AI Summary & Key Takeaways
AI InsightThickness of posterior wall and interventri-cular septum and isovolumetric relaxation time were also higher in albuminuria group (respectively, p
📌 3 Key Takeaways
Abstract
Association of albuminuria with impaired aortic elasticity and left ventricular diastolic dysfunction in type 2 diabetes Albuminuria is an early marker of diabetic nephropaty and has been shown to strongly predict future cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus.There is accelerated atherosclerosis in diabetes mellitus.The present study tested the hypothesis suggesting that the albuminuria reflects the impaired aortic elastic properties and it also associated with diastolic dysfunctionin type 2 diabetes mellitus. The study population consisted of 100 type 2 diabetic patients, (69 female, mean age 52.6±9.4 years). Aortic strain and distensibility were used as aortic elasticity parameters. Normoalbuminuria and albuminuria were recognized as an albumin excretion rate 30 mg/dl respectively.Aortic strain and distensibility were significantly increased in patients with albuminuria compared to normoal-buminuria. Thickness of posterior wall and interventri-cular septum and isovolumetric relaxation time were also higher in albuminuria group (respectively, p
Özet
Albuminüri diyabetik nefropatinin erken bir belirtecidir ve tip 2 diyabetik hastalarda kardiyovaskuler mortalite ve morbiditeyle ilişkili olduğu ortaya konmuştur. Diyabet aterosklerozun doğal seyrini hızlandırmakta ve daha yaygın aterosklerotik lezyonla birlikte daha fazla ko-roner damar tutulumuna yol açmaktadır. Bu çalışmamızın amacı, Tip 2 diyabetik hastalarda albuminürinin aortun elastik özellikleriyle ve diyastolik disfonksiyonla ilişkisini ortaya koymaktır. Çalışmaya 100 hasta (69 kadın, ortalama yaş 52.6±9.4 yıl) dahil edildi. Albuminüri düzeyi 30 mg/dl olan hastalar (n=50) albuminürik tip 2 diyabetik hastalar olarak tanımlandı. Aort elastisite parametreleri olarak; aortik gerilme ve esneklik alındı. Normoalbuminürik grupta aortik gerilme ve esneklik ölçüm değerleri, albuminürik gruptan istatistiksel olarak anlamlı derecede yüksek saptandı (p