Adhesion and proliferation of cardiac fibroblast cells has been appreciably good which is due to surface reorganisation and generation of synergistic hydrophilic-hydrophobic surface.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Injectable and biodegradable hydrogel material based on polyethylene glycol terminated poly(propylene fumarate)(PEG-PPF-PEG)/ acrylamide have been developed and evaluated for cardiac applications.
📊
Key Findings & Data:The present material are non cytotoxic to L-929 fibroblast and compatible with the cardiac fibroblast cells.
💡
Conclusion & Impact:Adhesion and proliferation of cardiac fibroblast cells has been appreciably good which is due to surface reorganisation and generation of synergistic hydrophilic-hydrophobic surface.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Injectable and biodegradable hydrogel material based on polyethylene glycol terminated poly(propylene fumarate)(PEG-PPF-PEG)/ acrylamide have been developed and evaluated for cardiac applications. The present PEG-PPF-PEG resin undergoes fast setting with acrylamide with low exothermic temperature and mechanical properties equivalent to that of cardiac tissue. The chemically cross linked hydrogels undergo swelling in Ringer’s solution prior to degradation. The present material are non cytotoxic to L-929 fibroblast and compatible with the cardiac fibroblast cells. Adhesion and proliferation of cardiac fibroblast cells has been appreciably good which is due to surface reorganisation and generation of synergistic hydrophilic-hydrophobic surface.
🔖
Cite This Article
KALLUKALAM, B. C., JAYABALAN, M., SANKAR, V. (2022). Injectable polyethylene glycol terminated poly(propylene fumarate)/acrylamide biodegradable materials for cardiac applications. Hacettepe Journal of Biology and Chemistry, Cilt: 36 - Sayı: 4, 283–290. https://ajindex.com/articles/529354
K.T. Shalumon and M. Jayabalan, Studies on biodegradation of crosslinked hydroxyl terminated poly(propylene fumarate) and formation of scaffold for orthopedic applications J. Mater. Sci. Mater. in Medicine, (online: 27 June 2008)
V.Thomas, M.Jayabalan, In vivo biocompatibility and biodurability of a novel virtually crosslinked high flex-life aliphatic polyurethane urea for fabrication of heart valve J. Biomed.Mat. Res.-Part A, (Online 22, Apr, 2008)
R.R.Nair and P.N.Gupta, Journal of Tissue Engineering Methods. 11 (1988) 211
Federal Regulations, Title 21,3 (April1, 2002) 325
W.R. Gombotz, W. Guanghui, T.A. Horbett and A.S. Hoffman, J. Biomed. Mater. Res. 25 (1991) 1547
E.A. Merril and E.W. Salzman, ASAIO J. 6 (1983) 60
P.M. Edwards, Biochem. Pharmacol., 24 (1975) 1277
M.J. Miller, D.E. Carter and I.G. Sipes, Toxicol. Appl. Pharmacol., 63 (1982) 36
L.H. Christensen, V.B. Breiting, A. Aasted, A. Jorgensen and I. Kebuladge, Plastic & Reconstructive Surgery. 111 (6) (2003) 1883. 11.N. Yoshimatsu, J. Kyoto Pref. Med. Univ., 64 (1958) 553
P.B. Van Wardem, A. Hogt, J. Bengeling, J. Feijen, A. Bantis, J.P. Detmers and W.G. Van Akan, Biomaterials., 8 (1987) 323
T. Koyano, N.Minoura, M.Nagura and K. Kobayashi, J. Biomed. Mater. Res., 39 (1998) 486.