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Journals / İnönü Üniversitesi Tıp Fakültesi Dergisi / 2008 / Cilt: 15 - Sayı: 4

Corelation between preoperative serum CEA, CA19-9, and AFP levels and clinicopathologic factors

Mide kanserlerinde preoperatif serum CEA, CA19-9 ve AFP düzeylerinin klinikopatolojik faktörlerle korelasyonu

Burak IŞIK
Fatih SÜMER
Cüneyt KAYAALP
İlhan ASLAN
Abuzer DİRİCAN
Bülent ÜNAL
Pages
233–237
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To investigate the correlation between preoperative serums CEA, CA19-9, and alpha-fetoprotein (AFP) levels and clinic pathological factors.
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Key Findings & Data:Methods: The correlation between the records of pre-operative serum CEA, CA19-9, and alpha-fetoprotein levels and some clinic-pathological factors (tumor stage, liver metastasis, peritoneal metastasis, presence of ascites, unresectable tumors) of 74 patients with gastric adenocarcinoma operated in Ankara Yildirim Beyazit Education and Training Hospital 2nd Surgery Clinic was investigated.
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Conclusion & Impact:Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To investigate the correlation between preoperative serums CEA, CA19-9, and alpha-fetoprotein (AFP) levels and clinic pathological factors. Methods: The correlation between the records of pre-operative serum CEA, CA19-9, and alpha-fetoprotein levels and some clinic-pathological factors (tumor stage, liver metastasis, peritoneal metastasis, presence of ascites, unresectable tumors) of 74 patients with gastric adenocarcinoma operated in Ankara Yildirim Beyazit Education and Training Hospital 2nd Surgery Clinic was investigated. Results: Preoperative elevated serum CEA, CA19-9, and alpha-fetoprotein levels were found 31.4%, 30.3, and 16.4, respectively. While 31 (41.8%) out of 74 patients had one or more positive tumor markers, all three markers-were found to be high in 8 patients (13.1%). Six of these patients were in stage 4, and the other two patients were in stage 3. Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma.

Özet

Amaç: Gastrik adenokarsinomlu hastalarda preoperatif serum karsinoemriyonik antijen (CEA), CA19-9 ve alfa-rfetoprotein (AFP) düzeyi ile klinikopatolojik faktörlerin korelasyonunu araştırmak. Metot: Gastrik adenokarsinom sebebiyle Ankara Yıldırım Beyazıt Eğitim Hastanesi 2. Cerrahi Kliniğinde ameliyat edilen 74 hastanın kayıtları retrospektif olarak incelendi. Hastaların preoperatif serum CEA, ÇA19-9, AFP düzeyleri ile bazı klinikopatolojik faktörler (tümör evresi, karaciğer metastazı, peritoneal metastaz, asit varlığı, tümörün rezeke edilebilirliği) arasındaki korelasyon araştırıldı. Bulgular: Hastaların preoperatif serum CEA, CA19-9, AFP pozitiflik oranlan sırası ile %31.4, 30.3 ve 16.4 olarak bulundu. Hastaların 31'inde (%41,8) bir veya birden fazla tümör markın yüksek iken, 8'inde(%13.1) üç markır da yüksek bulundu. Bu 8 hastanın 6'sı evre 4, 2'si evre 3 teki hastalardı. Sonuç: Gastrik adenokarsinomlu hastalarda preoperatif serum CEA, CA19-9, AFP seviyelerinin ileri evreli, karaciğer metastazı yapmış, rezektabıl olmayan tümörlerde anlamlı oranda yüksek olduğu görüldü.

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Cite This Article

IŞIK, B., SÜMER, F., KAYAALP, C., ASLAN, İ., DİRİCAN, A., ÜNAL, B. (2022). Corelation between preoperative serum CEA, CA19-9, and AFP levels and clinicopathologic factors. İnönü Üniversitesi Tıp Fakültesi Dergisi, Cilt: 15 - Sayı: 4, 233–237. https://ajindex.com/articles/548618

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