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Journals / İnönü Üniversitesi Tıp Fakültesi Dergisi / 2012 / Cilt: 19 - Sayı: 2

Assessment of Endothelium-dependent and independent vasodilation of brachial artery in polycystic ovary syndrome

Polikistik over sendromunda, brakiyal arter'in Endotel bağımlı ve bağımsız vazodilatasyonun araştırılması

Murat BAYKARA
Cumali GÖKÇE
Pages
82–87
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Endothelium dependent dilation in PCOS patients (7.8±5.4%) was significantly (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The endothelium plays an important role in the regulation of vascular tone.
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Key Findings & Data:A decreased distensibility is an important risk factor for cardiovascular disease.
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Conclusion & Impact:Endothelium dependent dilation in PCOS patients (7.8±5.4%) was significantly (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The endothelium plays an important role in the regulation of vascular tone. Arterial distensibility is a marker of functional and structural wall properties. A decreased distensibility is an important risk factor for cardiovascular disease. Hyperandrogenism may be related to impaired systemic arterial vascular compliance. In this study, using a non-invasive ultrasonography method, we investigated endothelium dependent and endothelium independent vasodilation in the brachial artery of the patients with polycystic ovary syndrome (PCOS). Materials and Methods: Fourteen hyperandrogenemic patients with PCOS and 18 healthy age and BMI matched controls were included in the study. Serum DHEAS, androstenedione, total and free testosterone levels were measured for the diagnosis of hyperandrogenism. Brachial artery diameter was measured at baseline, during postocclusion reactive hyperaemia (flow-mediated, endothelium dependent dilation), and after 400 μg glyceryl trinitrate sublingually (endothelium-independent dilation). Vasodilation was expressed as the percentage change relative to the baseline diameter. Results: Baseline flow and blood pressure were similar in the patients with PCOS and healthy subjects. Baseline vessel diameter (mm) was not statistically different between the patients with PCOS (3.2±0.3) and control group (3.1±0.4). Endothelium dependent dilation in PCOS patients (7.8±5.4%) was significantly (p

Özet

Amaç: Endotel vasküler tonusun düzenlenmesinde önemli bir rol oynar. Arteryel esneklik fonksiyonel ve yapısal duvar özelliklerinin bir göstergesidir. Azalmış esneklik kardiyovasküler hastalıklar için önemli bir risk faktörüdür. Hiperandrojenizm sistemik arteryel kompliyans bozukluğu ile ilgili olabilir. Bu çalışmada, non invaziv ultrasonografi yöntemi kullanarak polikistik over sendromlu (PKOS) kadınlarda brakiyal arterde endotel bağımlı ve endotel bağımsız vazodilatasyonu araştırdık. Gereç ve Yöntem: Ondört PKOS’lu hiperandrojenemik kadın ile yaş ve vücut kitle indeksi uyumlu 18 olguluk sağlıklı kontrol grubu çalışmaya alındı. Hiperandrojenizm tanısı için serum DHEAS, androstenedion, total ve serbest testosteron düzeyleri ölçüldü. Brakiyal arter çapı başlangıçta, tıkanık sonrası reaktif hiperemi (akım aracılı, endotel bağımlı dilatasyon) ile dilaltı 400 mikrogram gliseril trinitrat sonrasında (endotel bağımsız dilatasyon) ölçüldü. Vazodilatasyon başlangıç çapına göreceli olarak yüzde değişim olarak ifade edildi. Bulgular: Başlangıç akımı ve kan basıncı PKOS’lu kadınlarda ve sağlıklı kontrollerde benzerdi. Başlangıç damar çapı (mm) PKOS’lu kadınlarla (3,2±0,3) kontrol grubu (3,1±0,4) arasında istatistiksel olarak farklı değildi. Akım aracılı dilatasyon PKOS’lu kadınlarda (%7,8±5,4) kontrol grubuna (%14,9±7,9) göre anlamlı olarak (p

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Cite This Article

BAYKARA, M., GÖKÇE, C. (2022). Assessment of Endothelium-dependent and independent vasodilation of brachial artery in polycystic ovary syndrome. İnönü Üniversitesi Tıp Fakültesi Dergisi, Cilt: 19 - Sayı: 2, 82–87. https://ajindex.com/articles/548446

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