The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
📌 3 Key Takeaways
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Objective & Hypothesis:Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD.
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Key Findings & Data:SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms.
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Conclusion & Impact:The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
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Cite This Article
AŞKIN, L., TANRIVERDİ, O., TİBİLLİ, H., TÜRKMEN, S. (2022). The relationship between coronary artery diseaseand SIRT1 protein. İstanbul Kuzey Klinikleri, Cilt: 7 - Sayı: 6, 631–635. https://ajindex.com/articles/551417
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