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Journals / Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi / 2018 / Cilt: 24 - Sayı: 1

Administration of Paracetamol, Diclofenac Sodium, and Tramadol for Postoperative Analgesia After Coronary Artery Bypass Surgery

Koroner Arter Baypas Cerrahisinden Sonra Postoperatif Analjezide Parasetamol, Diklofenak Sodyum ve Tramadol Verilmesi

Zuhal Aykaç
Nihan Yapıcı
Türkan Kudsioğlu
Yaşar Arslan
Pages
23–28
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

There was no statistically significant difference between the three analgesia groups.Conclusion: Based on our study results, analgesic effect of IV paracetamol appears to be similar to diclofenac and tramadol.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study we aimed to compare the effects of paracetamol, diclofenac sodium, and tramadol administration on postoperative pain during postoperative period of the patients who underwent coronary artery bypass grafting (CABG).Material and Method: After acquirement of the approval of ethics committee and informed consent of the patients, 200 patients with normal renal and liver functions and an ejection fraction value of 40 % who would undergo CABG were included in the study.
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Key Findings & Data:The patients were randomly divided into four groups: Group I (n=50) paracetamol group (IV); Group II (n=50) diclofenac sodium (IM) group; Group III (n=50) tramadol (IV) group, and Group IV (n=50) placebo group.
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Conclusion & Impact:There was no statistically significant difference between the three analgesia groups.Conclusion: Based on our study results, analgesic effect of IV paracetamol appears to be similar to diclofenac and tramadol.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study we aimed to compare the effects of paracetamol, diclofenac sodium, and tramadol administration on postoperative pain during postoperative period of the patients who underwent coronary artery bypass grafting (CABG).Material and Method: After acquirement of the approval of ethics committee and informed consent of the patients, 200 patients with normal renal and liver functions and an ejection fraction value of 40 % who would undergo CABG were included in the study. The patients were randomly divided into four groups: Group I (n=50) paracetamol group (IV); Group II (n=50) diclofenac sodium (IM) group; Group III (n=50) tramadol (IV) group, and Group IV (n=50) placebo group. Group IV patients were given only 2 μg/kg/h of fentanyl. Hemodynamic values and biochemical parameters were recorded. Postoperative pain was assessed using Visual Analog Scale (VAS).Results: In the placebo group, PaCO2 levels were higher, mean arterial pressure was higher and extubation time was longer than the other groups. There was no statistically significant difference between the three analgesia groups.Conclusion: Based on our study results, analgesic effect of IV paracetamol appears to be similar to diclofenac and tramadol.

Özet

Amaç: Bu çalışmada, koroner arter baypas (KABG) ameliyatı geçiren hastalara postoperatif süreçte parasetamol, diklofenak sodyum ve tramadol uygulamasının postoperatif ağrı üzerine etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Etik komite ve bilgilendirilmiş onamları alınan KABG uygulanacak normal böbrek ve karaciğer fonksiyonlarına sahip ve ejeksiyon fraksiyonu %40 üzerinde olan 200 hasta çalışmaya alındı. Hastalar rastgele 4 gruba ayrıldı; grup I (n=50) parasetamol IV, grup II (n=50) diklofenak sodyum IM, group III (n=50) IV tramadol alan hastalar, ve grup IV (n=50) plasebo. Grup IV’teki hastalar yalnızca 2 μg/kg/saat fentanil aldı. Hemodinamik ve biyokimyasal parametreler kaydedildi. Postoperatif ağrı vizüel analog skala (VAS) ile değerlendirildi. Bulgular: Plasebo grubunda ekstübasyon zamanı daha uzun, PaCO2 seviyeleri ve ortalama kan basıncı diğer gruplara göre daha yüksekti. Diğer analjezi grupları arasında istatistiksel olarak anlamlı fark yoktu. Sonuç: Çalışmamızda, IV parasetamolün analjezik etkisinin diklofenak ve tramadole benzer olduğu görüldü.

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Cite This Article

Aykaç, Z., Yapıcı, N., Kudsioğlu, T., Arslan, Y. (2022). Administration of Paracetamol, Diclofenac Sodium, and Tramadol for Postoperative Analgesia After Coronary Artery Bypass Surgery. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi, Cilt: 24 - Sayı: 1, 23–28. https://ajindex.com/articles/526005

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