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Journals / Haseki Tıp Bülteni / 2018 / Cilt: 56 - Sayı: 4

Are Mean Platelet Volume and Neutrophil-toLymphocyte Ratio Valuable in The Early Detection of System Involvements in Henoch-Schönlein Purpura?

Ortalama Trombosit Hacmi ve Nötrofil-Lenfosit Oranı Henoch-Schönlein Purpurası’nda Sistem Tutulumlarının Erken Saptanmasında Değerli mi?

Meltem EROL
Abdulrahman ÖZEL
Özlem BOSTAN GAYRET
Fatih METE
Özgül YİĞİT
Pages
279–285
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

No statistically significantdifference was observed in the MPV and NLR values between patientswith and without GIS involvement, renal involvement and arthritis.Conclusion: It is thought that MPV and NLR cannot be used as laboratoryparameters in the early detection of system involvement in HSP.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Henoch-Schönlein purpura (HSP) is the most common type ofvasculitis in childhood, and severe complications due to intestinal andrenal involvement can be observed.
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Key Findings & Data:In this study, it was planned toinvestigate the value of mean platelet volume (MPV) and neutrophil-tolymphocyteratio (NLR) in early detection of system involvement in HSP.Methods: A total of 119 patients diagnosed with HSP and 75healthy controls were included in the study.
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Conclusion & Impact:No statistically significantdifference was observed in the MPV and NLR values between patientswith and without GIS involvement, renal involvement and arthritis.Conclusion: It is thought that MPV and NLR cannot be used as laboratoryparameters in the early detection of system involvement in HSP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Henoch-Schönlein purpura (HSP) is the most common type ofvasculitis in childhood, and severe complications due to intestinal andrenal involvement can be observed. In this study, it was planned toinvestigate the value of mean platelet volume (MPV) and neutrophil-tolymphocyteratio (NLR) in early detection of system involvement in HSP.Methods: A total of 119 patients diagnosed with HSP and 75healthy controls were included in the study. Data on age, gender andphysical examination as well as complete blood count, complete urineexamination and faecal occult blood test were obtained from the filesof the patients.Results: Gastrointestinal system (GIS) involvement was detected in41 patients (34.45%), renal involvement in 35 patients (29.41%) andarthritis was detected in 21 patients (17.65%). It was determinedthat the mean hemoglobin (p=0.02) and MPV values (p=0.0001) owere significantly lower and the mean leukocyte (p=0.0001), platelet(p=0.0001), neutrophil (p=0.0001) count and NLR value (p=0.0001) weresignificantly higher in patients than in controls. No statistically significantdifference was observed in the MPV and NLR values between patientswith and without GIS involvement, renal involvement and arthritis.Conclusion: It is thought that MPV and NLR cannot be used as laboratoryparameters in the early detection of system involvement in HSP.

Özet

Amaç: Henoch-Schönlein purpurası (HSP) çocukluk çağının en sık görülen vasküliti olup intestinal ve renal tutuluma bağlı ağır komplikasyonlar görülebilir. Çalışmamızda HSP’nin sistem tutulumlarını erken saptamada ortalama trombosit hacminin (OTH) ve nötrofil lenfosit oranının (NLO) değerlendirilmesi amaçlanmıştır. Yöntemler: HSP tanısı alan 119 hasta ve 75 sağlıklı kontrol çalışmaya alındı. Hastaların yaşı, cinsiyeti, fizik muayene bulguları, tam kan sayımı, tam idrar incelemesi, dışkıda gizli kan tetkiki dosyalarından kaydedildi. Bulgular: Hastaların 41’inde gastrointestinal sistem (GİS) tutulumu (%34,45), 35’inde renal tutulum (%29,41), 21’inde artrit (%17,65) tespit edildi. Hastaların hemoglobin (p=0,02) ve OTH (p=0,0001) değeri ortalaması anlamlı derecede düşük, lökosit (p=0,0001), trombosit (p=0,0001), nötrofil (p=0,0001) sayısı ve NLR değeri (p=0,0001) ortalaması anlamlı derecede yüksek bulunmuştur. GİS tutulumu, renal tutulumu ve artriti olan ve olmayan hastaların ortalama OTH ve NLO değeri arasında istatistiksel olarak anlamlı farklılık gözlenmemiştir. Sonuç: HSP’de sistem tutulumlarını erken saptanmada OTH ve NLO’nun laboratuvar parametresi olarak kullanılamayacağını düşünmekteyiz.

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Cite This Article

EROL, M., ÖZEL, A., GAYRET, Ö. B., METE, F., YİĞİT, Ö. (2022). Are Mean Platelet Volume and Neutrophil-toLymphocyte Ratio Valuable in The Early Detection of System Involvements in Henoch-Schönlein Purpura?. Haseki Tıp Bülteni, Cilt: 56 - Sayı: 4, 279–285. https://ajindex.com/articles/535107

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References (13)

  1. Pohl M. Henoch–Schönlein purpura nephritis. Pediatr Nephrol 2015;30:245-52.
  2. Barut K, Sahin S, Adrovic A, Kasapcopur O. Diagnostic approach and current treatment options in childhood vasculitis. Turk Pediatri Ars 2015;50:194-205.
  3. Ercan G, Kasapçopur O, Akdenizli E, Arisoy N. The role of streptococcal infection in Henoch-Schönlein purpura. J Trop Pediatr 2004;50:187-8.
  4. Rigante D, Castellazzi L, Bosco A, Esposito S. Is there a crossroad between infections, genetics, and HenochSchönlein purpura? Autoimmun Rev 2013;12:1016-21.
  5. Dedeoglu F, Sundel R. Vasculitis in children. Pediatrics Clinics 2005;52:547-75.
  6. Saulsbury FT, Kesler RW. Thrombocytosis in Henoch-Schonlein purpura. Clin Pediatr (Phila) 1983;22:185-7.
  7. Lin SJ, Huang JL, Hsieh KH. Clinical and laboratory correlation of acute Henoch-Schonlein purpura in children. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1998;39:94-8.
  8. Uslu AU, Kucuk A, Sahin A, et al. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis 2015;18:731-5.
  9. Wu Y, Chen Y, Yang X, et al. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol 2016;36:94-9.
  10. Gayret OB, Erol M, Tekin Nacaroglu H. The Relationship of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Gastrointestinal Bleeding in Henoch-Schonlein Purpura. Iran J Pediatr 2016;26:e8191. Makay B, Gucenmez OA, Duman M, Unsal E. The relationship of neutrophil-to-lymphocyte ratio with gastrointestinal bleeding in Henoch-Schonlein purpura. Rheumatol Int 2014;34:1323-7.
  11. Makay B, Türkyilmaz Z, Duman M, Unsal E. Mean platelet volume in Henoch-Schönlein purpura: relationship to gastrointestinal bleeding. Clin Rheumatol 2009;28:1225-8.
  12. Ruperto N, Ozen S, Pistorio A, EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation. Ann Rheum Dis 2010;69:790-7. Saulsbury FT. Henoch-Schönlein purpura in children report of 100 patients and review of the literature. Medicine 1999;78:395-409.
  13. Trapani S, Micheli A, Grisolia F, et al. Henoch Schonlein Purpura in Childhood: Epidemiological and Clinical Analysis of 150 Cases Over a 5-year Period and Review of Literature. Semin Art