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Journals / Gümüşhane Üniversitesi Fen Bilimleri Dergisi / 2021 / Cilt: 11 - Sayı: 1

Determination of ın vivo chronic effects of astaxanthin in different strains of drosophila melanogaster

Drosophila melanogaster’in farklı soylarında astaksantin’in in vivo kronik etkilerinin belirlenmesi

Handan UYSAL
Hatice ÇELİK
Pages
135–146
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When the results of the control and application groups of the ASTA terpene were compared, it was observed that the average life span decreased in both female and male populations depending on the dose-time interaction (p

📌 3 Key Takeaways

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Objective & Hypothesis:Astaxanthine (ASTA) terpene, a red pigment found in algae known as rhodopite, is a tetraterpene.
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Key Findings & Data:For this purpose, adult female and male individuals were chronically fed on media containing different doses of the ASTA (25, 50, 100 and 200 ppm).
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Conclusion & Impact:When the results of the control and application groups of the ASTA terpene were compared, it was observed that the average life span decreased in both female and male populations depending on the dose-time interaction (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Genotoksik etki · Karotenoid · Ömür uzunluğu

Abstract

Astaxanthine (ASTA) terpene, a red pigment found in algae known as rhodopite, is a tetraterpene. In this study, possible toxic and genotoxic effects of the ASTA were investigated depending on the dose-time interaction. The toxic effect of the ASTA was determined by in vivo longevity test in Oregon-R wild strain of Drosophila melanogaster. For this purpose, adult female and male individuals were chronically fed on media containing different doses of the ASTA (25, 50, 100 and 200 ppm). While the average life span in the control group is 49.07±1.92 days in females, it is 51.01±2.12 days in males. These values are 32.06±1.50 and 27.06±1.18 days in females in the lowest and highest ASTA application groups (25-200 ppm), 32.45±1.48 and 23.52±0.92 in males, respectively. When the results of the control and application groups of the ASTA terpene were compared, it was observed that the average life span decreased in both female and male populations depending on the dose-time interaction (p

Özet

Rodofit olarak bilinen alglerde bulunan ve kırmızı renkli bir pigment olan astaksantin (ASTA) terpeni bir tetraterpendir. Çalışmada ASTA’nın doz-süre etkileşimine bağlı olarak olası toksik ve genotoksik etkileri araştırılmıştır. ASTA’nın toksik etkisi, Drosophila melanogaster’in Oregon-R yabanıl soyunda in vivo ömür uzunluğu testi ile belirlenmiştir. Bu amaçla ergin dişi ve erkek bireyler farklı dozlarda ASTA içeren (25, 50, 100 ve 200 ppm) besiyerinde kronik olarak beslenmiştir. Kontrol grubunda ortalama ömür uzunluğu dişilerde 49.07±1.92 gün iken erkeklerde 51.01±2.12 gündür. Bu değerler en düşük ve en yüksek ASTA uygulama gruplarında (25-200 ppm) dişilerde sırasıyla 32.06±1.50 ve 27.06±1.18 gün, erkeklerde de 32.45±1.48 ve 23.52±0.92 gün olarak bulunmuştur. ASTA’nın kontrol ve uygulama gruplarına ait sonuçlar birbiriyle karşılaştırıldığı zaman hem dişi hem de erkek popülasyonunda ortalama ömür uzunluğunun doz-süre etkileşimine bağlı olarak kısaldığı gözlenmiştir (p

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Cite This Article

UYSAL, H., ÇELİK, H. (2022). Determination of ın vivo chronic effects of astaxanthin in different strains of drosophila melanogaster. Gümüşhane Üniversitesi Fen Bilimleri Dergisi, Cilt: 11 - Sayı: 1, 135–146. https://ajindex.com/articles/526843

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References (16)

  1. Al-Zubairi, A.S., Abdul, A.B. ve Syam, M.M. (2010). Evaluation of the genotoxicity of zerumbone in cultured human peripheral blood lymphocytes. Toxicology In Vitro, 24, 707-712.
  2. Arıca, Ş.Ç. (2017). Yaşlanma ve alglerin anti-gerontolojik etkileri. Ege Journal of Fisheries and Aquatic Sciences, 34(4), 469-474.
  3. Aslan, N. (2005). Kekik tarımı ve kullanım alanları. Lisans Bitirme Tezi, Ziraat Fakültesi Tarla Bitkileri Bölümü, Dicle Üniversitesi,
  4. Diyarbakır. Azqueta, A. ve Collins, A. R. (2012). Carotenoids and DNA damage. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 733(1-2), 4-13.
  5. Azirak, S. ve Rencüzoğulları, E. (2008). The in vivo genotoxic effects of carvacrol and thymol in rat bone marrow cells. Environmental Toxicology, 23(6), 728-735.
  6. Büyükleyla, M. ve Rencüzoğulları, E. (2009). The effects of thymol on sister chromatid exchange, chromosome aberration and micronucleus in human lymphocytes. Ecotoxicology and Enviromental Safety, 72(3), 943-947.
  7. Calixto, J.B. (2000). Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Brazilian Journal of Medical and Biological Research, 33(2), 179-189.
  8. Chang, H.T., Chou, C.T., Liang, W.Z., Lu, T., Kuo, D.H., Shieh, P., Ho, C.M. ve Jan, C.R. (2014). Effects of thymol on Ca²⁺ homeostasis and apoptosis in MDCK renal tubular cells. Chinese Journal of Physiology, 57(2), 90-98.
  9. Cho, K.S., Lim, Y.R., Lee, K., Lee, J., Lee, J.H. ve Lee, I.S. (2017). Terpenes from forests and human health. Toxicological Research, 33(2), 97-106.
  10. Clark, R.L. (2009). Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester. Reproductive Toxicology, 28, 285-296.
  11. Clarkson, P.M. ve Thompson, H.S. (2000). Antioxidants: what role do they play in physical activity and health?. The American Journal of Clinical Nutrition, 72(2), 637-646.
  12. Çelik, H., Kızılet, H., Özdal, M., Gülmez, O., Algur, Ö.F. ve Uysal, H. (2018). Lactarius indigo mantarında bulunan ve ömür uzunluğunu inhibe eden guazilen’e karşı Pleurotus sajor-caju ve Pleurotus osteratus mantarları. International Eurasian Conference on Biological and Chemical Sciences 26-27
  13. April, Ankara,
  14. Türkiye. Çelik, H. ve Uysal H. (2019). Stimulation of longevity toxicity based on chronic application of terpenes. International Eurasian Conference on Biological and Chemical Sciences 28-29
  15. June, Ankara,
  16. Türkiye. Davinelli, S., Nielsen, M.E ve Scapagnini, G. (2018). Asta