Journals / Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research) / 2006 / Cilt: 30 - Sayı: 3

Pöröz hidroksiapatit ile hidroksiapatit/kollajen kombinasyonunun histolojik etkilerinin erken dönem kemik İyileşmesinde karşılaştırılması

The comparison of histological effects of porous hydroxyapatite and hydroxyapatite/collagen combination on short term bone healing

Pages
67–73
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The results of our experimental study showed all of the tested materials were biocompatible with the soft and hard tissues and aggravated the bone heal-

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Synthetic hydroxyapatite (HA) particulates for the surgical augmentation of edentulous alveolar ridge and other bone deficiencies have shown some limitations with respect to the retention of the shape and distribution of the particulate after surgical placement.
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Key Findings & Data:Material and Methods: 30 Guinea pigs from both sexes were selected and three experimental defects were created on the corpus mandible and filled with hydroxyapatite and combination of hydroxyapatitecollagen matrix.
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Conclusion & Impact:Results: The results of our experimental study showed all of the tested materials were biocompatible with the soft and hard tissues and aggravated the bone heal-
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Synthetic hydroxyapatite (HA) particulates for the surgical augmentation of edentulous alveolar ridge and other bone deficiencies have shown some limitations with respect to the retention of the shape and distribution of the particulate after surgical placement. Organic substances such as collagen, when mixed with the particulate, can offer the opportunity to retain the particulate at the surgical site; improve the placement procedures through the relative ease of manipulation; and influence tissue ingrowth and development characteristics by controlling the interparticulate spaces with a biocompatible material of controlled biodegradation properties. The purpose of the present study is to compare the effects of porous particulate hydroxyapatite with combination of HA-collagen matrix on short term bone healing histopathologically. Material and Methods: 30 Guinea pigs from both sexes were selected and three experimental defects were created on the corpus mandible and filled with hydroxyapatite and combination of hydroxyapatitecollagen matrix. One defect was left empty as control group. The histological examinations were performed on 7th, 14th and 21st days. Results: The results of our experimental study showed all of the tested materials were biocompatible with the soft and hard tissues and aggravated the bone heal-

Özet

Amaç: Alveolar kret yüksekliğinin arttırılması veya kemik defektlerinin kapatılması amacıyla kullanılan sentetik hidroksiapatit partiküllerinin cerrahi olarak bölgeye uygulanması veya bölgedeki kalıcığı bir takım sıkıntılar sergileyebilir. Ancak, kollajen gibi organik bir materyalin hidroksiapatit partikülleri ile kombine olarak kullanılması, yapılacak cerrahi işleme uygulama kolaylığı, materyalin bölgedeki kalıcılığı ve partiküller arası boşluğu doldurarak doku gelişimi için iyi bir çatı oluşturması gibi özellikler sağlayabilir. Yapılan bu çalışmanın amacı pöröz hidroksiapatit partikülleri ile hidroksiapatit/kollajen kombinasyonunun erken dönem kemik iyileşmesindeki histopatolojik etkilerinin karşılaştırılmasıdır. Gereç ve Yöntem: Her iki cinsten 30 kobayın corpus mandibularında deneysel defektler oluşturularak, bu bölgeler hidroksiapatit partikülleri ve hidroksiapatit/kollajen matriks kombinasyonu ile doldurulmuştur. Oluşturulan diğer bir defekt bölgesi ise kontrol grubunu teşkil edecek şekilde boş bırakılmıştır. Histopatolojik incelemeler 7., 14. ve 21. günlerde yapılmıştır. Bulgular: Çalışmamızda test edilen her iki materyalinde yumuşak ve sert dokularla biyolojik olarak uyumlu olduğu ve kemik iyileşme kapasitesini attırdığı gözlenmiştir. İki deney grubu karşılaştırıldığında, kemik iyileşme fazında hidroksiapatit/kollajen kombinasyonunun daha etkili olduğu belirlenmiştir.

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Cite This Article

COŞKUN, B., BULUT, Ö. E., TAŞMAN, U., DAĞDEVİREN, A., KÖSEOĞLU, O. T. (2022). Pöröz hidroksiapatit ile hidroksiapatit/kollajen kombinasyonunun histolojik etkilerinin erken dönem kemik İyileşmesinde karşılaştırılması. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), Cilt: 30 - Sayı: 3, 67–73. https://ajindex.com/articles/528488

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