Antimicrobial activity of the compounds was tested against two Gr (+) bacteria (S. aureus, E. faecalis), two Gr (-) bacteria (P. aeruginosa, E. coli), and three yeast-like fungi (C. albicans, C. krusei, C. parapsilosis) by modified agar dilution method.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, four new oxime ether derivatives were synthesized and their antimicrobial activities were evaluated.
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Key Findings & Data:The structures of synthesized compounds were confirmed by their IR, 1H-NMR, and HRMS spectra.
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Conclusion & Impact:Antimicrobial activity of the compounds was tested against two Gr (+) bacteria (S. aureus, E. faecalis), two Gr (-) bacteria (P. aeruginosa, E. coli), and three yeast-like fungi (C. albicans, C. krusei, C. parapsilosis) by modified agar dilution method.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
In this study, four new oxime ether derivatives were synthesized and their antimicrobial activities were evaluated. At the same time, a comparison of the efficiency of the conventional method of synthesis with the microwave method was inves-tigated. The structures of synthesized compounds were confirmed by their IR, 1H-NMR, and HRMS spectra. Antimicrobial activity of the compounds was tested against two Gr (+) bacteria (S. aureus, E. faecalis), two Gr (-) bacteria (P. aeruginosa, E. coli), and three yeast-like fungi (C. albicans, C. krusei, C. parapsilosis) by modified agar dilution method.
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Cite This Article
SELLİTEPE, H. E., ÖZDEMİR, Z., ALAGÖZ, M. A., DOĞAN, İ. S., KART, D. (2022). Conventional and Microwave Assisted Synthesis of New Triazole Derivatives and Evaluation of Their Antimicrobial Activities. Hacettepe Journal of Biology and Chemistry, Cilt: 47 - Sayı: 3, 277–286. https://ajindex.com/articles/529025
A.S. Hassan, D.M. Masoud, F.M. Sroor, A.A. Askar, Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents, Med. Chem. Res., 26 (2017) 2909-2919
I. Roca, M. Akova, F. Baquero, J. Carlet, M. Cavaleri, S. Coenen, J. Cohen, D. Findlay, I. Gyssens, O.E. Heure, G. Kahlmeter, The global threat of antimicrobial resistance: science for intervention, New Microbes New Infect., 6 (2015) 22-29
M.A. Abdelrahman, I. Salama, M.S. Gomaa, M.M. Elaasser, M.M. Abdel-Aziz, D.H. Soliman, Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents, Eur. J. Med. Chem., 138 (2017) 698-714
S. Silva, M. Negri, M. Henriques, R. Oliveira, D.W. Williams, J. Azeredo, Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance, FEMS Microbiol. Rev., 36/2 (2012) 288-305
M. Janeczko, O.M. Demchuk, D. Strzelecka, K. Kubinski, M. Masłyk, New family of antimicrobial agents derived from 1,4-naphthoquinone., Eur. J. Med. Chem., 124 (2016) 1019-1025
S. Concilio, L. Sessa, A.M. Petrone, A. Porta, R. Diana, P. Iannelli, S. Piotto, Structure Modification of an Active Azo-Compound as a Route to New Antimicrobial Compounds, Molecules, 22 (2017) 875
A. Karakurt, M.D. Aytemir, J.P. Stables, M. Özalp, F.B. Kaynak, S. Özbey, S. Dalkara, Synthesis of some oxime ether derivatives of 1-(2-naphthyl)-2-(1,2,4-triazol-1-yl)ethanone and their anticonvulsant and antimicrobial activities, Arch. Pharm. (Weinheim, Germany), 339 (2006) 513-520
S. Kaping, I. Boiss, L.I. Singha, P. Helissey, J.N. Vishwakarma, A facile, regioselective synthesis of novel 3-(N-phenylcarboxamide)pyrazolo[1,5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their antibacterial activities, Mol. Divers., 20 (2016) 379–390
S. Deshmukh, K. Dingore, V. Gaikwad, M. Jachak, An efficient synthesis of pyrazolo[1,5-a]pyrimidines and evaluation of their antimicrobial activity, J Chem. Sci., 128 (2016) 1459–1468
J. Zhang, J.F. Peng, T. Wang, P. Wang, Z.T. Zhang, Synthesis, crystal structure, characterization and antifungal activity of pyrazolo[1,5-a]pyrimidines derivatives, J. Mol. Struct., 1120 (2016) 228–233
A.N. Ambhore, R.D. Kamble, P.P. Mogle, S.V. Hese, S.N. Kadam, M.J. Hebade, S.S. Kamble, R.N. Gacche, B.S. Dawane1, An Efficient One-pot Synthesis of some New Pyrazol