerosis.
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Key Findings & Data:At the 24th and 72nd hours aftertreatment, hemorrhagic transformation was evaluated bybrain computed tomography.
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Conclusion & Impact:The lymphocyte count was low and the PLR was highin patients with a high level of initial disability (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The platelet/lymphocyte ratio (PLR) has beenstudied frequently to determine the prognosis of cardiovasculardiseases, chronic inflammatory diseases, and malignancies.Particularly, the PLR is an indicator of systemic inflammationand atherosclerosis. In this study, we aimed to evaluate thevalue of the PLR and its relationship with mortality, cerebralhemorrhagic transformation, and short-term prognosis inpatients with stroke treated with intravenous thrombolysis.Methods: Two hundred fifty stroke patients treated withintravenous thrombolysis were included in the study. Initialsymptoms, comorbidities, and localization of cerebral ischemiawere recorded. Disability was scored on the National Institutesof Health (NIH) stroke scale. At the 24th and 72nd hours aftertreatment, hemorrhagic transformation was evaluated bybrain computed tomography. The in-hospital mortality ratewas calculated. Patients were divided into groups accordingto the difference in the NIH stroke scale (between admissionand discharge). Serum platelet and lymphocyte levels and PLRvalues were determined.Results: There were 128 (51.2%) female and 122 (48.8%) malepatients included in the study. Their mean age was 71.88±12.36years. The lymphocyte count was low and the PLR was highin patients with a high level of initial disability (p

Özet

Amaç: Platelet/lenfosit oranı (PLO) kardiyovasküler hastalıkların, kronik enflamatuvar hastalıkların ve malignitelerin prognozunu belirlemek için sıklıkla çalışılmıştır. PLO özellikle sistemik enflamasyonun ve aterosklerozun bir göstergesidir. Bu çalışmada, intravenöz tromboliz uygulanan inme hastalarında PLO değerinin mortalite, serebral hemorajik transformasyon ve kısa dönem prognoz ile ilişkisini değerlendirmeyi amaçladık. Yöntemler: Çalışmaya intravenöz tromboliz ile tedavi edilmiş 250 inme hastası alındı. Başvuru semptomu, ek hastalıkları ve serebral iskemi lokalizasyonu kaydedildi. Disabilite Ulusal Sağlık Enstitüleri (NIH) inme skalası ile hesaplandı. Tedavi sonrası 24. ve 72. saatlerde beyin bilgisayarlı tomografi ile hemorajik transformasyon değerlendirildi. Hastane içi mortalite oranı hesaplandı. Hastalar başvuru ve taburculuk arası NIH inme skalası sonucu farkına göre gruplara ayrıldı. Serum trombosit, lenfosit seviyesi ve PLO değerleri belirlendi. Bulgular: Çalışmada 128 (%51,2) kadın ve 122 (%48,8) erkek hasta vardı. Yaş ortalamaları 71,88±12,36 idi. Başvuru disabilitesi yüksek hastalarda lenfosit sayısı düşük, PLO yüksekti (p

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Cite This Article

EREN, F., DEMİR, A., EREN, G. (2022). The Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosis. İstanbul Medical Journal, Cilt: 22 - Sayı: 2, 161–167. https://ajindex.com/articles/551815

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