Journals / Göztepe Tıp Dergisi / 2012 / Cilt: 27 - Sayı: 4

Effect of magnesium sulphate infusion on blood rheology during gynecologic oncology surgery

Jinekolojik kanser ameliyatlarında magnezyum sülfat uygulamasının kan reolojisi üzerine etkileri

Pages
174–181
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: IV administration of Mg sulphate in conventional dosage had no effect on blood viscosity, plasma viscosity, red blood cell deformability.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study tested magnesium sulphate infusion to improve blood rheology during and after gynecologic oncology surgery.
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Key Findings & Data:The magnesium group received an inital dose of 30 mg/kg followed by 10 mg/ kg/h over 20h.
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Conclusion & Impact:Conclusion: IV administration of Mg sulphate in conventional dosage had no effect on blood viscosity, plasma viscosity, red blood cell deformability.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study tested magnesium sulphate infusion to improve blood rheology during and after gynecologic oncology surgery. Materials and Methods: In a randomized, single blinded study, patients were assigned to two groups. The magnesium group received an inital dose of 30 mg/kg followed by 10 mg/ kg/h over 20h. The control group received placebo. Blood samples were obtained before magnesium administration, 90 minutes and 24 hours following initial magnesium administration. Blood viscosity, plasma viscosity, red blood cell deformability, Mg, total protein, albumin, fibrinogen and Htc were investigated. Results: There were no significant differences between two groups in blood viscosity, plasma viscosity, and red blood cell deformability. Blood viscosity levels decreased in both groups. Plasma viscosity levels unchanged in both groups. Red blood cell deformability decreased in both groups. Conclusion: IV administration of Mg sulphate in conventional dosage had no effect on blood viscosity, plasma viscosity, red blood cell deformability.

Özet

Amaç: Jinekolojik kanser ameliyatlarında ameliyat sırası ve sonrasında analjezi sağlanmasında adjuvan ajan olarak kullanılan magnezyum sülfatın kan reolojisi üzerine etkilerinin araştırılmasıdır. Gereç ve Yöntem: Prospektif, rasgele, tek kör olarak planlanan çalışmaya jinekolojik kanser ameliyatı olacak 31 hasta dâhil edildi. Magnezyum sülfat (Mg) grubuna anestezi indüksi-yonundan 30 dk. önce 30 mg/kg % 15lik magnezyum sülfat 5 dk. içinde IV infüzyon olarak uygulandı. Kontrol grubuna benzer volümde ve hızda % 0.9 sodyum klorür verildi. Magnezyum uygulamasından önce, 90. dk. ve 24. saatte alınan kan örneklerinde kan vizkozitesi, plazma vizkozitesi, eritrosit deformabilitesi, Mg, Na, K, Ca, total protein, albümin, fibrinojen ve hematokrit ölçümleri yapıldı. Bulgular: Gruplar arası karşılaştırmada benzer ölçüm zamanlarında düşük, orta ve yüksek kayma hızındaki kan vizkozitesi değerleri ve % 45 hematokrit düzeyine standardize edilmiş kan vizkozitesi değerleri, eritrosit deformabilitesi değerleri, 90. dk. ve 24. saatteki plazma vizkozitesi değerleri arasında istatistiki olarak anlamlı fark saptanmadı (p

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Cite This Article

EROLÇAY, H., ALAY, F. Ü. (2022). Effect of magnesium sulphate infusion on blood rheology during gynecologic oncology surgery. Göztepe Tıp Dergisi, Cilt: 27 - Sayı: 4, 174–181. https://ajindex.com/articles/526107

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