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Journals / Glokom Katarakt / 2021 / Cilt: 16 - Sayı: 2

The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model

Çiğdem ELMAS
Zeynep AKTAŞ
Çağlar BEKTAŞ
Nilay DİLEKMEN
Cemile Merve SEYMEN
Hatice Tuba ATALAY
Pages
122–128
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The eyes in group 2, 3 and 4 showed signifi cantly less vascularization than the control group (p = 0.015, p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To investigate the wound healing effect of topical and subconjunctival Coenzyme Q10 (CoQ) in an experimental trabeculectomy model, and to compare the outcomes with mitomycin C and bevacizumab.
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Key Findings & Data:Materials and Methods: Thirty eyes of 27 Wistar Albino rats were included.
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Conclusion & Impact:The eyes in group 2, 3 and 4 showed signifi cantly less vascularization than the control group (p = 0.015, p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To investigate the wound healing effect of topical and subconjunctival Coenzyme Q10 (CoQ) in an experimental trabeculectomy model, and to compare the outcomes with mitomycin C and bevacizumab. Materials and Methods: Thirty eyes of 27 Wistar Albino rats were included. Group 1 was the control group and the other four groups were mitomycin C (group 2), topical CoQ (group 3), subconjunctival CoQ (group 4), and bevacizumab (group 5). Conjunctival and scleral incisions were made to mimic the trabeculectomy wound. After the rats were sacrifi ced, histological sections were examined for vasculogenesis, VEGF and TGF-β1 positivity. Results: The mean vascularization score was lowest in groups 3 and 4 (0.5±0.55). It was followed by group 2 (1.0± 0.89), group 5 (1.5±1.0), and control group (2.5±0.55). The eyes in group 2, 3 and 4 showed signifi cantly less vascularization than the control group (p = 0.015, p

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Cite This Article

ELMAS, Ç., AKTAŞ, Z., BEKTAŞ, Ç., DİLEKMEN, N., SEYMEN, C. M., ATALAY, H. T. (2022). The Effect of Topical and Subconjunctival Coenzyme Q10 on Wound Healing Modulation in an Experimental Trabeculectomy Model. Glokom Katarakt, Cilt: 16 - Sayı: 2, 122–128. https://ajindex.com/articles/525751

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