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Journals / Haseki Tıp Bülteni / 2020 / Cilt: 58 - Sayı: 5

Microsatellite Instability in Ovarian Invasive and Borderline Epithelial Tumors and Comparison with Prognostic Parameters

Overin İnvazif ve Borderline Epitelyal Tümörlerinde Mikrosatellit İnstabilite ve Prognostik Parametreler ile Karşılaştırılması

Aylin Ege GÜL
Sevinç HALLAÇ KESER
Sibel SENSU
Filiz İlhan TÜRKEL
Nagehan ÖZDEMİR BARIŞIK
Pages
452–459
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The only correlation was detected between tumortype and MMR protein loss (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Ovarian cancers, 20% of which are hereditary, areconsidered the most lethal gynecological malignancies.
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Key Findings & Data:In thisstudy, we aimed to determine microsatellite instability status ininvasive and borderline epithelial ovarian tumors diagnosed viaimmunohistochemistry in our clinic and compare the results withseveral prognostic parameters and survival.Methods: In this retrospective study, 159 epithelial ovariantumors were evaluated for age, tumor type, histological gradeand Federation of Gynecology and Obstetrics (FIGO) stage as wellas survival.
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Conclusion & Impact:The only correlation was detected between tumortype and MMR protein loss (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Ovarian cancers, 20% of which are hereditary, areconsidered the most lethal gynecological malignancies. Defectson DNA mismatch repair (MMR) genes are responsible forhereditary ovarian tumors related with Lynch syndrome. In thisstudy, we aimed to determine microsatellite instability status ininvasive and borderline epithelial ovarian tumors diagnosed viaimmunohistochemistry in our clinic and compare the results withseveral prognostic parameters and survival.Methods: In this retrospective study, 159 epithelial ovariantumors were evaluated for age, tumor type, histological gradeand Federation of Gynecology and Obstetrics (FIGO) stage as wellas survival. MMR protein expression was immunohistochemicallyexamined and absence of nuclear staining in tumor cells wasconsidered MMR protein expression loss. All prognosticparameters were compared and analysed statistically.Results: MMR protein expression loss showed no statisticallysignificant relationship with FIGO stage, age, histological grade,and survival. The only correlation was detected between tumortype and MMR protein loss (p

Özet

Amaç: Yüzde 20’si herediter olan over kanseri en ölümcül jinekolojik malignitedir. DNA mismatch onarım (MMR) genlerindeki defektler, Lynch sendromu ile ilişkili herediter over tümörlerinden sorumludur. Bu çalışmada invazif ve borderline epitelyal over tümörlerinde mikrosatellit instabilite araştırılmakta olup sonuçlar çeşitli prognostik parametreler ile karşılaştırılmıştır. Yöntemler: Bu retrospektif çalışmada 159 epitelyal over tümörü, yaş, tümör tipi, histolojik grade ve Uluslararası Kadın Doğum Dernekleri Federasyonu (FIGO) evreleme yanısıra sağkalım yönünden incelenmiştir. MMR ekspresyonu immünohistokimyasal olarak araştırılmış olup tümör hücrelerinde nükleer boyanma kaybı, MMR ekspresyon kaybı olarak kabul edilmiştir. Tüm prognostik parametreler karşılaştırılmış ve tüm veriler istatistiksel olarak incelenmiştir. Bulgular: MMR protein ekspresyon kaybı ile FIGO evresi, yaş, histolojik grade ve sağkalım arasında istatistiksel olarak anlamlı ilişki saptanmamıştır. Sadece tümör tipi ile MMR kaybı arasında anlamlı bir korelasyon bulunmuştur (p

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Cite This Article

GÜL, A. E., KESER, S. H., SENSU, S., TÜRKEL, F. İ., BARIŞIK, N. Ö. (2022). Microsatellite Instability in Ovarian Invasive and Borderline Epithelial Tumors and Comparison with Prognostic Parameters. Haseki Tıp Bülteni, Cilt: 58 - Sayı: 5, 452–459. https://ajindex.com/articles/535023

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