The results show that allthe synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B.cereus, B. abortus and C. albicans when compared to standard drugs.
📌 3 Key Takeaways
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Objective & Hypothesis:A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolarcycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate.
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Key Findings & Data:The structures of thesynthesized compounds were characterized using spectroscopic methods.
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Conclusion & Impact:The results show that allthe synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B.cereus, B. abortus and C. albicans when compared to standard drugs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A series of novel substituted isoxazolidine derivatives were synthesized by 1,3-dipolarcycloaddition reactions of α-aryl-N-methyl nitrones with diethyl maleate. The structures of thesynthesized compounds were characterized using spectroscopic methods. All the synthesizedcompounds were screened for their antibacterial activities against Gram-positive and Gramnegativebacteria and for their antifungal activities against a yeast strain. The results show that allthe synthesized compounds displayed significant activity against S. epidermidis, M. luteus, B.cereus, B. abortus and C. albicans when compared to standard drugs.
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Cite This Article
YANMAZ, V., DİLEK, G., YAVUZ, S., DİŞLİ, A., ÖĞÜTÇÜ, H. (2022). Synthesis of Some Novel Isoxazolidine Derivatives via 1,3-Dipolar Cycloaddition and Their Biological Evaluation. Gazi University Journal of Science, Cilt: 32 - Sayı: 1, 78–89. https://ajindex.com/articles/521317
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