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Journals / Hacettepe Journal of Biology and Chemistry / 2015 / Cilt: 43 - Sayı: 2

Efficient and Green Synthesis of Mono- and Disubstituted 2,3-Dihydroquinazolin-4(1H)-Ones Using Squaric Acid as a New Organocatalyst in Water

Yeni Sulu Organokatalizör Skuarik Asit Varlığında Mono ve Disübstitüye 2,3-Dihidroksikuinazolin- 4(1H)-Ones’un Etkin ve Yeşil Sentezi

Fatemeh Ghanbari
Samad Khaksar
Sattar Arshadi
Pages
127–132
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These catalytic condensation reactions represent green chemical processes and the squaric acid organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A simple and facile synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-one derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and isatoic anhydride under reflux conditions in the presence of a squaric acid organocatalyst.
📊
Key Findings & Data:A simple and facile synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-one derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and isatoic anhydride under reflux conditions in the presence of a squaric acid organocatalyst.
💡
Conclusion & Impact:These catalytic condensation reactions represent green chemical processes and the squaric acid organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A simple and facile synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-one derivatives has been successfully developed by treatment of aldehydes, ammonium acetate, and isatoic anhydride under reflux conditions in the presence of a squaric acid organocatalyst. These catalytic condensation reactions represent green chemical processes and the squaric acid organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction.

Özet

A ldehitler, amonyum asetat ve izotaktik anhidrit muameleleriyle skuarik asit organokatalizörü varlığında geri soğutucu altında, mono ve disübstitiye 2,3-dihidrokinazolin -4(1H) türevlerinin sentezi başarılı bir şekilde gerçekleştirilmiştir. Bu katalitik yoğuşma tepkimeleri yeşil kimya süreçlerini kapsamaktadır. Skuarik asit organokatalizörü havada kararlı, uygun maliyetli ve kullanımı kolaydır. Ayrıca tepkime ortamından kolaylıkla uzaklaştırılabilir.

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Cite This Article

Ghanbari, F., Khaksar, S., Arshadi, S. (2022). Efficient and Green Synthesis of Mono- and Disubstituted 2,3-Dihydroquinazolin-4(1H)-Ones Using Squaric Acid as a New Organocatalyst in Water. Hacettepe Journal of Biology and Chemistry, Cilt: 43 - Sayı: 2, 127–132. https://ajindex.com/articles/529154

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