AI Summary & Key Takeaways
AI InsightConclusion: NT-proBNP levels are not related with IL6 levels and thioredoxin reductase in patients on dialysis
📌 3 Key Takeaways
Abstract
Aim: Cytokines have a direct stimulating effect on natriuretic peptide secretion. N-terminal probrain type natriuretic peptide (NT-proBNP) is a valuable biomarker for mortality in dialysis patients. The aim of this study was to compare thioredoxin reductase, NT-proBNP, IL6 levels and high sensitive C reactive protein (HsCRP) in peritoneal dialysis (PD), and hemodialysis (HD) patients and investigate relationship among these parameters. Material and Methods:In age and sex matched 30 HD patients, in 30 PD patients and 20 healthy controls, HsCRP, thioredoxin reductase, serum IL6, and NT-proBNP levels were measured. Results: HsCRP, IL6 and NT-proBNP levels in HD and PD patients were significantly higher than in controls (p0.05). Thioredoxin reductase was not different in 3 groups (p>0.05). Thioredoxin reductase was not correlated with any studiedparameters. HsCRP levels were positively correlated with BMI (r:0.275, p:0.034), IL6 (r:0.633, p:0.000), and NT-proBNP (r:0.277, p:0.032), and negatively correlated with serum albumin levels (r:-0.425, p:0.001). Serum IL6 levels were positively correlated with HsCRP (r:0. 633 p:0.000), BMI (r:0.775, p:0.034) and negatively correlated with albumin (r:-0.342, p:0.007). Serum NT-proBNP levels were negatively correlated with serum albumin (r:-0.385, p:0.002), and positively correlated with age (r:0.315, p:0.002), HsCRP (r:0.277, p:0.032), systolic (r:0.421, p:0.001) and mean blood pressure (r:0.311, p:0.015). In multiple regression analyses the predictors of HsCRP were IL6 (?:0.677, p:0.000), the predictor of serum IL6 was HsCRP (?:0.677, p:0.000). The predictors of serum NT-proBNP levels were serum albumin (?:-0.416, p:0.000) and mean blood pressure (?:0.414, p:0.000). Conclusion: NT-proBNP levels are not related with IL6 levels and thioredoxin reductase in patients on dialysis
Özet
Amaç: Sitokinler natriüretik petid sekresyonunda direk uyarıcı etkiye sahiptir. N terminal probeyin tip natriüretik peptid diyaliz hatalarının mortalitesinde önemli bir biyobelirteçtir. Bu çalışmanın amacı peritonel diyaliz(PD) ve hemodiyaliz(HD) hastalarında; tiyoredoksin redüktaz aktivitesi ile NT-proBNP, IL6 ve yüksek duyarlıklı C reaktif protein seviyelerini (HsCRP)karşılaştırmak ve aralarındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Yaş ve cinsiyet değişkenlerine gore 30 HD, 30 PD ve 20 kontrol sağlıklı denek gruplara ayrılarak HsCRP, serum IL6, NT-proBNP seviyeleri ile tiyoredoksin redüktaz aktivitesi ölçüldü. Sonuç: HsCRP, serum IL6, NT-proBNP seviyeleri HD ve PD hastalarında kontrol grubuna kıyasla istatiksel olarak anlamlı derecede yüksek bulundu (p0,05), tiyoredoksin redüktaz aktivitesi 3 grupta da fark göstermedi. Ayrıca tiyoredoksin redüktaz aktivitesi çalışmadaki hiçbir parametre ile korelasyon göstermedi. HsCRP; BMI(r:0.275, p:0.034), IL6 (r:0.633, p:0.000), NT proBNP (r:0.277, p:0.032) ile pozitif korelasyon gösterirken, serum albumin konsantrasyonu ile negative korelasyon (r:-0.425, p:0.001) gösterdi. Serum IL6 seviyeleri HsCRP (r:0.633, p:0.000) ve BMI (r:0.775, p:0.034) ile pozitif, albumin ile negative (r:-0.342, p:0.007) korelasyon gösterdi. Serum NT-proBNP seviyeleri ise serum albumini ile negatif; yaş (r:0.315, p:0.002), HsCRP (r:0.277, p:0.032), sistolik (r:0.421, p:0.001) ve ortalama kan basıncı ile (r:0.311, p:0.015) ise pozitif korelasyon gösterdi.