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Journals / Harran Üniversitesi Veteriner Fakültesi Dergisi / 2021 / Cilt: 10 - Sayı: 1

Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats

Hipotiroidili Ratlarda Koenzim Q10'un Plazma Parametreleri Üzerine Etkisi

Oğuzcan KOCA
Durmuş HATİPOĞLU
Ali Osman İNAN
Zafer DURGUN
Pages
66–72
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was observed in the research that hypothyroidism administration (group H) decreased plasma glucoseand triglyceride values (p

📌 3 Key Takeaways

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Objective & Hypothesis:This research was conducted to determine the effect of Coenzyme Q10 (CoQ10) on blood glucose, total protein,triglyceride, and total cholesterol levels in rats for that experimental hypothyroidism was induced.
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Key Findings & Data:A total of 32 healthyadult male Wistar Albino rats were used as a material in the research.
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Conclusion & Impact:It was observed in the research that hypothyroidism administration (group H) decreased plasma glucoseand triglyceride values (p
🔬Design:Lab & Field Experiment
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This research was conducted to determine the effect of Coenzyme Q10 (CoQ10) on blood glucose, total protein,triglyceride, and total cholesterol levels in rats for that experimental hypothyroidism was induced. A total of 32 healthyadult male Wistar Albino rats were used as a material in the research. After the adaptation period of animals for ten days,the main research period was conducted for a total of three weeks. The rats housed as four rats in each cage during theresearch were divided into four experimental groups as control (K), CoQ10 (C), Hypothyroid (H), and CoQ10+Hypothyroid(CH). CoQ10 was administered intraperitoneally every day to the group C animals. In addition, propylthiouracil (PTU) wasadded daily to the water of rats in group H to induce experimental hypothyroidism. Both CoQ10 and PTU administrationwas performed on the animals in the group HC. At the end of the trial period, blood was drawn from the hearts of rats in allgroups. Glucose, total protein, triglyceride, and total cholesterol levels were determined in plasma samples obtained fromblood samples. It was observed in the research that hypothyroidism administration (group H) decreased plasma glucoseand triglyceride values (p

Özet

Deneysel olarak hipotiroidizm oluşturulmuş ratlarda Koenzim Q10 (KoQ10)’un kan glikoz, total protein, trigliserit ve total kolesterol düzeyleri üzerindeki etkisinin belirlenmesi amaçlandı. Araştırmada materyal olarak sağlıklı toplam 32 adet yetişkin erkek Wistar Albino ırkı rattan yararlanıldı. Hayvanların10 günlük adaptasyon süresini takiben esas araştırma dönemi toplam 3 hafta sürdürüldü. Çalışma süresince her kafeste 4 rat olacak şekilde barındırılan ratlar kontrol (K), KoQ10 (C), Hipotiroid (H) ve KoQ10+ Hipotiroid (CH) olmak üzere 4 deneme grubuna ayrıldı. C grubu hayvanlara her gün intraperitoneal olarak KoQ10 uygulandı. Deneysel hipotiroidizm oluşturmak amacıyla, H grubundaki ratların sularına günlük propiltiyourasil (PTU) ilave edildi. HC grubundaki hayvanlara ise hem KoQ10, hem de PTU uygulaması yapıldı. Deneme sonunda gruplardaki deneklerden genel anestezi altında kardiak punksiyon ile yeterli oranda kan alındı ve plazmaları elde edildi. Elde edilen plazma örneklerinden glikoz, total protein, trigliserit ve total kolesterol düzeyleri belirlendi. Araştırmada, hipotiroidizm oluşturulmasının, kontrol grubu ile kıyaslandığında plazma glikoz ve trigliserit değerlerini düşürdüğü (p

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Cite This Article

KOCA, O., HATİPOĞLU, D., İNAN, A. O., DURGUN, Z. (2022). Effect of Coenzyme Q10 on Plasma Parameters in Hypothyroıd Rats. Harran Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 10 - Sayı: 1, 66–72. https://ajindex.com/articles/534157

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