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Journals / Hacettepe Journal of Biology and Chemistry / 2019 / Cilt: 47 - Sayı: 1

Preparation of Poly(DL-Lactide/ε-Caprolactone)–β-TCP Composites for Bone Tissue Repair

Kemik Dokusu Onarımı için Poli(DL-Laktat/ε-Kaprolakton)–β-TCP Kompozitlerin Hazırlanması

Erhan BİSKİN
Hasret Tolga SİRİN
Ebru AKDOGAN
Pages
133–141
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Degradation rate of the composites decreased as the percentage of β-TCP in the structure increased.

📌 3 Key Takeaways

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Objective & Hypothesis:Poly-D,L-Lactide/ε-caprolactone (PDLLA-ε-CL) and β-tri-calcium phosphate (β-TCP) composites were prepared as analternative for injectable filling material in bone tissue repair. β-TCP was synthesized by a wet precipitation method andcharacterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometer (XRD), Zeta-SIZER and Brunauer–Emmett–Teller (BET) analyser.
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Key Findings & Data:PDLLA-ε-CL copolymer was synthesized under nitrogen (N2) atmosphere using ring-openingpolymerization in the presence of stannous octoate as a catalyst.
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Conclusion & Impact:Degradation rate of the composites decreased as the percentage of β-TCP in the structure increased.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Poly-D,L-Lactide/ε-caprolactone (PDLLA-ε-CL) and β-tri-calcium phosphate (β-TCP) composites were prepared as analternative for injectable filling material in bone tissue repair. β-TCP was synthesized by a wet precipitation method andcharacterised using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometer (XRD), Zeta-SIZER and Brunauer–Emmett–Teller (BET) analyser. PDLLA-ε-CL copolymer was synthesized under nitrogen (N2) atmosphere using ring-openingpolymerization in the presence of stannous octoate as a catalyst. The chemical structures of copolymers were determinedby FTIR and Proton Nuclear Magnetic Resonance (1H-NMR) analysis. The average molecular weights of copolymers wereidentified by Gel Permeation Chromatography (GPC). (PDLLA-ε-CL)-β-TCP composites were then prepared by loadingdiffering amounts of β-TCP to the copolymer phase. The resulting composites were easily shaped by hand. The degradationprofiles of the composites were determined by monitoring the changes in the molecular weight of the co-polymers overa period of 42 days. Degradation rate of the composites decreased as the percentage of β-TCP in the structure increased.

Özet

Poly-D,L-Laktat/ε-kaprolakton (PDLLA-ε-CL) ve β-tri-kalsiyum fosfat (β-TCP) kompozitleri, alternatif bir biyobozunur enjekte edilebilir dolgu malzemesi olarak geliştirilmiştir. Bu amaçla β-TCP, çöktürme yöntemi ile sentezlenmiştir ve karekterizasyonu Fourier Dönüşüm Kızılötesi Spektroskopi (FTIR), X-Işını Defraktometresi (XRD), Zeta-SIZER ve BrunauerEmmett-Teller (BET) kullanılarak yapılmıştır. PDLLA-ε-CL kopolimeri, katalizör olarak kalay oktoat kullanılarak halka açılım polimerizasyonu ile azot (N2) atmosferi altında sentezlenmiştir. Kopolimerlerin karakterizasyonu FTIR ve Proton Nükleer Manyetik Rezonans (H-NMR) analizi ile yapılmıştr. Ortalama moleküler ağırlığı, Jel Geçirgenlik Kromatografisi (GPC) ile hesaplanmıştır. (PDLLA-ε-CL)-β-TCP kompozitleri, kopolimere farklı miktarlarda β-TCP yüklenerek hazırlanmıştır. Elde edilen kompozitler kolayca elle şekillendirilebilmektedir. Kompozitlerin bozunma profilleri, 42 gün boyunca kopolimerlerin moleküler ağırlığındaki değişimlerin izlenmesi ile belirlenmiştir. β-TCP oranı arttıkça kompozitlerin bozunma oranının azaldığı gözlenmiştir.

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Cite This Article

BİSKİN, E., SİRİN, H. T., AKDOGAN, E. (2022). Preparation of Poly(DL-Lactide/ε-Caprolactone)–β-TCP Composites for Bone Tissue Repair. Hacettepe Journal of Biology and Chemistry, Cilt: 47 - Sayı: 1, 133–141. https://ajindex.com/articles/529028

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