Hemolytic Uremic Syndrome as a Cause of Adult Acute Renal Failure

In this case report, the clinical features,diagnosis, pathophysiology, and treatment of an adult with acute renal failure due to thethrombotic microangiopathy with hemolytic uremic syndrome are discussed

📌 3 Key Takeaways

🎯

Objective & Hypothesis:Thrombotic microangiopathy is a microvascular occlusive disorder characterized bymicroangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organinjury due to platelet thrombosis in the microcirculation.

📊

Key Findings & Data:Regarding to the severe ofbrain or renal lesions, two clinical entities (pathologically similar but clinically different)are described: thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.Thrombotic thrombocytopenic purpura usually affect adults, and is characterized bysevere neurologic involvement in most cases, and variable renal involvement.

💡

Conclusion & Impact:In this case report, the clinical features,diagnosis, pathophysiology, and treatment of an adult with acute renal failure due to thethrombotic microangiopathy with hemolytic uremic syndrome are discussed

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Thrombotic microangiopathy is a microvascular occlusive disorder characterized bymicroangiopathic hemolytic anemia, thrombocytopenia, and variable signs of organinjury due to platelet thrombosis in the microcirculation. Regarding to the severe ofbrain or renal lesions, two clinical entities (pathologically similar but clinically different)are described: thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.Thrombotic thrombocytopenic purpura usually affect adults, and is characterized bysevere neurologic involvement in most cases, and variable renal involvement. Hemolyticuremic syndrome occurs in young children, and is characterized by acute renal failure,and absent or minimal neurologic abnormalities. In this case report, the clinical features,diagnosis, pathophysiology, and treatment of an adult with acute renal failure due to thethrombotic microangiopathy with hemolytic uremic syndrome are discussed

Özet

Trombotik mikroanjiopati, mikroanjiopatik hemolitik anemi, trombositopeni ve çeşitli organ tutulumları ile karekterize mikrovasküler bir hastalıktır. Trombotik mikroanjiopati’de beyin veya böbrek tutulumunun ciddiyetine göre; patolojik olarak benzer, ancak klinik olarak farklı iki klinik tablo tarif edilmiş olup; bunlar trombotik trombositopenik purpura ve hemolitik üremik sendrom olarak adlandırılmıştır. Trombotik trombositopenik purpura daha çok erişkinlerde görülmektedir, nörolojik bulgular ön plandadır ve böbrek tutulumu hafiftir. Buna karşın hemolitik üremik sendrom, daha çok çocukluk çağında görülür, akut böbrek yetmezliği belirleyici özellik olup, nörolojik bulgular hafif veya yoktur. Bu olgu sunumunda erişkin akut böbrek yetmezliği gelişen trombotik mikroanjiopatiye bağlı hemolitik üremik sendromun klinik bulguları, tanısı, patofizyolojisi ve tedavisi tartışılmıştır.

🔖

Cite This Article

Yücel, N., Gedik, E., Toğal, T., Karahan, K., Şahin, T., Koca, E. (2022). Hemolytic Uremic Syndrome as a Cause of Adult Acute Renal Failure. İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi, Cilt: 23 - Sayı: 1, 120–122. https://ajindex.com/articles/549183

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (15)

Amorosi EL, Ultmann JE. Thrombotic thrombocytopenic purpura: report of 16 cases and review ofthe literature. Medicine 1966;45:139-59
Halevy D, Radhakrishan J, Markowitz G, et al. Thrombotic microangiopathies. Crit Care Clin 2002;18:309-20
Akoğlu E, Paydaş S, Sezer T, Böbreğin vasküler hastalıkları. In: İliçin G, Ünal S, Biberoğlu K, Akalın S, Süleymanlar G (eds), Temel İç Hastalıkları, Ankara: Güneş Yayınevi; 1996. p. 855-8
Siegler RL. The Hemolytic Uremic Syndrome. Pediatr Clin North Am 1995;42(6):1505-29
Rock GA, Shumak KH, Buskard NA, et al. Comparison of plasma exchange with plasma infusionin the treatment of thrombotic thrombocytopenic purpura. N Engl J Med 1991;325:93-397
Rock G, Shumak K, Kelton J, et al. Thromboticthrombocytopenic purpura: outcome in 24 patients with renal impairment treated with plasma exchange. Transfusion 1992;32:710-4
Palermo MS, Exeni RA, Fernández GC. Hemolytic uremic syndrome: pathogenesis and update of interventions. Expert Rev Anti Infect Ther 2009;7(6):697- 707
Hollenbeck M, Kutkuhn B, Aul C, Leschke M, Willers M, Grabensee B. Haemolytic-uremic syndrome and thrombotic-thrombocytopenic purpura in adults: clinical findings and prognosis factors for death and end-stage renal dsease. Nephrol Dial Transplant 1998;13:76–81
Schieppati A, Ruggenenti P, Plata Cornejo R et al. for the Italian Registry of Haemolytic Uremic Syndrome. Renal function at hospital admission as a prognosis factor in adult hemolytic uremic syndrome. J Am Soc Nephrol 1992;2:1640-4
French Cooperative Study Group for HUS. Adult hemolytic uremic syndrome with renal microangiopathy. Outcome according to therapeutic protocol in 53 cases. Ann Med Intern 1992;143 [Suppl. 1]:27–32
Garg AX, Suri RS, Barrowman N, Rehman F, Matsell D,Rosas-Arellano MP, Salvadori M, Haynes RB, Clark WF, Long-term renal prognosis of diarrhea-associated hemolyticuremic syndrome: A systematic review and meta-analysis. JAMA 2003, 290:1360–70
Mead PS, Griffin PM: Escherichia coli O157:H7. Lancet 1998;352:1207-12
Milford D: The hemolytic uremic syndromes in the UK. In: Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura, ed. Kaplan BS, Trompeter RS, Moake JL, New York, Marcel Dekker, 1992;39-59
Lara PN Jr, Coe TL, Zhou H, Fernando L, Holland PV, Wu T. Improved survival with plasma exchange in patients with thrombotic thrombocytopenic purpurahemolytic uremic syndrome. Am J Med 1999;10786:573-9
Gerth J, Busch m, Ott