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Journals / Hacettepe Journal of Biology and Chemistry / 2010 / Cilt: 38 - Sayı: 2

A modulator against gliotoxin-induced genotoxic damage: Pseudovernia furfuracea (L.) zoph.

Fatime GEYİKOĞLU
Suat ÇOLAK
Elanur AYDIN
Hasan TÜRKEZ
Ali ASLAN
Pages
119–123
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Our results indicated that, GTX caused statistically significant increases in SCE frequency as compared to control group.

📌 3 Key Takeaways

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Objective & Hypothesis:Gliotoxin (GTX) is one of the toxic, carcinogenic and mutagenic seconder metabolite which is produced by Gliocladium, Aspergillus and Penicillum species.
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Key Findings & Data:Therefore, in the present study, we assessed the genotoxic effects of GTX at different concentrations (50, 75 and 100 .ng/mL) and the role of P. furfuracea (5 and 10 |jg/mL) in GTX-treated cultures (n=2).
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Conclusion & Impact:Our results indicated that, GTX caused statistically significant increases in SCE frequency as compared to control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Gliotoxin (GTX) is one of the toxic, carcinogenic and mutagenic seconder metabolite which is produced by Gliocladium, Aspergillus and Penicillum species. Many in vivo and in vitro studies were carried out to minimize these harmfull effects of mycotoxins. To our best knowledge, the effects of the lichen, Pseudovernia furfuracea, against genetic damage induced by GTX on human lymphocytes were not evaluated. Therefore, in the present study, we assessed the genotoxic effects of GTX at different concentrations (50, 75 and 100 .ng/mL) and the role of P. furfuracea (5 and 10 |jg/mL) in GTX-treated cultures (n=2). The sister chromatid exchange (SCE) test was used to monitor the genetic damage. Our results indicated that, GTX caused statistically significant increases in SCE frequency as compared to control group. However, the SCE rates induced by different GTX concentrations were alleviated by the presence of P. furfuracea. As conclusion, the results of present study revealed for the first time that the lichen P. furfuracea provided increased resistance of DNA against GTX-induced genetic damage on human lymphocytes.

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Cite This Article

GEYİKOĞLU, F., ÇOLAK, S., AYDIN, E., TÜRKEZ, H., ASLAN, A. (2022). A modulator against gliotoxin-induced genotoxic damage: Pseudovernia furfuracea (L.) zoph.. Hacettepe Journal of Biology and Chemistry, Cilt: 38 - Sayı: 2, 119–123. https://ajindex.com/articles/529270

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References (1)

  1. Gulcin, I., Oktay, M., Kufrevioglu, O.I., Aslan, A., Determination of antioxidant activitiy of the lichen Cetraria islandica (L.) Ach, J. Ethnopharmacol. 79, 325, 2002. 2.Dülger, B., Gulcin, F. and Asian, A., Antimicrobial effect of lichen Cetraria islandica (L) Ach, Turk. J. Biol. 22, 111, 1998. 3.Huneck, S., The significance of lichens and their metabolites, Naturwissenschaften, 86, 559, 1999. 4.Halici, M., Odabasoglu, F., Süleyman, H., Cakir, A., Asian, A., Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats, Phytomedicine, 12, 656, 2005. 5.Odabasoglu, F., Cakir, A., Süleyman, H., Bayir, Y., Asian, A., Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats, J. Ethnopharmacol., 103, 59, 2006. 6.Richard, J.L., Debey M.C., Chermette, R., Pier, A.C., Hasegawa, A., Lund, A., Bratberg, A.M., Padhye, A.A. and Connole, M.D., Advances in veterinary mycology, J. Med. Vet. Mycol. 32, 169, 1994. 7.Scudamore, K.A., Livesey, C.Y., Occurrence and significance of mycotoxins in forage crops and silage: a review. J. Sci. Food. Agric. 77, 1, 1998. 8.Gardiner, D.M., Waring, P., Howlett, B.J., The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis, Microbiol. 151, 1021, 2005. 9.Pahl, H.L., Krauss, B., Schulze-Osthoff, K., Decker, T., Traenckner, E.B., Vogt, M., Myers, C., Parks, T., Warring, P., Muhlbacher, A., Czernilofsky, A.P. and Baeuerle, P.A., The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappa B, J. Exp. Med. 183, 1829, 1996. 10.Yamada, A., Kataoka, T., Nagai, K., The fungal metabolite gliotoxin: immunosuppressive activity on CTL mediated cytotoxicity, Immunol. Lett., 71, 27, 2000. 11.Kupfahl, C., Geginat, G., Hof, H., Gliotoxin-mediated suppression of innate and adaptive immune functions directed against,Listeria monocytogenes, Med. MycoL, 44, 591,2006. 12.Eichner, R.D., Salami, M.A., Wood, P.R., Mullbacher, A., Znt. J. Zmmunophnrmacol. 8, 789, 1986. 13.Lewis, R.E., Wiederhold, N.P., Chi, J., Han, X.Y., Komanduri, K.V., Kontoyiannis, D.P., Prince, R.A., Detection of gliotoxin in experimental and human aspergillosis, Infect. Immun., 73, 635, 2005. 14.Nieminen, S.M., Mâki-Paakkanen, J., Hirvonen, M.R., Roponen, M., von Wright, A., Genotoxicity of gliotoxin, a secondary metabolite of Aspergillus fumigatus, in a battery of short-term test