Journals / Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2003 / Cilt: 43 - Sayı: 1

A case of toxic epidermal necrolysis responded well to treatment

Tedaviye iyi cevap veren bir toksik epidermal nekroliz olgusu

Pages
48–50
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

He was successfully treated in spite of poor prognostic factors such as old age, prerenal azotemia, lymphopenia, late withdrawal of the causative agent, and the involvement of 80% of total body surface area.

📌 3 Key Takeaways

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Objective & Hypothesis:Toxic epidermal necrolysis is an acute, exfoliative, mostly drug induced skin and mucosal disorder which has 5-50% mortality rate.
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Key Findings & Data:In this report, an 84-year-old man with toxic epidermal necrolysis due to trimethoprim-sulfamethoxazole is presented.
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Conclusion & Impact:He was successfully treated in spite of poor prognostic factors such as old age, prerenal azotemia, lymphopenia, late withdrawal of the causative agent, and the involvement of 80% of total body surface area.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Toxic epidermal necrolysis is an acute, exfoliative, mostly drug induced skin and mucosal disorder which has 5-50% mortality rate. Especially old age, area of necrolysis, elevated serum urea and creatinine levels, and multiple drug intake, high glucose levels, neutropenia, lymphopenia, thrombocytopenia are considered among the poor prognostic factors. In this report, an 84-year-old man with toxic epidermal necrolysis due to trimethoprim-sulfamethoxazole is presented. He was successfully treated in spite of poor prognostic factors such as old age, prerenal azotemia, lymphopenia, late withdrawal of the causative agent, and the involvement of 80% of total body surface area.

Özet

Toksik epidermal nekroliz çoğunlukla ilaçların uyardığı, %5-50 mortalite oranına sahip, akut, eksfolyatif bir deri ve mukoza hastalığıdır. Prognozu kötüleştiren faktörler arasında ileri yaş, nekroz alanının genişliği ve ürekreatinin yüksekliği başta olmak üzere, çok sayıda ilaç alınması, neden olan ilacın geç kesilmesi, glikoz düzeylerinin yüksek olması, nötropeni, lenfopeni ve trombositopeni sayılmaktadır. Bu yazıda trimetoprim-sülfametoksazol kullanımına bağlı toksik epidermal nekroliz gelişen, ileri yaş, prerenal azotemi, lenfopeni, tabloya neden olan ilacın geç kesilmesi, vücut alanının % 80'inin tutulumu gibi kötü prognostik faktörlere sahip olmasına rağmen başarıyla tedavi edilen, 84 yaşındaki bir erkek hasta sunulmaktadır.

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Cite This Article

GÖKTAY, F., AYDINGÖZ, İ. E., GÜNEY, O., PEKCAN, Ş., CAFERLER, N., KAYA, Ü. (2022). A case of toxic epidermal necrolysis responded well to treatment. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 43 - Sayı: 1, 48–50. https://ajindex.com/articles/535749

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