Journals / Genel Tıp Dergisi / 2021 / Cilt: 31 - Sayı: 4

The Effect of Non-pharmacological Combine Treatment Methods on Serum Beta-Endorphin Level, Pain, Depression, Sleep Quality and Functional Status in Patients with Fibromyalgia

Non-farmakolojik Kombine Tedavi Yöntemlerinin Fibromiyaljili Hastalarda Serum Beta-Endorfin Düzeyi, Ağrı, Depresyon, Uyku Kalitesi ve Fonksiyonel Durum Üzerine Etkisi

Pages
354–359
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The β-Endorfin level was lower in both FMS groups than the control group and this was statistically significant (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Abstract Objective: This study aims to compare the effectiveness of non-pharmacological combined treatment methods used in Fibromyalgia syndrome (FMS) treatment by evaluating serum β -Endorphine, pain, depression, sleep quality and functional status.
📊
Key Findings & Data:Methods: The study included 60 patients diagnosed with FMS and 30 healthy female volunteers.
💡
Conclusion & Impact:Results: The β-Endorfin level was lower in both FMS groups than the control group and this was statistically significant (p
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Fibromyalji · aerobik egzersiz · balneoterapi

Abstract

Abstract Objective: This study aims to compare the effectiveness of non-pharmacological combined treatment methods used in Fibromyalgia syndrome (FMS) treatment by evaluating serum β -Endorphine, pain, depression, sleep quality and functional status. Methods: The study included 60 patients diagnosed with FMS and 30 healthy female volunteers. The patients with FMS were divided into two equal groups of 30 subject. The first group of patients received physical therapy and balneotherapy, while the second group received physical therapy, balneotherapy and aerobic exercise program. FMS patients evaluated before and after treatment, by Visual Analogue Scale for Pain (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Scale (BDI) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. Serum β-Endorphin levels were measured once in the healthy control group and twice before and after treatment in FMS patients. Results: The β-Endorfin level was lower in both FMS groups than the control group and this was statistically significant (p

Özet

Amaç: Bu çalışmanın amacı FMS tedavisinde kullanılan non-farmakolojik kombine tedavi metodlarının etkinliğini serum β–Endorfin, ağrı, depresyon, uyku kalitesi ve fonksiyonel durumu değerlendirerek karşılaştırmaktır. Yöntemler: Çalışmaya FMS tanısı almış 60 kadın hasta ve 30 sağlıklı kadın gönüllü dahil edildi. FMS'li hastalar rastgele 30 kişiden oluşan iki eşit gruba ayrıldı. İlk hasta grubuna fizik tedavi ve balneoterapi uygulanırken, ikinci gruba fizik tedavi, balneoterapi ve aerobik egzersiz programı uygulandı. FMS hastaları tedavi öncesi ve sonrası, ağrı için Görsel Analog Skala (GAS), Fibromiyalji Etki Anketi (FEA), Beck Depresyon Ölçeği (BDÖ) ve Pittsburgh Uyku Kalitesi İndeksi (PUKİ) anketleriyle değerlendirildi. Serum β-Endorfin seviyeleri, sağlıklı kontrol grubunda bir kez, FMS hastalarında tedavi öncesi ve sonrası iki kez ölçüldü. Bulgular: FMS’li hasta gruplarında β-Endorfin düzeyi sağlıklı kontrol grubuna göre daha düşüktü ve bu istatistiksel olarak anlamlıydı (p

🔖

Cite This Article

DOĞAN, H. O., BOSTANCI, F., KARADAĞ, A. (2022). The Effect of Non-pharmacological Combine Treatment Methods on Serum Beta-Endorphin Level, Pain, Depression, Sleep Quality and Functional Status in Patients with Fibromyalgia. Genel Tıp Dergisi, Cilt: 31 - Sayı: 4, 354–359. https://ajindex.com/articles/524615

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Karadag A, Hayta E, Celik VK, Bakir S. Serum vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in patients with fibromyalgia syndrome. Arch Rheumatol 2019;34:414-18.
  2. Korucu RU, Karadağ A, Taş A et al. Serum Calcitonin Gene-Related Peptide and Receptor Protein Levels in Patients With Fibromyalgia Syndrome: A Cross-Sectional Study. Arch Rheumatol 2020;35:463-67.
  3. Kocak I, Hizmetli S, Tas A, Karadag A et al. High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome. Int J Rheum Dis 2020;23:966-69.
  4. Adler GK, Kinsley BT, Hurwitz S, Mossey CJ, Goldenberg DL. Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med 1999;106:534–43.
  5. Semiz EA, Hizmetli S, Semiz M et al. Serum cortisol and dehydroepiandrosterone-sulfate levels after balneotherapy and physical therapy in patients with fibromyalgia Saudi Med J 2016;375:544-50.
  6. Fichna J, Janecka A, Costentin J, Rego do J. The Endomorphin System and Its Evolving. Pharmacol reviwes 2007;591:88–3.
  7. Goldfarb AH, Jamurtas AZ. Beta-endorphin response to exercise. An Updat Sport Med 1997;24:8–16.
  8. Paulev PE, Thorbøll JE, Nielsen U et al. Opioid involvement in the perception of pain due to endurance exercise in trained man. Physiol. 1989;39:67–4
  9. Schmidt-Wilcke T, Clauw DJ. Fibromyalgia: From pathophysiology to therapy. Nat Rev Rheumatol 2011;7:518–7.
  10. Karadağ A, Canbaş M, Parlak M. Balneoterapinin fibromiyalji hastalarında ağrı ve yaşam kalitesine etkisi. Mustafa Kemal Üniversitesi Tıp Dergisi 2018;9:114-20.
  11. Grisel JE, Bartels JL, Allen SA, Turgeon VL. Influence of β-Endorphin on anxious behavior in mice: interaction with EtOH. Psychopharmacology 2008;200:105-5. Rod K. Dishman PJO. Lessons in exercise neurobiology: The case of endorphins. Ment Health Phys Act 2009;2:4–9.
  12. Bender T, Bariska J, Vághy R, et al. Effect of balneotherapy on the antioxidant system--a controlled pilot study. Arch Med Res 2007;38:86-9.
  13. Karadağ A, Doğan HO. Serum paraoxonase enzyme activity after balneotherapy in patients with fibromyalgia. Medical Science and Discovery 2020;7:429-2. Bellometti S GL. Function of the hypothalamic adrenal axis in patients with fibromyalgia syndrome undergoing mud-pack treatment. Int J Clin Pharmacol Res 1999;19:27–3.
  14. Fioravanti A, Cantarini L, Guidelli GM, Galeazzi M. Mechanisms of action of spa therapies in rheumatic diseases: what scientific evidence is there? Rheumatol Int 2011;31:1–8. Wolfe F,