Journals / Ulusal Cerrahi Dergisi / 2009 / Cilt: 25 - Sayı: 2

A new practice of trichloroaceticacid peeling: reduction of second primary skin cancer

İkinci primer cilt kanserini önlemek için trikloroasetik asit ile peeling

Pages
56–61
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Trichloroaceticacid peeling provides a prophylactic effect against the development of skin malignancies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Exposure to solar radiation is a major cause of nonmelanoma skin cancer.
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Key Findings & Data:Material and Methods: Between 1999 and 2004, 102 patients with skin cancer were treated surgically.
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Conclusion & Impact:Conclusion: Trichloroaceticacid peeling provides a prophylactic effect against the development of skin malignancies.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Deri neoplazmları · Trikloroasetik asit · İzleme çalışmaları

Abstract

Purpose: Exposure to solar radiation is a major cause of nonmelanoma skin cancer. Topical application of chemical peeling agents to reverse actinic damage of skin is a well-established, accepted clinical practice. Subclinic malignant lesions are generally seen with skin cancers simultaneously. In this paper, we evaluated effectiveness of the tricholoroacetic acid peeling to treatment of subclinic lesions. Material and Methods: Between 1999 and 2004, 102 patients with skin cancer were treated surgically. In addition to the surgical treatment of malignant lesions, full-face chemical peeling with 35-40% trichloroacetic acid was applied during the same operative session to 48 patients whose faces had extensively sun-damaged skin. The ages of patients were varied between 51 and 93. They were followed- up 1-5 years. The effectiveness of the TCA treatment was evaluated with pathologic examinations. Result: Second primary skin cancer was observed in only 3 patients who were applied TCA peeling. TCA peeling causes histologic changes such as correction of epidermal atrophy and atypia as well as deposition of new subepidermal collagen. Conclusion: Trichloroaceticacid peeling provides a prophylactic effect against the development of skin malignancies.

Özet

Amaç: Melanom dışı cilt kanserlerinin en önemli sebebi güneş ışığıdır. Kimyasal peeling aktinik yaralanmalarda oldukça faydalıdır. Subklinik malign lezyonlar genellikle deri kanserleriyle beraber görülürler. Bu çalışmada, subklinik lezyonların tedavisi için trikloroasetik asitle (TCA) peelingin etkinliğini retrospektif olarak değerlendirdik. Gereç ve Yöntemler: 1999 ile 2004 yılları arasında 102 hasta cilt kanseri nedeniyle tedavi edildi. Yüzlerinde aşırı aktinik hasar olan 48 hastanın yüzüne, malign lezyonların cerrahi tedavisine ek olarak, %35-40'lık trikoloroasetik asitle peeling yapıldı. Hastalar 51 ile 93 yaşları arasındaydı. Takip süresi 1-5 yıldır. TCA tedavisinin efektivitesi patolojik olarak değerlendirildi. Bulgular: İkinci primer cilt kanseri, peeling yapılan hastaların sadece 3'ünde görüldü. TCA peeling sonrası histolojik olarak epidermal atrofide, atipide düzelme ve yeni subdermal kollajen birikimi görülmüştür. Sonuç: TCA peelingin, deri kanseri oluşumuna karşı etkili olduğunu düşünmekteyiz.

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Cite This Article

AVCI, G., AKÖZ, T., GÜL, A. E. (2009). A new practice of trichloroaceticacid peeling: reduction of second primary skin cancer. Ulusal Cerrahi Dergisi, Cilt: 25 - Sayı: 2, 56–61. https://ajindex.com/articles/325531

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