Journals / Hacettepe Journal of Biology and Chemistry / 2010 / Cilt: 38 - Sayı: 4

A study on combinatorial effects of various flavonoids for their antibacterial potential against clinically significant bacterial species

Pages
255–258
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results indicated the antibacterial potential of each flavonoid under mild-to-moderate concentrations; however, their effectiveness increased when both flavonoids were used in combination with various degree of concentrations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the present study, combinatorial effects of various flavonoids were evaluated against two Gram-positive and two Gram-negative bacteria of clinical relevance.
📊
Key Findings & Data:The results indicated the antibacterial potential of each flavonoid under mild-to-moderate concentrations; however, their effectiveness increased when both flavonoids were used in combination with various degree of concentrations.
💡
Conclusion & Impact:Flavonoids and their optimal combinations could be used as suitable alternatives towards finding new antimicrobial for the treatment of infectious diseases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the present study, combinatorial effects of various flavonoids were evaluated against two Gram-positive and two Gram-negative bacteria of clinical relevance. The results indicated the antibacterial potential of each flavonoid under mild-to-moderate concentrations; however, their effectiveness increased when both flavonoids were used in combination with various degree of concentrations. It has also been observed that Grampositive bacteria were found more susceptible than that of Gram-negative bacteria; the reasons can be attributed towards their cell wall structure. Flavonoids and their optimal combinations could be used as suitable alternatives towards finding new antimicrobial for the treatment of infectious diseases.

🔖

Cite This Article

GOYAL, P., AGGARWAL, B. K., GARG, S. (2022). A study on combinatorial effects of various flavonoids for their antibacterial potential against clinically significant bacterial species. Hacettepe Journal of Biology and Chemistry, Cilt: 38 - Sayı: 4, 255–258. https://ajindex.com/articles/529294

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Iwashina, T., The structure and distribution of the flavonoids in plants. J. Plant Res., 113, 287-299, 2000
  2. Chiang, L.C., Chiang, W., Liu, M.C., Lin, C.C., In vitro antiviral activities of Caeselpinia pulcherrima and its related flavonoids, J. Antimicrob. Chemother., 52, 194-198, 2003
  3. Zakay-Rones, Z., Thom, E., Wollant, T., Wadstein, J., Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J. Intern. Med. Res. 32, 132-140, 2004
  4. Cushnie, T.P.T., Lamb, A.J., Antimicrobial activity of flavonoids. Int. J. Antimicrob. Agents, 26(5), 343-356, 2005
  5. Inoue, T., Sugimoto, Y., Masuda, H., Kamei, C., Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L. Biol. Pharm. Bull., 25, 256-259, 2002
  6. Sawatzky, D., Willoughby, D., Colville-Nash, P., and Rossi, A., The involvement of the apoptosis-modulating proteins Erk 1/2, Bcl-xL, and Bax in the resolution of acute inflammation in vivo. Am. J. Pathol., 168, 33-41, 2006
  7. Lopez-Lazaro, M., Flavonoids as anticancer agents: structure-activity relationship study. Curr. Med. Chem. Anticancer Agents, 2(6), 691-714, 2002
  8. Pietta, P.G., Flavonoids as antioxidants. J. Nat. Prod., 63(7), 1035-1042, 2000
  9. Kim, Y.W., Hackett, J.C., Brueggemeier, R.W., Kim, Y.W., Hackett, J.C., Brueggemeier, R.W. Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones, J. Med. Chem., 47(16), 4032-4040, 2004
  10. National Committee for Clinical Laboratory Standards (NCCLS), Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Approved Standards M7-A4, 1997
  11. Olivella, M.S., Zarelli, V.E.P., Pappano, N.B., Debattista, N.B., A comparative study of bacteriostatic activity of synthetic hydroxylated flavonoids. Brazilian J. Microbiol., 32, 229-232, 2001
  12. Alvarez, M.A., Debattista, N.B. Pappano, N.B., Synergism of flavonoids with bacteriostatic action against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922, Biocell, 30, 39-42, 2006
  13. Alvarez, M.A., Debattista, N.B., Pappano, N.B., Antimicrobial activity and synergism of some substituted flavonoids, Folia Microbiol., 53, 23-28, 2004
  14. Goyal, P., Chauhan, A. and Kaushik, P., Assessment of Commiphora wightii (Arn.) Bhandari (Guggul) as potential source for antibacterial agent. J. Med. Med. Scie., 1(3), 71- 75, 2010.