Immunolocalization of fibronectin and transforming growth factor- $beta$ 1 in the thyroid, parathyroid and adrenal glands of male rats treated with carbendazım
The immunreactivity for fibronectin and transforming growth factor- $beta$ were increased in adrenal, thyroid and parathyroid glands in 300 and 600 mg/kg/day groups depending on advancing doses.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:The aim of this study is was is to evaluate the immunolocalization for fibronectin and transforming growth factor- $beta$ 1 in adrenal, thyroid and parathyroid glands of rats treated with carbendazim.
📊
Key Findings & Data:The Swiss albino male rats were exposed to 0, 150, 300 and 600 mg/kg/day carbendazim doses by gavage for 3.5 months.
💡
Conclusion & Impact:The immunreactivity for fibronectin and transforming growth factor- $beta$ were increased in adrenal, thyroid and parathyroid glands in 300 and 600 mg/kg/day groups depending on advancing doses.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
The aim of this study is was is to evaluate the immunolocalization for fibronectin and transforming growth factor- $beta$ 1 in adrenal, thyroid and parathyroid glands of rats treated with carbendazim. The Swiss albino male rats were exposed to 0, 150, 300 and 600 mg/kg/day carbendazim doses by gavage for 3.5 months. The thyroid, parathyroid and adrenal glands of rats killed by cervical dislocation were removed and paraffin blocks were prepared. Then, the tissue sections stained by the PAP method were examined. The immunreactivity for fibronectin and transforming growth factor- $beta$ were increased in adrenal, thyroid and parathyroid glands in 300 and 600 mg/kg/day groups depending on advancing doses.
🔖
Cite This Article
BARLAS, N., SELMANOĞLU, G., KOÇKAYA, E. A., HAYRETDAĞ, S. (2022). Immunolocalization of fibronectin and transforming growth factor- $beta$ 1 in the thyroid, parathyroid and adrenal glands of male rats treated with carbendazım. Hacettepe Journal of Biology and Chemistry, Cilt: 33 - Sayı:, 7–21. https://ajindex.com/articles/529406
Burland, T.G. and Gull, K. Mode of action of antifungal agents. In: Trinci, A.P.J., and Ryley, J.F. (Eds.); pp. 299-320. Cambridge Univ. Press, Cambridge, 1984
Birkett, C.R., Coulson, C, Pogson, C.I. and Gull, K. Inhibition of secretion of proteins and triacylglycerol from isolated rat hepatocytes mediated by benzimidazole carbamate antimicrotubule agents. Biochem Pharmacology, 30, 1629-33,1981
Goldman, J.M., Rehnberg, G.L., Cooper, R.L., Gray, L.E., Hein, J.F. and McElroy, W.K. Effects of the benomyl metabolite, carbendazim, on the hypothalamic-pituitary reproductive axis in the male rat. Toxicology, 57,173-82, 1989
Gray, L.E., Ostby, J.J., Linder, R., Goldman, J., Rehnberg, G. and Cooper, R. Carbendazim-induced alterations of reproductive development and function in the rat and hamster. Fundamental and Applied Toxicology, 15, 281-97, 1990
Carderelli, P.M. and Pierschbacher, M.D. Identification of fibronectin receptors on T lymphocytes. The Journal of Cell Biology, 106,499-506,1987
Limper, A.H. and Roman, J. Fibronectin: A versatile matrix protein with roles in thoracic development, repair and infection. Chest, 101,1663-73,1992
Bhalla, D.K., Gupta, S.K. and Reinhart, P.G. Alteration of epithelial integrity, alkaline phosphate activity and fibronectin expression in lungs of rats exposed to ozone. J. Tox. and Environ., Health, Part A. 56,329-43,1999
Date, M., Matsuzaka, K., Matsushita, M., Sakitani, K., Shibano, K., Okajima, A., Yamamoto, C, Ogata, N., Okumura, T., Seki, T., Kubota, Y., Kan, M., McKeehan, W.L. and Inove, K. Differential expression of TGF $beta$ and its receptors in hepatocytes and nonparanchymal cells of liver after $CC1_4$ administration. J. of Hepatology, 28(4), 572-81, 1998
Kuncio, G.S., Neilson, E.G. and Haverty, T. Mechanisms of tubulointerstitial fibrosis. Kidney Int., 39,550-56,1991
Roberts, A.B., McCune, B.K. and Sporn, M B. TGF- $beta$: Regulation of extracellular matrix. Kidney Int., 41, 557-59, 1992
Suzuki, K., Uetsuka, K., Nakayama, H. and Doi, K. Kinetics of TGF- $beta$ 1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. Int. J. Exp. Path., 80,125-32,1999
Boccuzzi, A., Terzolo, M., Cappia, S., De Giuli, P., De Risi, C, Leonardo, E., Bovio, S., Borriero, M., Paccotti, P. and Angeli, A. Different immunohistochemical patterns of TGF- $beta$ 1 expression in benign and malignant adrenocortical tumours. Clinical Endocrinology