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Journals / Haydarpaşa Numune Medical Journal / 2022 / Cilt: 62 - Sayı: 2

Effects of Topical Coenzyme Q10 on Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with OpenAngle Glaucoma

Ece TURAN VURAL
Okşan ALPOĞLAN
Meltem TOKLU
Ayşegül ERSANLI
Muhammed Nurullah BULUT
Serhat İMAMOĞLU
Pages
190–194
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The combination of CQ10 and Vit E treatment can have beneficial effects on the RNFL in primary OAG patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Recent studies have shown that retinal ganglion cell apoptosis is of great importance in the pathophysiology of glaucoma.
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Key Findings & Data:Coenzyme Q10 (CQ10) is a molecule used for its neuroprotective effect in the treatment of glaucoma.
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Conclusion & Impact:The combination of CQ10 and Vit E treatment can have beneficial effects on the RNFL in primary OAG patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Recent studies have shown that retinal ganglion cell apoptosis is of great importance in the pathophysiology of glaucoma. Coenzyme Q10 (CQ10) is a molecule used for its neuroprotective effect in the treatment of glaucoma. Our aim was to evaluate the effect of CQ10 and Vitamin E (Vit E) combination on retinal nerve fiber layer (RNFL) and ganglion cell complex in open-angle glaucoma (OAG) patients by optical coherence tomography (OCT). Methods: In this retrospective study, thirty-one OAG patients with glaucoma in both eyes (intraocular pressure [IOP] 0.05) at baseline. There was a significant increase in the average RNFL value at baseline and after 6 months of treatment in the GC group (p=0.045). In the GC group, the differences in the superior RNFL and the average RNFL values after 6 months were significantly greater than those recorded in the GT group (p=0.019, p=0.034, respectively). Discussion and Conclusion: In our study, we found a statistically significant effect of CQ10 on the RNFL. The combination of CQ10 and Vit E treatment can have beneficial effects on the RNFL in primary OAG patients.

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Cite This Article

VURAL, E. T., ALPOĞLAN, O., TOKLU, M., ERSANLI, A., BULUT, M. N., İMAMOĞLU, S. (2022). Effects of Topical Coenzyme Q10 on Retinal Nerve Fiber Layer and Ganglion Cell Complex in Patients with OpenAngle Glaucoma. Haydarpaşa Numune Medical Journal, Cilt: 62 - Sayı: 2, 190–194. https://ajindex.com/articles/535849

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