Journals / Glokom Katarakt / 2018 / Cilt: 13 - Sayı: 3

Toxic Anterior Segment Syndrome: Is it Possible to Have Corneal Dysfunction Without Changes in Corneal Morphology?

Toksik Anterior Segment Sendromu: Kornea Morfolojisi Bozulmadan Korneal Disfonksiyon Gelişir mi?

Pages
139–143
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim is to contribute to the identifi cation and proper management ofsimilar patients and to discuss whether TASS causes corneal dysfunction without changes in corneal morphology, as the early detectionof mild cases is important in preventing potentially severe cases.

📌 3 Key Takeaways

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Objective & Hypothesis:Toxic anterior segment syndrome (TASS) is a sterile postoperative infl ammatory reaction caused by a noninfectious substance thatenters the anterior segment, resulting in a wide range of toxic damage to intraocular tissues.
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Key Findings & Data:The process typically begins 12 to 48 hoursafter anterior-segment surgery, but delayed mild cases have been reported.
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Conclusion & Impact:The aim is to contribute to the identifi cation and proper management ofsimilar patients and to discuss whether TASS causes corneal dysfunction without changes in corneal morphology, as the early detectionof mild cases is important in preventing potentially severe cases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Toxic anterior segment syndrome (TASS) is a sterile postoperative infl ammatory reaction caused by a noninfectious substance thatenters the anterior segment, resulting in a wide range of toxic damage to intraocular tissues. The process typically begins 12 to 48 hoursafter anterior-segment surgery, but delayed mild cases have been reported. In this paper, a case of mild late-onset TASS that specifi callycaused corneal edema without changes in corneal morphology is described. While, ideally, corneal morphology should be documentedby a corneal confocal microscopy, this case could be documented by a biomicroscopic anterior and posterior segment examination,central corneal thickness (CCT) detection by a corneal B mode ultrasound and a corneal specular microscope without corneal confocalmicroscopy. For this case, mild corneal edema was observed on postoperative day 32 (the CCT was 701 μm on postoperative day 32,602 μm on postoperative day 75) without any specular microscopic changes (the preoperative endothelial cell density was 2660 cells/mm 2 , and on postoperative day 75, it was 2660 cells/mm 2 ) and major infl ammation in the anterior and posterior segment of the eye,which responded well and promptly to topical steroid treatment. The aim is to contribute to the identifi cation and proper management ofsimilar patients and to discuss whether TASS causes corneal dysfunction without changes in corneal morphology, as the early detectionof mild cases is important in preventing potentially severe cases.

Özet

Toksik anterior segment sendromu (TASS), enfeksiyöz olmayan toksik ajanların ön segmente girmesi sonucu oluşan, göz içi dokularda değişen yaygınlıkta ve şiddette hasara neden olan steril cerrahi sonrası infl amasyondur. Süreç, tipik olarak ön segment cerrahisinden 12-48 saat sonra başlasa da geç başlayan, hafi f belirti ve bulgularla seyreden olgular bildirilmiştir. Bu çalışmada, korneada morfolojik değişikliklere neden olmadan özellikle kornea ödemine yol açan hafi f ve geç başlangıçlı TASS olgusu sunulmuştur. Kornea konfokal mikroskopi, kornea morfolojisini en iyi değerlendiren yöntem olmasına rağmen bu olgu, biomikroskopik ön ve arka segment muaye- nesi, B mod ultrason ile merkezi kornea kalınlık (MKK) ölçümü ve kornea speküler mikroskopi yapılarak değerlendirilebilmiştir. Bu olguda, ameliyat sonrası 32. günde speküler mikroskopik değişiklikler (endotel hücre yoğunluğu; ameliyat öncesi: 2660 hücre/mm 2 , ameliyat sonrası 75. gün: 2660 hücre/mm 2 ) ve belirgin göz içi infl amasyon olmaksızın hafi f kornea ödemi (MKK; ameliyat sonrası 32. gün: 701 μm, ameliyat sonrası 75. gün: 602 μm) tespit edildi. Topikal steroid tedavisine hızlı ve iyi yanıt gözlendi. Hafi f TASS olgula- rının erken fark edilmesi, daha sonra karşılaşılabilecek ciddi vakaların önlenmesini sağlayabilir. Bu olgu sunumunda, benzer hastaların teşhisine ve doğru tedavisine katkıda bulunmak, TASS olgularında kornea morfolojisi değişmeden kornea fonksiyon bozukluğu oluşu- munu tartışmak amaçlanmıştır.

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Cite This Article

YASSA, E. T., BAKBAK, B. (2022). Toxic Anterior Segment Syndrome: Is it Possible to Have Corneal Dysfunction Without Changes in Corneal Morphology?. Glokom Katarakt, Cilt: 13 - Sayı: 3, 139–143. https://ajindex.com/articles/525779

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