SavedAdd your journal

Journals / International Journal of Secondary Metabolite / 2017 / Cilt: 4 - Sayı: 3

Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro

Muhammed ALTUN
Fatih GUL
Ramazan ERENLER
Ibrahim DEMIRTAS
Tunay KARAN
Pages
512–516
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects.
📊
Key Findings & Data:Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate.
💡
Conclusion & Impact:Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kickxia spuria · flavone · HeLa

Abstract

Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.

Özet

Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.

🔖

Cite This Article

ALTUN, M., GUL, F., ERENLER, R., DEMIRTAS, I., KARAN, T. (2022). Inhibitory Effect of 6,7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro. International Journal of Secondary Metabolite, Cilt: 4 - Sayı: 3, 512–516. https://ajindex.com/articles/541756

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Jhanwar, Y.S., & Divgi, C. (2005). Current status of therapy of solid tumors. Journal of Nuclear Medicine, 46(1): 141S-50S. Patel, D., Shukla, S., & Gupta, S. (2007). Apigenin and cancer chemoprevention: progress, potential and promise. International Journal of Oncology, 30(1): 233-45.
  2. Newman, D.J., Cragg, G.M., & Snader, K.M. (2003). Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products, 66(7): 1022-37.
  3. Newman, D.J., & Cragg, G.M. (2007). Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70(3): 461-77.
  4. Davis, P.H. Flora of Turkey and The East Aegean Islands. University Press,
  5. Edinburgh (1978).
  6. Khan, I., & Aqil, M. (1993). Isolation and identification of pectolinarin and mannitol from Kickxia ramosissima (Wall). Chemical and Environmental Research, 2(3): 287-89.
  7. Amin, A., Tuenter, E., Foubert, K., Iqbal, J., Cos, P., Maes, L., et al. (2017). In vitro and in silico antidiabetic and antimicrobial evaluation of constituents from Kickxia ramosissima (Nanorrhinum ramosissimum). Frontiers in Pharmacology, 8: 1-12.
  8. Singh, M., & Prakash, L. (1987). A New Flavone Glycoside and Other Chemical-Constituents from Kickxia Ramosissima Wall - (Scrophulariaceae). Pharmazie, 42(7): 490-91.
  9. Al-Rehaily, A.J., Abdel-Kader, M.S., Ahmad, M.S., & Mossa, J.S. (2006). Iridoid glucosides from Kickxia abhaica D.A Sutton from Scrophulariaceae. Phytochemistry, 67(5): 429-32.
  10. Ghani, N.A., Ahmat, N., Ismail, N.H., & Zakaria, I. (2011). Flavonoid constituents from the stem bark of polyalthia cauliflora var. Cauliflora. Australian Journal of Basic and Applied Sciences, 5(8): 154-58.
  11. Erenler, R., Meral, B., Sen, O., Elmastas, M., Aydin, A., Eminagaoglu, O., et al. (2017). Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharmaceutical Biology, 55(1): 1646-53.
  12. Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A.S., Elmastas, M., et al. (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture, 96(3): 822-36.
  13. Demirtas, I., Erenler, R., Elmastas, M., & Goktasoglu, A. (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry, 136(1): 34-40.
  14. Elmastas, M., Erenler, R., Isnac, B., Aksit, H