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Journals / Hacettepe Journal of Biology and Chemistry / 2008 / Cilt: 36 - Sayı: 2

Bioengineering functional copolymers. VIII. stimuli-responsive boron-containing graft copolymers and their poly(ethylene imine) macrocomplexes and DNA conjugates

Erhan PİŞKİN
Zakir M. O. RZAEV
Dönsel ERDOĞAN
Mustafa TÜRK
Pages
83–98
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Obtained results, especially stimuli-responsive and very high transferable behavior allow use these boroncontaining graft copolymer systems as non-viral vectors in gene- and bioengineering processes and drug delivery systems, as well as in boron neutron capture therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:New boron-containing graft copolymers and their poly(ethylene imine) (PEI) macrocomplexes were synthesized by amidolysis of poly(N-isopropylacrylamide-co-maleic anhydride)s [poly(NIPA-co-MA)s] with ethanolamine ester of diphenylboronic acid (EAPB), and following complexation of graft copolymers with poly(ethylene imine) (PEI), respectively.
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Key Findings & Data:The structure, compositions and properties (stimuli-responsive, polyelectrolyte and thermal behavior) of synthesized copolymers were characterized by FTIR, 1H {13C} NMR and UV spectroscopy, viscometry, DSC and TGA analyses.
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Conclusion & Impact:Obtained results, especially stimuli-responsive and very high transferable behavior allow use these boroncontaining graft copolymer systems as non-viral vectors in gene- and bioengineering processes and drug delivery systems, as well as in boron neutron capture therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

New boron-containing graft copolymers and their poly(ethylene imine) (PEI) macrocomplexes were synthesized by amidolysis of poly(N-isopropylacrylamide-co-maleic anhydride)s [poly(NIPA-co-MA)s] with ethanolamine ester of diphenylboronic acid (EAPB), and following complexation of graft copolymers with poly(ethylene imine) (PEI), respectively. The structure, compositions and properties (stimuli-responsive, polyelectrolyte and thermal behavior) of synthesized copolymers were characterized by FTIR, 1H {13C} NMR and UV spectroscopy, viscometry, DSC and TGA analyses. It was shown that under given conditions (pH, temperature and grafting degree), these H-bonding macrocomplexes with hydrophobic diphenylborate side chain groups in aqueous solutions undergo a reversible cooperative conformational transition which is provided a promising possibility of adjusting the hydophobic–hydrophilic balance in the studied graft copolymer systems. Fluorescence measurements indicated that poly[(NIPA-co-MA)-g- EAPB]/PEI macrocomplex easily transferred to the HELA tumor cells, and showed low cytotoxicity against a normal cell line. Obtained results, especially stimuli-responsive and very high transferable behavior allow use these boroncontaining graft copolymer systems as non-viral vectors in gene- and bioengineering processes and drug delivery systems, as well as in boron neutron capture therapy.

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Cite This Article

PİŞKİN, E., RZAEV, Z. M. O., ERDOĞAN, D., TÜRK, M. (2022). Bioengineering functional copolymers. VIII. stimuli-responsive boron-containing graft copolymers and their poly(ethylene imine) macrocomplexes and DNA conjugates. Hacettepe Journal of Biology and Chemistry, Cilt: 36 - Sayı: 2, 83–98. https://ajindex.com/articles/529338

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