Journals / Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2005 / Cilt: 45 - Sayı: 1

Haemodynamic effects of remifentanil-propofol and remifentanil-midazolam combinations in total intravenous aneasthesia

Total intravenöz anestezide remifentanil-propofol ile remifentanil-midazolam kombinasyonlarının değerlendirilmesi

Pages
30–34
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results indicate that in total intravenous anaesthesia midazolam may be a good alternative to propofol.

📌 3 Key Takeaways

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Objective & Hypothesis:Anaesthesia can be maintained with volatile agents or continuous infusions of short-acting intravenous anesthetics. 40 patients, ASA l-ll, ages ranging 18-70 years scheduled for abdominal surgery were included in our study.
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Key Findings & Data:Atropin (0.5 mg i.m.) was administered for premedication.
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Conclusion & Impact:Our results indicate that in total intravenous anaesthesia midazolam may be a good alternative to propofol.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Anaesthesia can be maintained with volatile agents or continuous infusions of short-acting intravenous anesthetics. 40 patients, ASA l-ll, ages ranging 18-70 years scheduled for abdominal surgery were included in our study. Atropin (0.5 mg i.m.) was administered for premedication. Propofol (2 mg/kg i.v.) was administered in group P, midazolam (0.3 mg/kg i.v.) was administered in group M, after administration of remifentanil (1 ug/kg i.v.) in each group. Anesthesia was maintained with N20/02 (50%), R infusion (0.5 ug/kg/min) plus P (75 ug/kg/min) in group P and M (0.07 mg/kg/h) in group M. There was no significant difference in SAP, DAP, MAP and HR during any perioperative periods between groups P and M. During perioperative period HR were statistically lower comparing with the initial measurements in both groups. Our results indicate that in total intravenous anaesthesia midazolam may be a good alternative to propofol.

Özet

Bu çalışmada, total intravenöz anestezide propofol ve midazolamın, remifentanil ile birlikte infüzyon şeklinde kullanımının peroperatif hemodinami üzerine etkilerinin karşılaştırılması amaçlandı. Elektif abdominal cerrahi planlanan 40 hasta çalışmaya alındı. Hastalara premedikasyon olarak atropin 0.5 mg i.m. uygulandı. Tüm hastalara remifentanil 1 ug/kg i.v. verilmesini takiben, Grup P'deki hastalara propofol 2 mg/kg i.v., Grup M'deki hastalara midazolam 0.3 mg/kg i.v. uygulandı. Anestezi idamesi oksijen içinde %50 N20 inhalasyonu ve remifentanil 0.5 ug/kg/dk perfüzyonu ile birlikte Grup P'deki hastalarda propofol 75 ug/kg/dk, Grup M'deki hastalarda midazolam 0.07 mg/kg/sa perfüzyonları ile sağlandı, iki grup hasta birbirleri ile kıyaslandığında, peroperatif hiçbir dönemde sistolik arter basıncı, diyas-tolik arter basıncı, ortalama arter basıncı ve kalp hızı ölçümlerinde istatistiksel olarak anlamlı farklılık izlenmedi. Peroperatif dönemde her iki grup hastada da kalp atım hızları başlangıç değerleri ile kıyaslandığında istatistiksel olarak düşük olarak seyretti. Total intravenöz anestezide midazolamın propofole iyi bir alternatif olabileceği kanaatine varıldı.

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Cite This Article

BOMBACI, E., BOSNA, G., AYDIN, N., ERGÜN, G. E. (2022). Haemodynamic effects of remifentanil-propofol and remifentanil-midazolam combinations in total intravenous aneasthesia. Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 45 - Sayı: 1, 30–34. https://ajindex.com/articles/535645

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