SavedAdd your journal

Journals / Göztepe Tıp Dergisi / 2003 / Cilt: 18 - Sayı: 3

The occurrence of acute insulin response changes in patients with rheumatoid arthritis

Romatoid artritli hastalarda akut insülin cevabı değişiklikleri

Cihan TOP
Özcan KESKİN
M. Emin ÖNDE
Altuğ TUNCEL
Pages
166–167
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The AIR values were significantly lower in all patients with rheumatoid artritis than in control subjects (35.8±17 vs. 85.2±17.9 (IU/ml, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Insulin resistance is a common pathologic state in which target cells fail to respond to ordinary levels of circulating insulin.
📊
Key Findings & Data:The aim of this study was to assess the occurence of acute insulin response changes in patients with rheumatoid arthritis. 36 subjects (22 women and 14 men, aged 51.5±17.1 years; range 21-80, BMI 27.1±5.0 kg/m2) with varying degrees of disease activity and 20 healthy controls were studied.
💡
Conclusion & Impact:The AIR values were significantly lower in all patients with rheumatoid artritis than in control subjects (35.8±17 vs. 85.2±17.9 (IU/ml, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Insulin resistance is a common pathologic state in which target cells fail to respond to ordinary levels of circulating insulin. The aim of this study was to assess the occurence of acute insulin response changes in patients with rheumatoid arthritis. 36 subjects (22 women and 14 men, aged 51.5±17.1 years; range 21-80, BMI 27.1±5.0 kg/m2) with varying degrees of disease activity and 20 healthy controls were studied. After a 12-h overnight fast, all subjects underwent a diagnostic protocol including the estimation of Acute Insulin Response (AIR) changes that was calculated by datas obtained from intravenous glucose tolerance test. The AIR values were significantly lower in all patients with rheumatoid artritis than in control subjects (35.8±17 vs. 85.2±17.9 (IU/ml, p

Özet

İnsülin direnci, dolaşımdaki normal sınırlardaki insüline hedef hücre cevabının bozulduğu patolojik bir durumdur. Bu çalışmanın amacı; romatoid artritli hastalarda akut insülin cevabı değişiklikleri gelişimini ortaya koymaktır. Çalışmaya değişik derecelerde hastalık aktivitesine sahip 36 romatoid artritli olgu (22 kadın ve 14 erkek, 51.5±17.1 yaşlarında; 21-80 yaş arası, vücut kitle indeksi 27.1±5.0 kg/m2 olan) ve 20 sağlıklı kontrol dahil edilmiştir. Tüm olgulara, 12 saatlik açlığı takiben, IVGTT'den elde edilen verilerle belirlenen AIR (akut insülin cevabı) ölçümünden oluşan tanısal protokol uygulandı.Romatoid artritli hastalarda kontrollere oranla, AIR anlamlı derecede daha düşüktü (35.8±17 vs. 85.2±17.9 (IU/ml, p

🔖

Cite This Article

TOP, C., KESKİN, Ö., ÖNDE, M. E., TUNCEL, A. (2022). The occurrence of acute insulin response changes in patients with rheumatoid arthritis. Göztepe Tıp Dergisi, Cilt: 18 - Sayı: 3, 166–167. https://ajindex.com/articles/526464

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Gordon DA, Hastings DE: Rheumatoid Arthritis. Clinical Features of Early, Progressive and Late Disease. Rheumatology, Second Editioa Klippel, J.H., Dieppe, P.A. London Philadelphia St. Louis Sydney Tokyo, 5(3): 1-3,4, 1998
  2. Mac Gregor AJ, Silman AJ: Rheumatoid Arthritis, Classification and Epidemiology. Rheumatology, Second Edition. Klippel J.H., Dieppe.P.A. London Philadelphia St. Louis Sydney Tokyo, 5:2.1 -2.6,1998
  3. Matteson EJ, Cohen MD, Conn DL: Rheumatoid Arthritis, Clinical Features and Systemic Involvment. Rheumatology, Second Edition. Klippel J.H., Dieppe P.A. London Philadelphia St. Louis Sydney Tokyo, 5:4.1-4.8, 1998
  4. Claussen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pederson (): Insulin Sensitivity Index, Acute Insulin Response, and Glucose Effectiveness in a Population-Based Sample of 380 Young Healthy Caucasians. Anaysis of The Impact of Gender, Body Fat, Physical Fitness, and Life-Style Factors. J Clin 98:1195-1209, 1996
  5. Cline GW, Petersen KF, Krssak M, Shen J, et al: Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes. N Engl J Med 341:240-246, 1999
  6. Haffner SIM, Howard G, Mayer E, Bergman RN, Savage P.I, Rewers M, Mykanen L, Karter AJ, Hamman R, Saad MF: Iasulin Sensitivity and Acute Insulin Response in Africans-Americans, Non-Hispanic Whites, and Hispanics with NIDDM: The Insulin Resistance Atherosclerosis Study. Diabetes 46:63-69,1997
  7. Mykanen L, Haffner SM, Hales CN, Ronnemaa T, Laakso M: The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Nonnoglisemic Subjects. Diabetes 46(12):1990-1995,1997
  8. Arnett FC, Edworthy SM, Bloch DA, et ah The American Rheumatism association 1987 Revised Criteria for The Classification of Rheumatoid Arthritis. J Rheumatology 31:315-324,1988
  9. Matthews DR, Hosker JP, Turner RC: Homeostasis Model Assesment: Insulin Resistance and [3-cell Function from Fasting Plasma Glucose and Insulin Concentratioas in Man. Diabetologia 28:412-419,1985.