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Journals / Hacettepe Journal of Biology and Chemistry / 2017 / Cilt: 45 - Sayı: 2

Synthesis and Biological Evaluation of New 2-Ethoxy-6-[(4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl)iminomethyl]phenyl 4-nitro-benzoate Derivatives

Yeni 2-Etoksi-6-[(4,5-dihidro-1H-1,2,4-triazol-5-on-4-il) iminometil]fenil 4-nitrobenzoat Türevlerinin Sentezi ve Biyolojik Değerlendirmesi

Özlem GÜRSOY KOL
Murat BEYTUR
Önder ALBAYRAK
Faruk KARDAŞ
Haydar YÜKSEK
Muzaffer ALKAN
Sevda MANAP
Pages
153–161
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In addition, these new compounds were screened for their antimicrobial activities.

📌 3 Key Takeaways

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Objective & Hypothesis:In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-2-(4- nitrobenzoxy)-benzaldehyde (2) to afford 2-ethoxy-6-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) iminomethyl]phenyl 4-nitrobenzoates (3).
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Key Findings & Data:The structures of new nine compounds were established from the elemental analyses, IR, 1 H NMR and 13C NMR spectral data.
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Conclusion & Impact:In addition, these new compounds were screened for their antimicrobial activities.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-2-(4- nitrobenzoxy)-benzaldehyde (2) to afford 2-ethoxy-6-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) iminomethyl]phenyl 4-nitrobenzoates (3). The structures of new nine compounds were established from the elemental analyses, IR, 1 H NMR and 13C NMR spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. In addition, these new compounds were screened for their antimicrobial activities.

Özet

Bu çalışmada, 3-alkil(aril)-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on (1) bileşikleri 3-etoksi-2- (4-nitrobenzoksi)-benzaldehid (2) ile reaksiyona sokularak 2-etoksi-6-[(3-alkil/aril-4,5-dihidro- 1H-1,2,4- triazol-5-on-4-il)iminometil]fenil 4-nitrobenzoat (3) bileşikleri elde edildi. Yeni dokuz adet bileşiğin yapısı elementel analiz ve IR, 1 H NMR ve 13C NMR spektrum verileri ile aydınlatıldı. Sentezlenen bileşiklerin in vitro potansiyel antioksidan aktiviteleri üç farklı yöntemle analiz edildi. Ayrıca, yeni bileşiklerin antimikrobiyal aktiviteleri incelendi.

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Cite This Article

KOL, Ö. G., BEYTUR, M., ALBAYRAK, Ö., KARDAŞ, F., YÜKSEK, H., ALKAN, M., MANAP, S. (2022). Synthesis and Biological Evaluation of New 2-Ethoxy-6-[(4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl)iminomethyl]phenyl 4-nitro-benzoate Derivatives. Hacettepe Journal of Biology and Chemistry, Cilt: 45 - Sayı: 2, 153–161. https://ajindex.com/articles/529115

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