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Journals / Harran Üniversitesi Veteriner Fakültesi Dergisi / 2020 / Cilt: 9 - Sayı: 1

Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats

İbrahim AKTAŞ
Dilek BAYRAM
Pages
42–48
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

SLY can protect rat kidney against VPA induced damage via anti-oxidative effect and might be useful for reducing the severity of kidney injuries.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study; we aimed to investigate the protective effects of silymarin (SLY) against kidney damage on valproic acid (VPA)-induced rats using histological and biochemical evaluations.
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Key Findings & Data:Experimental procedures were performed on 21 male Sprague Dawley rats.
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Conclusion & Impact:SLY can protect rat kidney against VPA induced damage via anti-oxidative effect and might be useful for reducing the severity of kidney injuries.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Valproic acid · Silymarin · Kidney injury

Özet

In this study; we aimed to investigate the protective effects of silymarin (SLY) against kidney damage on valproic acid (VPA)-induced rats using histological and biochemical evaluations. Experimental procedures were performed on 21 male Sprague Dawley rats. Rats were divided randomly into three groups: group 1, control; group 2, VPA; group 3, VPA+SLY. The control group was given 1 mL 0.9 % NaCl orally for 14 days. The VPA group was given 500 mg/kg/day VPA per os for 14 days. The VPA+SLY group was given 500 mg/kg/day VPA and 100 mg/kg/day SLY per os for 14 days. SLY treatment decreased the levels of creatinine (Cr) and blood urea nitrogen (BUN) levels significantly (p < 0.05). In addition, increased amount of thiobarbitüric acid reactive substance (TBARS) and decreased levels of glutathione (GSH) with VPA were significantly suppressed by SLY in kidney tissue (p < 0.05). Histologically, the extent of kidney damage was remarkably lower in the VPA+SLY group (p < 0.005). In addition, VPA+SLY group had decreased oxidative stress, increased antioxidant activity and decreased histopathological changes compared to VPA group. This study revealed that the kidney damage induced by VPA was attenuated with SLY administration. SLY can protect rat kidney against VPA induced damage via anti-oxidative effect and might be useful for reducing the severity of kidney injuries.

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Cite This Article

AKTAŞ, İ., BAYRAM, D. (2022). Investigation of the effects of silymarin on valproic acid-induced kidney damage in rats. Harran Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 9 - Sayı: 1, 42–48. https://ajindex.com/articles/532928

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References (12)

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