SavedAdd your journal

Journals / Hacettepe Journal of Biology and Chemistry / 2021 / Cilt: 49 - Sayı: 1

DNA/HSA Interactions and Anticancer Activity of a Palladium(II) SaccharinateComplex Bearing Ethyldiphenylphosphine

Etildifenilfosfin İçeren Bir Paladyum(II) Sakkarinat Kompleksinin DNA/HSA ile Etkileşimleri ve Antikanser Aktivitesi

Ceyda İÇSEL
Pages
107–116
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The binding interactions of cis-[Pd(sac)2(PPh2Et)2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies.
📊
Key Findings & Data:The Pd(II) complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA.
💡
Conclusion & Impact:The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The binding interactions of cis-[Pd(sac)2(PPh2Et)2] with DNA and HSA were comprehensively studied by a number of experimental methods and molecular docking studies. The Pd(II) complex bound to AT-rich sites in the major groove of DNA, and interacted with the hydrophobic cavity of the subdomain IIA of HSA. These experimental findings were supported by molecular docking studies. The Pd(II) complex had shown strong cytotoxic activity against different cancer cell lines and it also had selectivity especially for MCF-7 breast cancer cells higher than cisplatin.

Özet

Cis-[Pd(sac)2(PPh2Et)2] kompleksinin DNA ve HSA bağlanma etkileşimleri bir seri deneysel yöntem ve moleküler dokingile kapsamlı bir şekilde çalışıldı. Pd(II) kompleksi DNA’nın majör oluğundaki AT’ce zengin konumlara bağlandı ve HSA’nınIIA alt bölgesindeki hidrofobik boşluk ile etkileşti. Bu deneysel bulgular moleküler doking çalışmaları ile desteklendi. Pd(II)kompleksi farklı kanser türlerine karşı güçlü sitotoksik aktivite gösterdi. Özellikle MCF-7 meme kanser hücreleri içinsisplatinden daha yüksek seçiciliğe sahip oldu.

🔖

Cite This Article

İÇSEL, C. (2022). DNA/HSA Interactions and Anticancer Activity of a Palladium(II) SaccharinateComplex Bearing Ethyldiphenylphosphine. Hacettepe Journal of Biology and Chemistry, Cilt: 49 - Sayı: 1, 107–116. https://ajindex.com/articles/528942

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. A. Garoufis, S.K. Hadjikakou, N. Hadjiliadis, Palladium coordination compounds as anti-viral, anti-fungal, anti- microbial and anti-tumor agents, Coord. Chem. Rev., 253 (2009) 1384-1397
  2. Md N. Alam, F. Huq, Comprehensive review on tumour active palladium compounds and structure–activity relationships, Coord. Chem. Rev., 316 (2016) 36-67
  3. E.Z. Jahromi, A. Divsalar, A.A. Saboury, S. Khaleghizadeh, H. Mansouri-Torshizi, I. Kostova, Palladium complexes: new candidates for anti-cancer drugs, J. Iran Chem. Soc., 13 (2016) 967-989
  4. T. Lazarevic, A. Rilak, Z.D. Bugarcic, Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives, Eur. J. Med. Chem., 142 (2017) 8-31
  5. E.J. Baran, V.T. Yilmaz, Metal complexes of saccharin, Coord. Chem. Rev., 250 (2006) 1980-1999
  6. M. Cavicchioli, A.C. Massabni, E.E. Castellano, L.P.B. Sabeh, C.M. Costa-Neto, Synthesis and X-ray structure of the dinuclear platinum(II) complex with saccharin {K[Pt(sac)3(H2O)]·H2O}2: studies on its antiproliferative activity in aqueous solution, Inorg. Chim. Acta, 360 (2007) 3055-3060
  7. E. Ulukaya, F. Ari, K. Dimas, M. Sarimahmut, E. Guney, N. Sakellaridis, V.T. Yilmaz, Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small Cell lung cancer cells in vitro, J. Cancer Res. Clin. Oncol., 137 (2011)1425-1434
  8. E. Ulukaya, F. Ari, K. Dimas, E.I. Ikitimur, E. Guney, V.T. Yilmaz, Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo, Eur. J. Med. Chem., 46 (2011) 4957-4963
  9. E. Guney, V.T. Yilmaz, F. Ari, O. Buyukgungor, E. Ulukaya, Synthesis, characterization, structures and cytotoxic activity of palladium(II) and platinum(II) complexes containing bis(2- pyridylmethyl)amine and saccharinate, Polyhedron, 30 (2011) 114-122
  10. F. Ari, N. Aztopal, C. Icsel, V.T. Yilmaz, E. Guney, O. Buyukgungor, E. Ulukaya, Synthesis, structural characterization and cell death-inducing effect of novel palladium(II) and platinum(II) saccharinate complexes with 2-(hydroxymethyl)pyridine and 2-(2-hydroxyethyl)pyridine on cancer cells in vitro, Bioorg. Med. Chem., 21 (2013) 6427-6434
  11. S.A. Al-Jibori, G.H. Al-Jibori, L.J. Al-Hayaly, C. Wagner, H. Schmidt, S. Timur, F.B. Barlas, E. Subasi, S. Ghosh, G. Hogarth, Combining anti-cancer drugs with artificial sweeteners: synthesis and anti-cancer activity of saccharinate (sac) and thiosaccharinate (